1.
Ren Fail
; 35(4): 547-50, 2013.
Article
in English
| MEDLINE
| ID: mdl-23472940
ABSTRACT
Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an effective and specific treatment in AA amyloidosis secondary to chronic inflammatory disorders. We report on a patient diagnosed with BD who developed nephrotic syndrome caused by renal AA amyloidosis with an excellent response to TCZ therapy.
Subject(s)
Amyloidosis/complications , Antibodies, Monoclonal, Humanized/therapeutic use , Behcet Syndrome/complications , Kidney/pathology , Nephrotic Syndrome/drug therapy , Amyloidosis/drug therapy , Behcet Syndrome/drug therapy , Female , Humans , Middle Aged , Nephrotic Syndrome/etiology , Treatment Outcome
2.
Nefrologia
; 30(3): 360-6, 2010.
Article
in Spanish
| MEDLINE
| ID: mdl-20514104
Subject(s)
Glomerulonephritis/pathology , Podocytes/pathology , Adult , Biomarkers/analysis , Cell Dedifferentiation , Disease Progression , Glomerulonephritis/complications , HIV Seronegativity , Humans , Intellectual Disability/complications , Intellectual Disability/genetics , Keratins/analysis , Ki-67 Antigen/analysis , Kidney Failure, Chronic/etiology , Kidney Failure, Chronic/therapy , Kidney Glomerulus/ultrastructure , Macrophages/ultrastructure , Male , Podocytes/chemistry , Renal Dialysis
3.
Nefrología (Madr.)
; 30(3): 360-366, mayo-jun. 2010. ilus, tab
Article
in Spanish
| IBECS
| ID: ibc-104565
ABSTRACT
No disponible
