ABSTRACT
"Click reactions" are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and azides to the indirect radiofluorination of an estradiol derivative with potential applications in estrogen receptor imaging. The procedure was fully developed on an automated synthesis platform, and conditions were optimized to achieve the desired product with a reasonable yield without precipitation. Although the biological results were not adequate for a potential radiopharmaceutical, the outcome of this work is valuable since the use of automated platforms is required for the reliable and reproducible preparation of PET radiopharmaceuticals in GMP conditions while limiting the radiation dose rates to the personnel.
ABSTRACT
Objetivo: caracterizar el consumo de sustancias psicoactivas en adolescentes judicializados bajo el Sistema de Responsabilidad Penal entre 2009 y 2010 pertenecientes a una fundación de rehabilitación de Calarcá, Quindío. Métodos: se sistematizaron las historias psicosociales de los 66 adolescentes institucionalizados y posteriormente se llevó a cabo un análisis descriptivo de las variables. Resultados: se encontró mayor prevalencia del género masculino con un 97%, la edad promedio de inicio de consumo de SPA fue 12,8 años, el 30% ingresaron por fabricación, tráfico o porte de estupefacientes, el 21% pertenece a una familia extensa, el 18% iniciaron el consumo con marihuana. Conclusiones: teniendo en cuenta que se ha encontrado que el consumo de SPA y las conductas delictivas suelen darse a edades muy tempranas y la importancia de algunas dinámicas familiares que actúan como factor de riesgo. Se evidencia la necesidad de crear programas de apoyo en el que tanto adolescentes como familias se vean involucrados.
Objective: to characterize the consumption of psychoactive substances in adolescents prosecuted under the Criminal Responsibility System between 2009 and 2010 belonging to a rehabilitation foundation in Calarcá, Quindío. Methods: the psychosocial histories of the 66 institutionalized adolescents were systematized and a descriptive analysis of the variables was subsequently carried out. Results: a higher prevalence of the male gender was found with 97%, the average age of initiation of SPA consumption was 12.8 years, 30% were admitted due to manufacture, trafficking or carrying narcotic drugs, 21% belonged to an extended family , 18% started using marijuana. Conclusions: taking into account that it has been found that the consumption of SPA and criminal behaviors usually occur at very young ages and the importance of some family dynamics that act as a risk factor. The need to create support programs in which both adolescents and families are involved is evident.