ABSTRACT
With the global spread of various human-to-human epidemics, public health issues have become a focus of attention. Therefore, it is of great importance to improve the quantitative risk assessment of the construction of resilient cities in terms of epidemic disasters. Starting with the dimensions of social activities and material space, this paper took Qingdao, China, with a population of 5 million, as an example, and took its seven municipal districts as the research scope. In this paper, five risk factors, including the Population density index, Night light index, Closeness index of roads, Betweenness index of roads and Functional mixed nuclear density index were selected for weighted superposition analysis. We conducted a quantitative assessment of the spatial risk of epidemic disaster so as to obtain the classification and spatial structure of the epidemic disaster risk intensity. The results show that: â The roads with a large traffic flow are most likely to lead to the risk of urban spatial agglomeration, and the areas with a large population density and large mixture of infrastructure functions are also important factors causing the risk of epidemic agglomeration. â¡ The analysis results regarding the population, commerce, public services, transportation, residence, industry, green space and other functional places can reflect the high-risk areas for epidemic diseases with different natures of transmission. ⢠The risk intensity of epidemic disasters is divided into five risk grade areas. Among them, the spatial structure of epidemic disasters, composed of the first-level risk areas, is characterized by "one main area, four secondary areas, one belt and multiple points" and has the characteristics of spatial diffusion. ⣠Catering, shopping, life services, hospitals, schools and transportation functional places are more likely to cause crowd gathering. The management of these places should be focused on prevention and control. At the same time, medical facilities should be established at fixed points in all high-risk areas to ensure the full coverage of services. In general, the quantitative assessment of the spatial risk of major epidemic disasters improves the disaster risk assessment system in the construction of resilient cities. It also focuses on risk assessment for public health events. It is helpful to accurately locate the agglomeration risk areas and epidemic transmission paths that are prone to outbreak or cause epidemic transmission in cities so as to assist the relevant practitioners in containing the epidemic from the initial stage of transmission in a timely manner and prevent the further spread of the epidemic.
Subject(s)
Disasters , Epidemics , Humans , Cities , China , HousingABSTRACT
PURPOSE: To evaluate the efficiency of radiomics signatures in predicting the response of transarterial chemoembolization (TACE) therapy based on preoperative contrast-enhanced computed tomography (CECT). MATERIALS: This study consisted of 111 patients with intermediate-stage hepatocellular carcinoma who underwent CECT at both the arterial phase (AP) and venous phase (VP) before and after TACE. According to mRECIST 1.1, patients were divided into an objective-response group (n = 38) and a non-response group (n = 73). Among them, 79 patients were assigned as the training dataset, and the remaining 32 cases were assigned as the test dataset. METHODS: Radiomics features were extracted from CECT images. Two feature ranking methods and three classifiers were used to find the best single-phase radiomics signatures for both AP and VP on the training set. Meanwhile, multi-phase radiomics signatures were built upon integration of images from two CECT phases by decision-level fusion and feature-level fusion. Finally, multivariable logistic regression was used to develop a nomogram by combining radiomics signatures and clinic-radiologic characteristics. The prediction performance was evaluated by AUC on the test dataset. RESULTS: The multi-phase radiomics signature (AUC = 0.883) performed better in predicting TACE therapy response compared to the best single-phase radiomics signature (AUC = 0.861). The nomogram (AUC = 0.913) showed better performance than any radiomics signatures. CONCLUSION: The radiomics signatures and nomogram were developed and validated for predicting responses to TACE therapy, and the radiomics model may play a positive role in identifying patients who may benefit from TACE therapy in clinical practice.
