ABSTRACT
OBJECTIVES: Inflammation has been proposed to be one of the main causes of musculoskeletal pain. Diet is a lifestyle factor that plays an important role in managing inflammation; thus, we assessed the inflammatory potential of diets using the empirical dietary inflammatory index (EDII) to investigate the relationship between diet and musculoskeletal pain. METHODS: This cross-sectional study included 212 elderly individuals who were selected from health centers in Tehran, Iran. Dietary intake was evaluated using a valid and reliable 147-item food frequency questionnaire. To measure the intensity of pain, a visual analogue scale was used. Multiple linear regression was applied to assess the association between the EDII and musculoskeletal pain. RESULTS: In total, 62.7% and 37.3% of participants had mild and severe pain, respectively. The EDII values were 0.97±0.72 and 1.10±0.66, respectively, in those with mild and severe pain. A higher EDII score was associated with more intense musculoskeletal pain after adjusting for age and sex (ß=0.20; 95% confidence interval [CI], 0.06-0.26; p<0.001), but not after adjustment for other confounders (ß=-0.13; 95% CI, -1.54 to 0.60; p=0.39). CONCLUSIONS: Our findings indicated that higher dietary inflammation might not be associated with musculoskeletal pain in older adults. However, further investigations are required to confirm these findings.
ABSTRACT
Biloma refers to the encapsulated accumulation of bile in the abdomen. Bilomas generally occur after bile duct disruption. The clinical case of the present report was a 75 Y/O woman with jaundice, fever, abdominal pain, lethargy, and anorexia who had been admitted to the emergency department. Endoscopic retrograde cholangiopancreatography (ERCP) showed severe diffuse dilation of the common bile duct (CBD) and common hepatic duct (CHD) with filling defects. One stone and some sludge and pus were extracted after balloon swiping. Plastic CBD stent placement was performed. An abdominal ultrasound scan showed a stone in the CBD and fluid collection in the right perirenal space. Under ultrasound guidance, a drainage tube was inserted into the retroperitoneal biloma. A serial ultrasound scan revealed a gradual decrease in the size of the biloma. Perforation of the bile duct, which is characterised by the collection of retroperitoneal fluid, is considered an extremely rare condition that can be fatal. Ultrasonography, computed tomography, and endoscopic retrograde cholangiopancreatography were used for the diagnosis. The treatment includes prevention of leakage and bile drainage.
ABSTRACT
BACKGROUND: Diabetes-induced chronic hyperglycemia results in the formation and aggregation of advanced glycation end-products (AGEs), which are products of non-enzymatic glycosylation of lipids or proteins. The development of diabetic complications can be accelerated by AGEs. In the current study, we aimed to explore the relationship between AGEs levels and ABC goals of diabetes control (A: Hemoglobin A1C < 7.0%, B: Blood pressure < 140/90 mmHg, and C: low-density lipoprotein cholesterol [LDL] < 100 mg/dL). METHODS: In the current cross-sectional study, 293 patients with type 2 diabetes mellitus (T2D), were enrolled. Demographic and clinical characteristics of the individuals were collected. AGEs levels were measured using quantitative fluorescence spectroscopy. Finally, the association of AGEs levels with patients' characteristics and ABC goals was assessed. RESULTS: Higher serum AGEs concentration was detected in older age, smoking patients and those with higher diastolic blood pressure, lower high-density lipoprotein (HDL) level, lower body mass index (BMI) and retinopathy. Moreover, the T2D patients who achieved higher numbers of ABC goals of diabetes were younger age (P-value = 0.003), with lower hemoglobin A1C (P-value = 0.001), fasting blood sugar (P-value = 0.002) diastolic blood pressure (P-value = 0.001), systolic blood pressure (P-value = 0.001), cholesterol (P-value = 0.001), LDL (P-value = 0.001), and AGEs (P-value = 0.023) levels. Diabetic patients with AGEs levels above 73.9% were about 2.2 times more likely to achieve none of ABC treatment goals (95% CI 1.107-3.616). CONCLUSION: Our results revealed the relationship between AGEs and ABC goal achievement, and microvascular diabetic complications, and imply that AGEs measurement may be valuable in the monitoring of diabetic patients' complications and treatment adjustment.