ABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Fluorodeoxyglucose F18 , Brain Neoplasms , Vascular System Injuries/complications , Vascular System Injuries , Choline Dehydrogenase , Positron-Emission Tomography/instrumentation , Positron-Emission Tomography/methods , Positron-Emission TomographySubject(s)
Brain Injuries/diagnostic imaging , Brain Neoplasms/diagnosis , Cerebral Hemorrhage/diagnostic imaging , Foreign Bodies/diagnostic imaging , Magnetic Resonance Imaging/methods , Multimodal Imaging/methods , Neuroimaging/methods , Positron Emission Tomography Computed Tomography/methods , Temporal Lobe/diagnostic imaging , Aged , Blood Vessels/injuries , Blood-Brain Barrier , Brain Injuries/complications , Brain Injuries/surgery , Cerebral Hemorrhage/etiology , Choline , Diagnosis, Differential , Fluorine Radioisotopes , Foreign Bodies/complications , Foreign Bodies/surgery , Headache/etiology , Humans , Male , Metals , RadiopharmaceuticalsABSTRACT
Surgical excision of a venous malformation on a young girl's thigh left a large and deep ulcerative wound. Treatment of the lesion with Promogran dressings suited this patient's specific needs and produced substantial healing within five weeks.
Subject(s)
Bandages , Cellulose, Oxidized/therapeutic use , Collagen/therapeutic use , Postoperative Complications/therapy , Varicose Ulcer/therapy , Veins/abnormalities , Cardiovascular Abnormalities/surgery , Child , Female , Humans , Matrix Metalloproteinase Inhibitors , Wound HealingABSTRACT
Intragastric prosthesis (Lap-Band, BioEnterics Co., Carpinteria, CA, U.S.A.) migration is one of the major long-term complications of laparoscopic adjustable silicone gastric banding. The causes, clinical signs, timing, and overall incidence of band entrapment have not been prospectively investigated in a large series. The purpose of this study was to assess prospectively the incidence of Lap-Band intragastric migration and to establish the safety and effectiveness of minimally invasive band removal. Between January 1996 and June 2000, 148 consecutive patients enrolled in a multidisciplinary bariatric program underwent laparoscopic adjustable silicone gastric banding. In the follow-up treatment, gastrointestinal endoscopy was performed routinely. One hundred twenty-three patients with a minimum follow-up period of 12 months were entered into the study group. Eleven (9.2%) patients had long-term major complications. Intragastric band migration was observed in nine (7.5%) patients. The diagnosis was established by routine endoscopy between 10 and 41 months after surgery. Five erosions occurred in the first 30 cases (learning curve period). In six patients, the band was removed by an intragastric endoscopic-assisted approach avoiding laparotomy. The remaining three patients are under endoscopic surveillance. The results of this study show that routine upper gastrointestinal endoscopy can discover asymptomatic band migrations early. Band erosion did not require emergency treatment and can be removed safely by a minimally invasive approach.
Subject(s)
Foreign-Body Migration/surgery , Gastroplasty/instrumentation , Laparoscopy/methods , Adult , Device Removal , Female , Foreign-Body Migration/diagnosis , Gastroplasty/adverse effects , Gastroscopy , Humans , Male , Middle Aged , Prospective Studies , Reoperation , SiliconesABSTRACT
We have used chemo-immunotherapy with 5-fluorouracil (5-FU), thymosin alpha1 (T alpha1) and interleukin-2 (IL-2) to treat multiple liver metastases from colorectal cancer induced by DHD/K12 cells in syngeneic BDIX rats, comparing one and two cycles of treatment, and different treatment combinations. 5-FU was delivered loco-regionally as a continuous infusion via an intraperitoneal (i.p.) catheter from a subcutaneously implanted mini-pump, a method we developed for this study. We show here that two cycles of a triple chemo-immunotherapy regimen significantly increased the average survival time compared to one cycle, and compared to untreated controls or those treated with two cycles of 5-FU alone. At 150 days, two rats treated with two cycles of triple therapy were cured, showing no signs of cancer at autopsy; all the other rats died before this time. Triple chemo-immunotherapy resulted in significantly fewer extra-hepatic metastases than in the controls and in those treated with 5-FU only. Further, we found that two cycles of triple treatment significantly increased the absolute number of peripheral T cells expressing IL-2 receptor, CD4 and CD8 compared to controls. We conclude that two cycles of chemo-immunotherapy with 5-FU, T alpha1 and IL-2 were superior to one cycle of treatment and to other treatments tested. Our results suggest that the triple therapy acts by increasing numbers of effector T cells. This method shows promise for the use of multi-cycle chemo-immunotherapy in the treatment of unresectable metastases of colorectal cancer in humans.