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1.
J Med Imaging Radiat Oncol ; 62(5): 642-648, 2018 Oct.
Article in English | MEDLINE | ID: mdl-29877611

ABSTRACT

INTRODUCTION: Highly specific preoperative localizing test is required to select patients for minimally invasive parathyroidectomy (MIP) in lieu of traditional four-gland exploration. We hypothesized that Tc-99m sestamibi scan interpretation incorporating numerical measurements on the degree of asymmetrical activity from bilateral thyroid beds can be useful in localizing single adenoma for MIP. METHODS: We devised a quantitative interpretation method for Tc-99m sestamibi scan based on the numerically graded asymmetrical activity on early phase. The numerical ratio value of each scan was obtained by dividing the number of counts from symmetrically drawn regions of interest (ROI) over bilateral thyroid beds. The final pathology and clinical outcome of 109 patients were used to perform receiver operating curve (ROC) analysis. RESULTS: Receiver operating curve analysis revealed the area under the curve (AUC) was calculated to be 0.71 (P = 0.0032), validating this method as a diagnostic tool. The optimal cut-off point for the ratio value with maximal combined sensitivity and specificity was found with corresponding sensitivity of 67.9% (56.5-77.2%, 95% CI) and specificity of 75.0% (52.8-91.8%, 95% CI). An additional higher cut-off with higher specificity with minimal possible sacrifice on sensitivity was also selected, yielding sensitivity of 28.6% (18.8-38.6%, 95% CI) and specificity of 90.0% (69.6-98.8%, 95% CI). CONCLUSIONS: Our results demonstrated that the more asymmetrical activity on the initial phase, the more successful it is to localize a single parathyroid adenoma on sestamibi scans. Using early-phase Tc-99m sestamibi scan only, we were able to select patients for minimally invasive parathyroidectomy with 90% specificity.


Subject(s)
Adenoma/diagnostic imaging , Hyperparathyroidism, Primary/diagnostic imaging , Parathyroid Neoplasms/diagnostic imaging , Patient Selection , Preoperative Care , Radiographic Image Interpretation, Computer-Assisted/methods , Radionuclide Imaging/methods , Adenoma/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Hyperparathyroidism, Primary/surgery , Male , Middle Aged , Parathyroid Neoplasms/surgery , Parathyroidectomy , Radiopharmaceuticals , Sensitivity and Specificity , Technetium Tc 99m Sestamibi
2.
Psychiatr Serv ; 68(12): 1213-1215, 2017 Dec 01.
Article in English | MEDLINE | ID: mdl-29191144

ABSTRACT

This column describes the development, implementation, and outcomes of a quality improvement learning collaborative that aimed to better integrate chaplaincy with mental health care services at 14 participating health care facilities evenly distributed across the U.S. Department of Veterans Affairs and Department of Defense. Teams of health care chaplains and mental health professionals from participating sites sought to improve cross-disciplinary service integration in six key domains: screening, referrals, assessment, communication and documentation, cross-disciplinary training, and role clarification. Chaplains and mental health providers across all facilities at participating sites were significantly more likely post-collaboration to report having a clear understanding of how to collaborate and to report using a routine process for screening patients who could benefit from seeing a professional from the other discipline. Foundational efforts to enhance cross-disciplinary awareness and screening practices between chaplains and mental health professionals appear particularly promising.


Subject(s)
Clergy , Intersectoral Collaboration , Mental Disorders/therapy , Mental Health Services/organization & administration , Pastoral Care/organization & administration , Quality Improvement , United States Department of Veterans Affairs/organization & administration , Humans , United States
3.
Skeletal Radiol ; 46(11): 1487-1498, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28717928

ABSTRACT

OBJECTIVE: Accurate assessment of knee articular cartilage is clinically important. Although 3.0 Tesla (T) MRI is reported to offer improved diagnostic performance, literature regarding the clinical impact of MRI field strength is lacking. The purpose of this study is to compare the diagnostic performance of clinical MRI reports for assessment of cartilage at 1.5 and 3.0 T in comparison to arthroscopy. MATERIALS AND METHODS: This IRB-approved retrospective study consisted of 300 consecutive knees in 297 patients who had routine clinical MRI and arthroscopy. Descriptions of cartilage from MRI reports of 165 knees at 1.5 T and 135 at 3.0 T were compared with arthroscopy. The sensitivity, specificity, percent of articular surfaces graded concordantly, and percent of articular surfaces graded within one grade of the arthroscopic grading were calculated for each articular surface at 1.5 and 3.0 T. Agreement between MRI and arthroscopy was calculated with the weighted-kappa statistic. Significance testing was performed utilizing the z-test after bootstrapping to obtain the standard error. RESULTS AND CONCLUSIONS: The sensitivity, specificity, percent of articular surfaces graded concordantly, and percent of articular surfaces graded within one grade were 61.4%, 82.7%, 62.2%, and 77.5% at 1.5 T and 61.8%, 80.6%, 59.5%, and 75.6% at 3.0 T, respectively. The weighted kappa statistic was 0.56 at 1.5 T and 0.55 at 3.0 T. There was no statistically significant difference in any of these parameters between 1.5 and 3.0 T. Factors potentially contributing to the lack of diagnostic advantage of 3.0 T MRI are discussed.


