1.
Mol Cell Biochem
; 395(1-2): 211-9, 2014 Oct.
Article
in English
| MEDLINE
| ID: mdl-24990246
ABSTRACT
Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with ß-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified ß-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of ß-catenin, and found that TRAF4 mediated the translocation of ß-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.