ABSTRACT
BACKGROUND: Staghorn stone is considered as a dreadful type of renal stones. The choice of the best treatment is always difficult. AIM: To evaluate the results of percutaneous nephrolithotomy in the treatment of staghorn stones. METHODS: We report 83 cases of staghorn stones that were treated by percutaneous nephrolithotomy during a period of 10 years from 1994 to 2004. RESULTS: The mean age was 44 years and sex-ratio was 2,2. The right kidney was treated alone in 42% of cases, the left one in 56% of cases and both kidneys in only two cases. The mean area of stones was 6,6 cm2. One renal punction was necessary in 97% of cases. The rate of stone free after percutaneous nephrolithotomy only was about 54% and when combined with lithotripsy the rate was 64%. CONCLUSION: Combined treatment using percutaneous nephrolithotomy and lithotripsy is considered as the best procedure for staghorn stones treatment.
Subject(s)
Kidney Calculi/surgery , Lithotripsy, Laser/methods , Nephrostomy, Percutaneous/methods , Adult , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment OutcomeABSTRACT
In our cohort, FGFR3 mutations were detected in 31.1% of bladder tumors and are associated with lower stage and grade. Concerning TP53, 62 mutations were found in tumors from 44 cases (48.88%) and are associated with advanced forms. The combined analysis of FGFR3 and TP53 mutations in our cohort showed an independent distribution. In addition, we have reported that FGFR3 mutations spectrum depends on the intensity of tobacco use (pack years: PY). Finally, we have found that the FGFR3wt/TP53mut genotype, which was associated with advanced bladder tumors; was overrepresented in light smokers (PY < 40) compared to nonsmoker patients (p =.01).
Subject(s)
Black People/genetics , Carcinoma/etiology , Mutation , Receptor, Fibroblast Growth Factor, Type 3/genetics , Smoking/adverse effects , Tumor Suppressor Protein p53/genetics , Urinary Bladder Neoplasms/etiology , Aged , Carcinoma/ethnology , Carcinoma/genetics , Carcinoma/pathology , Exons , Female , Gene Expression Regulation, Neoplastic , Genetic Predisposition to Disease , Humans , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Odds Ratio , Phenotype , Risk Assessment , Risk Factors , Smoking/ethnology , Tunisia/epidemiology , Urinary Bladder Neoplasms/ethnology , Urinary Bladder Neoplasms/genetics , Urinary Bladder Neoplasms/pathology , Urothelium/pathologyABSTRACT
BACKGROUND: Seminal vesicle abscess (SVA) is a rare pathologic entity, usually diagnosed by transrectal ultrasonography and computerized tomography scan. AIM: Report a new case. CASE REPORT: We report the successful management of a seminal vesicle abscess with percutaneous transvesical drainage in a 60-year-old diabetic patient. Computed tomography scan has been used for the diagnosis and the guidance of the percutaneous drainage. CONCLUSION: Seminal vesicle abscess is a very rare pathology with no specific symptoms. Transvesical drainage can be proposed successfully.
Subject(s)
Abscess , Diabetes Complications , Seminal Vesicles , Abscess/diagnosis , Abscess/diagnostic imaging , Abscess/etiology , Abscess/surgery , Drainage , Follow-Up Studies , Humans , Male , Middle Aged , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , UltrasonographyABSTRACT
BACKGROUND: Pure squamous cell carcinoma (SCC) is a rare entity in Western countries. The management of SCC still remains similar to that of transitional carcinoma, although it is a different entity. A retrospective review is helpful in understanding the epidemiologic aspects, pathogenesis, and treatment and prognosis of schistosoma-unrelated SCC. PATIENTS AND METHODS: Between 1987 and 2002, 30 men and 3 women had been treated for pure SCC of the bladder, not related to bilharzias. RESULTS: The mean age of patients was 59 years (range, 29-83 years). They constitute 1.2% of all bladder tumors. At presentation, 2 patients had a distant metastasis. Eleven patients (34%) had a bladder stone with recurrent urinary tract infection; they had been treated since age 6-17 years. Twenty-one patients underwent radical cystectomy, followed by chemotherapy in 2 cases. At a mean follow-up of 5 years, 14 patients (66.6%) died of locoregional disease, with associated metastasis in 5 cases. Seven patients (33.3%) are alive without any evidence of disease. The survival rate was correlated with tumor stage. CONCLUSION: The unrelated SCC has an unfavorable prognosis, mostly caused by the locally advanced disease at the time of presentation. Distant metastases are not rare. The transfer of novel chemotherapy regimens and preoperative radiation therapy should be considered because pelvic recurrences are the leading cause of progression in SCC.