Subject(s)
Cartilage Diseases/diagnostic imaging , Cartilage, Articular/diagnostic imaging , Knee Joint/diagnostic imaging , Magnetic Resonance Imaging/methods , Adolescent , Adult , Aged , Aged, 80 and over , Arthroscopy , Female , Humans , Male , Middle Aged , Retrospective Studies , Sensitivity and Specificity
4.
Suicide Life Threat Behav ; 46(2): 206-12, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26255592

ABSTRACT

Chaplains play an important role in supporting the mental health of current and former military personnel; in this study, the engagement of Department of Veterans Affairs (VA), Army, Navy, and Air Force chaplains with suicidality among their service users were examined. An online survey was used to collect data from 440 VA and 1,723 Department of Defense (DoD) chaplains as part of the VA/DoD Integrated Mental Health Strategy. Differences were noted for demographics, work setting characteristics, encountering suicidality, and self-perceived preparation for dealing with suicidality. Compared to DoD chaplains, VA chaplains encounter more at-risk service users, yet feel less prepared for dealing with suicidality.


Subject(s)
Clergy , Mental Health Services , Military Personnel/psychology , Pastoral Care , Suicide Prevention , Suicide/psychology , Adult , Aged , Female , Humans , Interdisciplinary Communication , Intersectoral Collaboration , Male , Middle Aged , Professional Competence , United States , United States Department of Defense , United States Department of Veterans Affairs
5.
J Gen Intern Med ; 29 Suppl 4: 885-94, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25355089

ABSTRACT

BACKGROUND: Recognizing that clergy and spiritual care providers are a key part of mental health care systems, the Department of Veterans Affairs (VA) and Department of Defense (DoD) jointly examined chaplains' current and potential roles in caring for veterans and service members with mental health needs. OBJECTIVE: Our aim was to evaluate the intersection of chaplain and mental health care practices in VA and DoD in order to determine if improvement is needed, and if so, to develop actionable recommendations as indicated by evaluation findings. DESIGN: A 38-member multidisciplinary task group partnered with researchers in designing, implementing, and interpreting a mixed methods study that included: 1) a quantitative survey of VA and DoD chaplains; and 2) qualitative interviews with mental health providers and chaplains. PARTICIPANTS: Quantitative: the survey included all full-time VA chaplains and all active duty military chaplains (n = 2,163 completed of 3,464 invited; 62 % response rate). Qualitative: a total of 291 interviews were conducted with mental health providers and chaplains during site visits to 33 VA and DoD facilities. MAIN MEASURES: Quantitative: the online survey assessed intersections between chaplaincy and mental health care and took an average of 37 min to complete. Qualitative: the interviews assessed current integration of mental health and chaplain services and took an average of 1 h to complete. KEY RESULTS: When included on interdisciplinary mental health care teams, chaplains feel understood and valued (82.8-100 % of chaplains indicated this, depending on the team). However, findings from the survey and site visits suggest that integration of services is often lacking and can be improved. CONCLUSIONS: Closely coordinating with a multidisciplinary task group in conducting a mixed method evaluation of chaplain-mental health integration in VA and DoD helped to ensure that researchers assessed relevant domains and that findings could be rapidly translated into actionable recommendations.


Subject(s)
Mental Health Services/organization & administration , Pastoral Care/organization & administration , Clergy/psychology , Cooperative Behavior , Humans , United States , United States Department of Veterans Affairs , Veterans/psychology
6.
J Health Care Chaplain ; 20(4): 144-60, 2014.
Article in English | MEDLINE | ID: mdl-25255147

ABSTRACT

Leaders in health care chaplaincy and practice guidelines, such as the Association of Professional Chaplains' Standards of Practice, call for chaplains to develop an evidence-based approach to their work. The extent to which practicing chaplains accept this new paradigm is unclear. The aim of this study was to gather information regarding chaplains' attitudes and practices with respect to evidence-based chaplaincy care. Data for the study came from surveys of healthcare chaplains working in the Department of Veterans Affairs (VA, n = 440), the Department of Defense (DoD, n = 164), and civilian settings (n = 169). Chaplains from all three contexts strongly endorsed an evidence-based approach to chaplaincy. Approximately three-fourths of the healthcare chaplains from VA and DoD and 42% of those from civilian settings considered their current chaplaincy practices to be evidenced based, with over half in VA and DoD samples and 94% in the civilian sample indicating that they would like their chaplaincy care to be more evidence-based. Approximately half of the VA and DoD chaplains and 35% of the civilian chaplains reported currently using measurement tools in their chaplaincy care. These results suggest that there is generally strong support among practicing chaplains for an evidence-based approach to chaplaincy care.


