1.
Bioorg Med Chem Lett
; 9(7): 967-72, 1999 Apr 05.
Article
in English
| MEDLINE
| ID: mdl-10230622
ABSTRACT
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.