ABSTRACT
The aim of this study was to explore the uric acid-lowering effect and renal protective effect of Eucommia ulmoides leaf extract (EULE). The results of xanthine oxidase inhibition assay showed EULE exhibited a high inhibition rate similar to that of allopurinol, with an IC50 value of 1.53 mg/mL. A chronic kidney disease (CKD) model was established in adenine-induced rats to investigate the therapeutic effect of EULE on CKD. The results demonstrated EULE could reduce blood pressure and improve renal index. Additionally, EULE could regulate serum and urine indicators of renal function injury, and restore renal tissue morphology. Mechanistically, EULE was found to downregulate levels of malondialdehyde (MDA), tumour necrosis factor-α (TNF-α), and interleukin-1ß (IL-1ß), while upregulating total antioxidant capacity (T-AOC), thereby alleviating inflammatory response in rats, leading to a reduction in renal damage. the Our findings provide potential applications of EULE as a natural product for the improvement of renal injury.
ABSTRACT
This paper proposes a novel all-optical fiber mode converter for mode conversion from LP01 to LP02 and vice versa. The mode converter is formed by connecting a single-mode fiber, a taper-core multi-mode fiber, and a few-mode fiber (FMF) together. The taper fiber core is designed to convert LP01 mode to LP02. The few-mode fiber is used to cut off the modes that are higher than LP02. It is shown that the proposed mode converter provides 20 dB extinction ratio and low insertion loss in a very broad optical bandwidth of 200 nm, from 1465 to 1665 nm. By further optimizing the FMF radius only for each of the O-, E-, S-, C-, U-, etc. bands, the mode converter can apply to any band of interest with higher performance. It is found that the performance of the mode converter has a large tolerance to structural parameters. The mode converter has the same performance in reciprocal operation, i.e., LP02 to LP01.