Subject(s)
Attitude of Health Personnel , Chaplaincy Service, Hospital , Clergy/psychology , Evidence-Based Practice , Practice Patterns, Physicians'/statistics & numerical data , Clergy/statistics & numerical data , Health Care Surveys , Humans
7.
J Health Care Chaplain ; 19(1): 3-21, 2013.
Article in English | MEDLINE | ID: mdl-23551047

ABSTRACT

Chaplains play important roles in caring for Veterans and Service members with mental health problems. As part of the Department of Veterans Affairs (VA) and Department of Defense (DoD) Integrated Mental Health Strategy, we used a sequential approach to examining intersections between chaplaincy and mental health by gathering and building upon: 1) input from key subject matter experts; 2) quantitative data from the VA / DoD Chaplain Survey (N = 2,163; response rate of 75% in VA and 60% in DoD); and 3) qualitative data from site visits to 33 VA and DoD facilities. Findings indicate that chaplains are extensively involved in caring for individuals with mental health problems, yet integration between mental health and chaplaincy is frequently limited due to difficulties between the disciplines in establishing familiarity and trust. We present recommendations for improving integration of services, and we suggest key domains for future research.


Subject(s)
Mental Health Services/organization & administration , Pastoral Care/organization & administration , United States Department of Defense , United States Department of Veterans Affairs , Female , Health Services Accessibility , Humans , Male , Middle Aged , Qualitative Research , United States , Veterans/psychology
8.
J Diabetes Metab ; 42013 Dec 15.
Article in English | MEDLINE | ID: mdl-25258699

ABSTRACT

AIM: Self-management of diabetes improves glycemic control. The development of a quick, objective questionnaire in the clinic setting may provide data to the clinician caring for the patient in overall evaluation. OBJECTIVE: We developed a 23 question tool (clinic preparedness score) and administered it to type 1 and 2 (T1DM & T2DM) diabetes patients. Clinicians of patients were surveyed to determine their perception of adherence by patients. A total of 350 T1DM patients and families and 137 T2DM families were administered the questionnaire. Additionally, HbA1C was correlated to the various parameters that are related to improved glycemic control such as having a meter, carrying glucose tablets for hypoglycemia, and downloading/ writing blood sugars in log book in T1DM and T2DM. RESULTS: T1DM subjects had a lower HbA1C with better clinic preparedness (8.2 ± 1.3 vs. 9.4 ± 1.9%) However, this did not hold true for T2DM (p NS). If T1DM subjects adjusted their insulin dose and reported that their parent was involved they had better HbA1C than those that did not change insulin dose and if parent was uninvolved in the care. Clinicians of patients were able to accurately predict that appropriate dose adjustments resulted in good glycemic control. CONCLUSIONS: Pediatric T2DM adherence measures do not mirror similar characteristics of T1DM in childhood. The variability in glucose monitoring, medication and insulin administration may affect T2DM differently than T1DM.

9.
Fish Physiol Biochem ; 37(1): 105-12, 2011 Mar.
Article in English | MEDLINE | ID: mdl-20694746

ABSTRACT

We have assessed the fatty acid profiles of the hearts and different muscle tissues from nine large shark species (Carcharhinus limbatus (blacktip), Carcharhinus obscurus (dusky), Carcharhinus brevipinna (spinner), Carcharhinus leucas (Zambezi/bull), Galeocerdo cuvier (tiger), Sphyrna lewini (scalloped hammerhead), Sphyrna zygaena (smooth hammerhead), Carcharodon carcharias (great white) and Carcharias taurus (raggedtooth/grey nurse/sand tiger)) found off the east coast of South Africa. While there was generally little variation between the species, all species showed profiles rich in both n6 and n3 polyunsaturated fatty acids compared to terrestrial commercial meats that have low n3. Thus, utilizing skeletal muscle tissues from sharks caught as part of the bycatch when fishing for teleosts would avoid unnecessary wastage of a potentially valuable resource, with all the possible health benefits of high quality protein combined with balanced polyunsaturates, although contamination with high levels of metabolic wastes, such as urea, may be a negative consideration.


Subject(s)
Fatty Acids/analysis , Lipids/analysis , Muscles/chemistry , Myocardium/chemistry , Sharks/physiology , Animals , Indian Ocean , Meat/analysis , South Africa
10.
Ann Vasc Surg ; 23(5): 560-8, 2009.
Article in English | MEDLINE | ID: mdl-19128934

ABSTRACT

While aggressive endoluminal therapy for superficial femoral artery (SFA) occlusive disease is commonplace, the implications of chronic kidney disease (CKD) on long-term outcomes in this population are unclear. We examined the consequences of endovascular treatment of the SFA in patients with and without varying stages of CKD. A database of patients undergoing endovascular treatment of the SFA between 1986 and 2007 was queried, and two groups were defined: estimated glomerular filtration rate (eGFR) 60 mL/min/1.73 cm(2). Intention-to-treat analysis was performed. Results were standardized to TransAtlantic Inter-Society Consensus (TASC-II) and Society for Vascular Surgery criteria. Kaplan-Meier analyses were performed to assess time-dependent outcomes. Factor analyses were performed using a Cox proportional hazard model for time-dependent variables. Data are presented as mean +/- standard deviation where appropriate. There were 525 limbs in 535 patients (68% male, average age 66 +/- 14 years) that underwent endovascular treatment for claudication or chronic critical limb ischemia (51%). Patients with eGFR 60. In patients with critical limb ischemia, there was no difference in patency between those with eGFR 60. Limb salvage was worse in patients with eGFR 60. With respect to limb salvage, six factors were significantly associated with a reduction in rates: presence of tissue loss at presentation (relative risk [RR] = 6.45, p = 0.003), 0 or 1 vessel tibial runoff (RR = 2.56, p < 0.01), progression of distal disease noted in follow-up (RR = 4.62, p < 0.01), embolization at the initial intervention (RR = 2.70, p < 0.05), diabetes mellitus (RR = 3.71, p < 0.01), and a history of congestive heart disease (RR = 2.42, p < 0.01). Notable factors that were not significantly associated included lesion calcification (p = 0.64), TASC C or D lesion categorization (p = 0.99), acute occlusion at initial intervention (p = 0.40), and adjuvant stenting (p = 0.67). CKD does not impact the patency of SFA interventions. Limb salvage in patients with critical ischemia is significantly worse when the eGFR is

