Implantable Loop Recorders in Patients with Unexplained Syncope: Does Ethnic Background Influence Diagnostic Yield?

BACKGROUND: Implantable loop recorders (ILRs) are a central tool in the evaluation of unexplained syncope. These devices record and store electrocardiograms, both automatically and on patient-dependent activation. Therefore, obtaining optimal diagnostic results relies on a patient's comprehension and collaboration. OBJECTIVES: To evaluate the effect of ethnic background and mother-tongue language on the diagnostic yield (DY) of ILRs. METHODS: Patients at two medical centers in Israel, who had ILRs as part of syncope workup were included. Inclusion criteria were age over 18 years and an ILR for at least one year (or less if the cause of syncope was detected). Patient demographics, ethnic background, and previous medical history were recorded. All findings from ILR recordings, activation mode (manual vs. automatic), and treatment decisions (none, ablation, device implantation) were collected. RESULTS: The study comprised 94 patients, 62 Jews (i.e., ethnic majority) and 32 non-Jews (i.e., ethnic minority). While baseline demographic characteristics, medical history, and drug therapy were similar in both groups, Jewish patients were significantly older at the time of device implantation: 64.3 ± 16.0 years of age vs. 50.6 ± 16.9, respectively; (P < 0.001). Arrhythmias recorded in both groups as well as treatment decisions and device activation mode were similar. Total follow-up time from device implantation was longer in the non-Jewish vs. the Jewish group (17.5 ± 12.2 vs. 24.0 ± 12.4 months, respectively; P < 0.017). CONCLUSIONS: The DY of ILR implanted for unexplained syncope did not seem to be influenced by patient's mother-tongue language or ethnicity.

Routine fixed-dose heparin vs. ACT-guided heparin administration for elective PCI and its influence on patient in-hospital outcome: a retrospective study.

OBJECTIVE: Activated clotting time (ACT)-based heparin dosing during percutaneous intervention (PCI) is recommended by Society guidelines. However, the relationship between ACT and outcome in the setting of elective PCI has not been sufficiently studied. We sought to evaluate the in-hospital outcome of patients undergoing elective PCI while receiving fixed-dose heparin without ACT measurement versus those with ACT-guided management. METHODS: This retrospective study included consecutive patients undergoing elective PCI in a single-center between 11/2015 and 12/2018. Patients were divided into two groups, depending on whether ACT was measured. Heparin-only anticoagulation and non-femoral procedures were allowed. Patient demographics, procedural data and in-hospital outcomes were collected. The primary outcome was in-hospital major adverse cardiovascular events (MACE), secondary (safety) outcomes were in-hospital definite stent thrombosis, Bleeding Academic Research Consortium bleeding, access-related complications (any) as well as peri-procedural complications. RESULTS: In total, 500 procedures were included in the study, 151 ACT and 349 fixed-dose. Patient demographics and medical history in both groups were well balanced, but those having ACTs were younger (63.2 ± 10.9 vs. 66.5 ± 11.3; P = 0.003) and less likely to have a history of coronary artery disease (74 vs. 82%; P = 0.032) or kidney failure. Procedural data were similar; however, total heparin dose and procedure length were higher in the ACT group (6232 ± 1388 vs.5032 ± 417 units; P < 0.001; 40.1 ± 14.0 vs. 30.3 ± 12.7 min; P < 0.001). Primary and secondary outcome events were rare and similar (MACE 1.1 vs. 1.3%; P = 0.86). CONCLUSIONS: A fixed-dose heparin injection (5000 IU) approach for elective PCI while omitting ACT offers slightly shortened procedural time and similar in-hospital safety profile.

Is second hand smoking associated with atrial fibrillation risk among women in Israel? A case-control study.

BACKGROUND: The first complete ban on indoor smoking in all public spaces (including bars and restaurants) occurred in 1994 in Israel, because of clear scientific evidence that SHS (Second Hand Smoking) is dangerous to non-smokers. Despite the smoking-ban law warning about the dangers of smoking, SHS remains in houses. The role of cigarette smoking on cardiac arrhythmia is less clearly defined and secondhand smoke (SHS) impact on the risk of atrial fibrillation (AF) remains unknown. The aim of this study was to evaluate the relationship between SHS and AF risk in Israeli women. METHODS: This was a population-based case-control study consisting of never-smoking women aged 30-80 from Israel: 102 cases (diagnosed) of AF and 109 population- based controls. All participants were interviewed using a socio-demographic questionnaire that also related to past and current exposure to SHS. RESULTS: SHS was associated with AF risk with adjusted odds ratio (OR) of 3.81 (95% confidence interval, CI 2.02-7.18). Higher exposure to SHS was associated with higher risk of AF compared to never-exposed women. Those exposed to SHS during one, two, or three life-periods (childhood, adolescence or adulthood) had an OR of 1.71 (95% CI 0.76-3.86), 2.87 (95% CI 1.25-6.56), and 9.14 (95% CI 4.09-20.44), respectively. Moreover, exposure to one pack/day increased the risk of AF by 2.89 times compared to 'never exposed' (95% CI 2.05-4.09). CONCLUSIONS: SHS exposure in women who never smoked is associated with increased risk for AF.