Subject(s)
Angioplasty, Balloon , Arterial Occlusive Diseases/therapy , Femoral Artery , Ischemia/therapy , Kidney Diseases/complications , Aged , Aged, 80 and over , Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/instrumentation , Angioplasty, Balloon/mortality , Arterial Occlusive Diseases/complications , Arterial Occlusive Diseases/mortality , Arterial Occlusive Diseases/physiopathology , Chronic Disease , Female , Femoral Artery/physiopathology , Glomerular Filtration Rate , Humans , Ischemia/etiology , Ischemia/mortality , Ischemia/physiopathology , Kaplan-Meier Estimate , Kidney Diseases/mortality , Kidney Diseases/physiopathology , Limb Salvage , Male , Middle Aged , Proportional Hazards Models , Retrospective Studies , Risk Assessment , Risk Factors , Severity of Illness Index , Stents , Time Factors , Treatment Outcome , Vascular Patency
11.
Ann Vasc Surg ; 22(3): 388-94, 2008.
Article in English | MEDLINE | ID: mdl-18411028

ABSTRACT

While aggressive endoluminal therapy for occlusive disease of the major branches of the arch of the aorta (brachiocephalic [BCA], left common carotid [LCCA], and left subclavian [LSCA] arteries) is commonplace, long-term outcomes in this population are unclear. We examined the long-term outcomes of endoluminal therapy for ostial aortic arch disease at a single tertiary referral academic medical center. A prospective database of patients undergoing endovascular treatment of aortic arch vessel atherosclerotic occlusive disease between 1990 and 2004 was maintained and retrospectively analyzed. Patients with stenotic ostial lesions of the major thoracic aorta branches were selected. Angiograms were reviewed in all cases to assess lesion characteristics. Patency was assessed by routine clinical and, in the LCCA and LSCA, duplex ultrasound follow-up at 1, 6, and 12 months postintervention and every 12 months thereafter. Results were standardized to current Trans-Atlantic Inter-Society Consensus and Society for Vascular Surgery criteria. Kaplan-Meier analyses were performed to assess time-dependent outcomes. Factor analyses were performed using a Cox proportional hazard model for time-dependent variables. Data are presented as mean +/- SEM. Forty-four patients (average age 64 +/- 2 years, 59% male) underwent 26 LSCA, 11 LCCA, and eight BCA interventions for primary indications of arm ischemia (29%), prevention or treatment of coronary steal syndrome (29%), or cerebrovascular signs/symptoms (42%). The technical success rate was 98%, with a 90-day mortality rate of 0% and a major adverse event rate of 2%. There were no strokes and no upper extremity embolic events. Cumulative patency was 88 +/- 8% at 3 years, with a reintervention rate of 7%. The overall symptom recurrence rate was 4%. No local or systemic factors were associated with poor outcomes. Endoluminal stenting for ostial disease of the branches of the aortic arch provides excellent and long-term patency rates with low morbidity, mortality, and secondary intervention rates. With an overall technical success of 98%, our results parallel those for lesions located more distally in the arch branches and support the continued use of percutaneous therapy for atherosclerotic disease throughout the arch branches.


Subject(s)
Atherosclerosis/surgery , Blood Vessel Prosthesis Implantation/instrumentation , Brachiocephalic Trunk/surgery , Carotid Artery, Common/surgery , Stents , Subclavian Artery/surgery , Aged , Arm/blood supply , Atherosclerosis/complications , Atherosclerosis/pathology , Atherosclerosis/physiopathology , Blood Vessel Prosthesis Implantation/adverse effects , Brachiocephalic Trunk/pathology , Brachiocephalic Trunk/physiopathology , Carotid Artery, Common/pathology , Carotid Artery, Common/physiopathology , Cerebrovascular Disorders/etiology , Cerebrovascular Disorders/surgery , Constriction, Pathologic , Female , Humans , Ischemia/etiology , Ischemia/surgery , Male , Middle Aged , Retrospective Studies , Severity of Illness Index , Subclavian Artery/pathology , Subclavian Artery/physiopathology , Time Factors , Treatment Outcome , Ultrasonography, Doppler, Duplex , Vascular Patency
12.
J Vasc Surg ; 46(5): 946-958; discussion 958, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17980281

ABSTRACT

BACKGROUND: Although aggressive endoluminal therapy for superficial femoral artery (SFA) occlusive disease is commonplace, the implications of diabetes mellitus (DM) on long-term outcomes in this population are unclear. We examined the consequences of endovascular treatment of the SFA in patients with and without DM. METHODS: A database of patients undergoing endovascular treatment of the SFA between 1986 and 2005 was maintained. Three groups were defined: nondiabetic patients, those with non-insulin-dependent DM (NIDDM), and those with insulin-dependent DM (IDDM). Intention-to-treat analysis was performed. Results were standardized to TransAtlantic Inter-Society Consensus (TASC) and Society for Vascular Surgery criteria. Time-dependent outcomes were assessed with Kaplan-Meier survival analyses. Factor analyses were performed using a Cox proportional hazard model for time-dependent variables. Data are presented as mean +/- SD where appropriate. RESULTS: Endovascular treatment (ie, balloon angioplasty +/- adjuvant stenting in 38%) was initiated in 525 limbs in 437 patients (68% male; average age, 66 +/- 14 years) for claudication failing conservative therapy or chronic critical limb ischemia (CLI). Of these, 50% were nondiabetic, 26% had NIDDM, and 24% had IDDM. Analyses were separated by those presenting with claudication (61%) and those presenting with CLI (39%). Among patients presenting with claudication, those with IDDM had significantly lower assisted primary patency (P < .01) and a higher incidence of restenosis (P = .04). Patencies at 3 years for nondiabetic, NIDDM, and IDDM were 62%, 72%, and 54% (primary), and 81%, 86%, and 65% (assisted primary), respectively. Patency and restenosis rates were associated with lesion calcification, TASC D lesion categorization, and acute periprocedural occlusion. Among patients presenting with CLI, patency and restenosis rates were equivalent across all groups; however, limb salvage was significantly worse for both groups of diabetic patients compared with nondiabetic (NIDDM, P = .01; IDDM, P = .02). Reduction in limb salvage rates was associated with presence of tissue loss at presentation, end-stage renal disease, and progression of distal disease on follow-up. CONCLUSIONS: Endoluminal therapy for SFA occlusive disease yields lower assisted patency rates and higher restenosis rates for those patients presenting with claudication who have more advanced diabetes (ie, IDDM). Among those patients presenting with CLI, particularly those with tissue loss, limb salvage rates are lowered for the diabetic groups (NIDDM and IDDM) despite equivalent patency and restenosis rates.


Subject(s)
Angioplasty, Balloon , Diabetic Angiopathies/therapy , Femoral Artery , Ischemia/therapy , Aged , Chronic Disease , Comorbidity , Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/therapy , Female , Heart Failure/epidemiology , Humans , Hyperlipidemias/epidemiology , Intermittent Claudication/therapy , Leg/blood supply , Limb Salvage , Male , Middle Aged , Stents , Vascular Patency
13.
Ann Vasc Surg ; 21(6): 663-70, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17980790

ABSTRACT

Current recommendations for follow-up after endovascular repair of abdominal aortic aneurysms (EVAR) include yearly computed tomographic (CT) scans after the first year. We hypothesize that this is unnecessary for patients who have aneurysm sacs that are stable or shrinking at 1 year and no evidence of endoleak. To explore this hypothesis, we reviewed the records of all patients undergoing EVAR at our institution who were implanted with grafts that are currently commercially available and had a minimum of 18 months' follow-up. Of 415 patients who underwent EVAR over an 8-year period, 93 met the entry criteria. At a mean follow-up of approximately 3 years, secondary interventions were required in 13%, 39%, and 25% of patients undergoing EVAR with Zenith, AneuRx, and Excluder devices, respectively, and secondary interventions after the first year were required in 3%, 22%, and 8% of such grafts, respectively. Seventy-one patients (76%) had aneurysm sacs that were stable or shrinking at 1 year and no endoleak. Only two of these patients subsequently required reintervention. Both patients had AneuRx grafts, and both problems could have easily been identified without CT scanning. Our data support the hypothesis that patients who meet these criteria at 1 year are unlikely to have problems that cannot be identified by ultrasound and/or clinical evaluation alone and, thus, that CT scans are not necessary after this point, especially in patients with Zenith or reengineered Excluder devices.


Subject(s)
Aortic Aneurysm, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis Implantation , Patient Selection , Tomography, X-Ray Computed , Aged , Aged, 80 and over , Algorithms , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/instrumentation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Postoperative Complications/diagnostic imaging , Postoperative Complications/surgery , Practice Guidelines as Topic , Predictive Value of Tests , Prosthesis Design , Reoperation , Time Factors , Treatment Outcome , Ultrasonography
14.
Ann Vasc Surg ; 21(4): 474-80, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17499964

ABSTRACT

The role of endovascular therapy for thrombosed dialysis access has grown despite the paucity of data on its viability. The purpose of this study was to characterize the outcomes of a universal endovascular dialysis declot policy at a tertiary medical center. A database of patients undergoing endovascular treatment of thrombosed dialysis access between 1997 and 2003 was maintained. A two-puncture, combined percutaneous mechanical and pharmacologic thrombectomy technique was used. Data were collected on the success rate, complication rate, long-term patency, and presence and location of stenosis. Fistulograms were reviewed in all cases to assess lesion characteristics and pre- and postprocedure results. Results were standardized to current Society of International Radiology and Society for Vascular Surgery criteria. Failure was considered as either an anatomic defect requiring therapy or loss of functionality of the fistula. Life-table analyses were performed to assess time-dependent outcomes. Cox's proportional hazard analyses were performed to identify factors associated with outcomes. Values are the mean +/- standard error of the mean. There were 114 patients (50% male; average age 58 years, range 21-78) who presented with 174 thrombosed grafts. Therapy was performed for 237 thrombotic events (median 2, range 1-5 thrombotic events per hemodialysis access). After successful declot, anastomotic venous stenoses were encountered in 72% and central venous stenoses in 18% of cases; no cause was found in 10%. All stenoses were treated with balloon angioplasty. The technical failure rate was 4.6%. The 30-day all-cause mortality rate was 1.7%, and major morbidity rate was 2.4%. There were 413 interventions (236 percutaneous transluminal angioplasty and/or 183 declot) performed to maintain patency, which amounted to 2.3 interventions per patient. Average primary functional dialysis life span was 6.7 months up to the primary thrombotic event. Aggressive endoluminal therapy added a further average of 12 months of functionality (defined as continued dialysis access). A universal policy of endovascular therapy for occluded dialysis access results in reestablishment of function in the majority of patients and will triple functional longevity. Furthermore, while this approach remains procedure-intensive, it carries low morbidity and mortality and preserves future sites of access.


Subject(s)
Angioplasty, Balloon , Arteriovenous Shunt, Surgical/adverse effects , Graft Occlusion, Vascular/therapy , Thrombectomy/methods , Adolescent , Adult , Aged , Aged, 80 and over , Comorbidity , Diabetic Nephropathies/epidemiology , Female , Heart Failure/epidemiology , Humans , Hypothyroidism/epidemiology , Kidney Failure, Chronic/epidemiology , Kidney Failure, Chronic/therapy , Life Tables , Male , Middle Aged , Proportional Hazards Models , Thrombophilia/epidemiology , Treatment Outcome , Vascular Patency
16.
J Am Coll Surg ; 202(6): 859-67, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16735198

ABSTRACT

BACKGROUND: Percutaneous therapy for symptomatic visceral occlusive disease is rapidly gaining popularity in many centers. This study evaluates the anatomic and functional outcomes of open and endovascular therapy for chronic mesenteric ischemia at an academic medical center. STUDY DESIGN: We performed a retrospective review of patients who underwent endovascular or open mesenteric arterial revascularization for chronic mesenteric ischemia between January 1989 and September 2003. Indications for revascularization included postprandial abdominal pain (92%) or weight loss (54%). All had atherosclerotic visceral occlusive disease with a median of 2 vessels with more than 50% stenosis or occlusion on angiography. Sixty patients (44 women, mean age 66 years) underwent 67 interventions (43 vessels bypassed, 23 vessel endarterectomies, 22 vessel angioplasty and stents). The median numbers of vessels revascularized were two in the open group and one in the endovascular group. RESULTS: Thirty-day mortality and cumulative survival at 3 years were similar (open, 15% and 62% +/- 9%; endovascular, 21% and 63%+/-14%, respectively; p=NS). Cumulative patencies at 6 months were 83%+/-7% and 68%+/-14% in the open and endovascular groups, respectively (p=NS). Major morbidity, median postoperative length of stay, and cumulative freedom from recurrent symptoms at 6 months were significantly greater in the open group (open, 46%, 23 days, and 71%+/-7%, respectively; endovascular, 19%, 1 day, and 34%+/-10%, respectively; p < 0.01). CONCLUSIONS: Endovascular revascularization is attractive because it carries equivalent patency to open revascularization. Symptomatic benefit of endovascular revascularization is not achieved, probably as a result of incomplete revascularization. Despite incomplete revascularization, endovascular therapy has equivalent survival and lower morbidity compared with open revascularization. Complete endovascular revascularization needs further evaluation to determine if it is superior to open revascularization. In the interim, endovascular therapy should be reserved for the patient unable to undergo open revascularization.


Subject(s)
Angioplasty/methods , Angioscopy/methods , Mesenteric Vascular Occlusion/surgery , Adult , Aged , Aged, 80 and over , Chronic Disease , Female , Follow-Up Studies , Humans , Magnetic Resonance Angiography , Male , Mesenteric Arteries/diagnostic imaging , Mesenteric Arteries/pathology , Mesenteric Arteries/surgery , Mesenteric Vascular Occlusion/diagnosis , Middle Aged , Retrospective Studies , Time Factors , Tomography, X-Ray Computed , Treatment Outcome
17.
J Vasc Surg ; 42(5): 951-6, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16275453

ABSTRACT

BACKGROUND: The Dialysis Outcomes Quality Initiative (DOQI)-inspired push to create autogenous fistulas has led to a resurgence of interest in basilic vein transposition as an autogenous access conduit. We reviewed our experience with autogenous brachial-basilic upper arm transpositions (BTX) to clarify current maturation and patency rates and provide realistic expectations for a tertiary referral vascular practice. METHODS: We follow an aggressive "all-autogenous" policy with regard to dialysis access and recommend BTX when all cephalic options are exhausted. Prosthetic grafts are not attempted unless all upper extremity veins are unusable. The records of all patients undergoing autogenous basilic and brachial vein upper arm transpositions for hemodialysis access between April 2001 and December 2004 were retrospectively evaluated. Mean follow-up was 10 months (range, 0 to 38 months). RESULTS: Eighty-seven patients underwent 100 basilic and 3 brachial vein transpositions. Most of the patients were already receiving hemodialysis (83%), with a mean of 1.1 (range, 0 to 4) previous access attempts. Perioperative complications included 1 death secondary to a myocardial infarction, 7 hematomas (4 requiring reoperation), and 6 infections (2 requiring reoperation). Steal syndrome developed in five patients. Maturation rate was 79%. Functional primary and secondary patency rates were 23% +/- 5% and 47% +/- 6% at 1 year and 11% +/- 5% and 40% +/- 10% at 2 years, respectively (mean +/- SE). The most common causes of failure for a matured fistula were stenosis within the body of the basilic vein (44%) followed by central venous outflow stenosis (20%). No preoperative variable, including gender, age, diabetes mellitus, presence of ipsilateral hemodialysis catheter, number of previous access attempts, maximal or minimal vein diameter, or obesity, had a significant impact on rate of maturation or long term patency. CONCLUSIONS: In our experience, autogenous brachial-basilic upper arm transposition fistulas have initial maturation rates that exceed DOQI guidelines, but disappointing short- to medium-term patency rates. Although these outcomes were obtained within the context of an aggressive all-autogenous policy, the poor durability of these transpositions should prompt further investigation of current access algorithms.


Subject(s)
Arteriovenous Shunt, Surgical/methods , Axillary Vein/transplantation , Brachial Artery/surgery , Renal Dialysis/instrumentation , Societies, Medical , Adolescent , Adult , Aged , Aged, 80 and over , Axillary Vein/diagnostic imaging , Brachial Artery/diagnostic imaging , Child , Female , Follow-Up Studies , Humans , Male , Middle Aged , Reoperation , Retrospective Studies , Transplantation, Autologous , Treatment Outcome , Ultrasonography, Doppler, Duplex , United States , Vascular Patency
18.
Ann Vasc Surg ; 19(6): 787-92, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16228807

ABSTRACT

Although the long-term (>30 days) effects of endoluminal treatment of superficial femoral artery (SFA) disease have been well studied, the implications of early (< or =30 days) failure are still unclear. We examined the consequences of early failure after endovascular treatment of the SFA. We anticipate that early failure will not be associated with significant morbidity and mortality and will not interfere with surgical bypass options. A prospective database of patients undergoing endovascular treatment of the SFA between 1986 and 2004 was maintained. Intention-to-treat analysis was performed. Angiograms were reviewed in all cases to assess lesion characteristics and pre- and post procedure runoff. Results were standardized to current Transatlantic Intersociety Consensus (TASC) and Society for Vascular Surgery (SVS) criteria. There were 441 limbs in 360 patients (70% male, average age 65 years) that underwent endovascular treatment. There was early failure in 39 procedures (8%). Twenty-nine cases (74%) failed immediately (<24 hr), and 10 cases (26%) failed within the first 30 days following intervention. Factors that predicted failure were TASC category D and preprocedural SVS symptom grade > or =5. The 90-day mortality in the group was 0%, and major morbidity was 4%. No emergent endovascular intervention, bypass, or unplanned amputation occurred within 30 days of these failures. There was no change in the level of amputation or the level of distal anastomosis of a bypass graft as a result of an early failure. Early failure of endoluminal therapy for SFA disease is not associated with significant morbidity and mortality. Options for surgical bypass are not compromised, and the amputation level is not altered. Aggressive endoluminal approaches to SFA disease should be considered as a first-line therapy in all patients.


Subject(s)
Arterial Occlusive Diseases/surgery , Blood Vessel Prosthesis Implantation , Femoral Artery/surgery , Aged , Female , Graft Occlusion, Vascular , Humans , Limb Salvage , Male , Retrospective Studies , Treatment Failure
19.
J Endovasc Ther ; 12(5): 574-8, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16212457

ABSTRACT

PURPOSE: To report our early experience with the endovascular placement of stacked Zenith main body extensions (cuffs) in the treatment of focal thoracic aortic pathology in high-risk patients. METHODS: Between January 2003 and May 2004, 6 patients (3 men; mean age 59 years, range 37-82) with focal aortic pathology underwent endovascular repair using stacked 30 and 32-mm-diameter Zenith main body extensions. The setting was a university tertiary referral center for vascular disease. Indication for treatment included 2 descending thoracic aneurysms and individual cases of traumatic thoracic tear, diverticulum of Kommerell, thoracic pseudoaneurysm, and aortoesophageal fistula. RESULTS: All procedures were performed successfully, with a mean of 3 cuffs used. The patient with an aortoesophageal fistula expired after successful cuff placement due to sequela of massive pretreatment hemorrhage; fistula coverage was confirmed at autopsy. There were no type I endoleaks. Morbidity included an occluded right subclavian artery from traumatic passage of the device through the artery. No left subclavian arteries were covered. No neurological deficits or paraplegia was observed. The cuffs were patent in all surviving patients at an average follow-up of 7 months (range 3-12). Computed tomography in all survivors confirmed adequate cuff placement, absence of endoleak, and lack of cuff migration. Based on this experience, the following technical recommendations are offered: (1) right subclavian cutdown when needed to reach a lesion beyond the range of the sheath, (2) Dacron chimney placement, (3) stiff guidewire usage, (4) wire placement from the right subclavian artery through the common femoral artery if necessary to ease a sharp bend in the arch, and (5) cuff overlap of 25% to 50%. CONCLUSIONS: In high-risk patients, focal aortic pathology can be successfully treated with off-the-shelf commercially available cuffs using a stacking technique with acceptable mortality, morbidity, and short-term durability.


Subject(s)
Aortic Aneurysm, Thoracic/surgery , Blood Vessel Prosthesis , Adult , Aged , Aged, 80 and over , Aneurysm, False/diagnostic imaging , Aneurysm, False/physiopathology , Aneurysm, False/surgery , Aortic Aneurysm, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/physiopathology , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis Implantation/methods , Diverticulum/diagnostic imaging , Diverticulum/physiopathology , Diverticulum/surgery , Esophageal Fistula/diagnostic imaging , Esophageal Fistula/physiopathology , Esophageal Fistula/surgery , Female , Femoral Artery/diagnostic imaging , Femoral Artery/pathology , Femoral Artery/physiopathology , Femoral Artery/surgery , Follow-Up Studies , Humans , Male , Middle Aged , Postoperative Complications/diagnostic imaging , Postoperative Complications/etiology , Postoperative Complications/mortality , Prosthesis Design , Retrospective Studies , Stents , Subclavian Artery/diagnostic imaging , Subclavian Artery/pathology , Subclavian Artery/physiopathology , Subclavian Artery/surgery , Survival Rate , Tomography, X-Ray Computed , Treatment Outcome , Vascular Patency/physiology
20.
Vasc Endovascular Surg ; 39(5): 393-400, 2005.
Article in English | MEDLINE | ID: mdl-16193211

ABSTRACT

Modern therapy, including endoluminal procedures and improved medical management, still yield less than desired results for tibial vessel occlusive disease. Despite the recent focus on these newer interventions, few modern series have evaluated the efficacy of popliteal-to-distal bypass procedures. The authors aimed to determine the efficacy of popliteal-distal bypass and to identify adverse prognostic factors for ultimate limb salvage. Eighty-seven patients (54 men; average age: 63 years) underwent 92 popliteal-distal bypasses. Duplex ultrasound was utilized to assess patency of all grafts. Data were analyzed by life-table analysis to determine patency rates at postoperative intervals. Median patient follow-up was 2.4 years. Major indications for bypass included chronic limb ischemia (86%) and disabling claudication (8%); 62% of the limbs were considered threatened, and 74% of the proximal anastomoses were above-knee. All procedures were technically successful. There were no perioperative (< 30 days) deaths, and 86% of patients were alive at 5 years. Cumulative patency rates were 74% at 6 months, 70% at 2 years, and 63% at 5 years. Limb salvage rates closely paralleled patency rates. At 5 years, 62% of the affected limbs were intact; 72% of the limbs lost were associated with early (< 180 days) bypass failures. Predictors of limb loss included early graft failure (84 days vs 1,288 days, p < 0.0001), younger age (57 years vs 64 years, p = 0.039), history of previous ipsilateral vascular procedures (50% vs 21%, p = 0.03), heavy (> 1 ppd) tobacco use (p = 0.001), and a thrombosed femoral-popliteal bypass at presentation (p = 0.002). When successful, popliteal-distal bypass is associated with excellent long-term patency and limb salvage rates. Early failures are often associated with limb loss. Heavy tobacco use, younger age, early graft failures, repeat revascularization, and presentation with a thrombosed femoral-popliteal graft are associated with limb loss.


Subject(s)
Blood Vessel Prosthesis Implantation , Lower Extremity/blood supply , Popliteal Artery/surgery , Tibial Arteries/surgery , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Arterial Occlusive Diseases/diagnostic imaging , Arterial Occlusive Diseases/mortality , Arterial Occlusive Diseases/surgery , Female , Femoral Artery/surgery , Follow-Up Studies , Graft Occlusion, Vascular/diagnostic imaging , Humans , Intermittent Claudication/diagnostic imaging , Intermittent Claudication/mortality , Intermittent Claudication/surgery , Ischemia/diagnostic imaging , Ischemia/mortality , Ischemia/surgery , Life Tables , Lower Extremity/diagnostic imaging , Lower Extremity/physiopathology , Male , Middle Aged , Popliteal Artery/diagnostic imaging , Popliteal Artery/physiopathology , Prosthesis Failure , Retrospective Studies , Risk Factors , Salvage Therapy , Survival Analysis , Tibial Arteries/diagnostic imaging , Tibial Arteries/physiopathology , Ultrasonography, Doppler, Duplex , Vascular Patency
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