[Association of adenocarcinoma of esophagus and breast cancer in a male with Madelung' disease]. / Asociación de adenocarcinoma de esófago y cáncer de mama en un varón con enfermedad de Madelung.

The development of a cancer of the esophagus in women who previously had received radiotherapy for breast cancer is a known although infrequent event. The risk of apparition of the second neoplasia is greater in women who survive at least ten years after the exposition to the radiation. Squamous cell carcinoma is the histological subtype more frequent. We report a case of adenocarcinoma of the esophagus in a man diagnosed of benign symmetrical lipomatosis (Madelung' disease), who had received adjuvant radiotherapy three years before for breast cancer.

Asociación de adenocarcinoma de esófago y cáncer de mama en un varón con enfermedad de Madelung / Association of adenocarcinoma of esophagus and breast cancer in a male with Madelung´ disease

La aparición de un cáncer de esófago en mujeres que previamente han recibido radioterapia como tratamiento de un cáncer de mama es un hecho conocido aunque poco frecuente. El riesgo de aparición de la segunda neoplasia es mayor cuando han transcurrido diez o más años desde la exposición a la radiación. La estirpe histológica de la neoplasia de esófago más frecuente es la de carcinoma de células escamosas. Se presenta un caso de adenocarcinoma de esófago en un varón, diagnosticado de lipomatosis bilateral simétrica o enfermedad de Madelung, que recibió radioterapia tres años antes por presentar un cáncer de mama

The development of a cancer of the esophagus in women who previously had received radiotherapy for breast cancer is a known although infrequent event. The risk of apparition of the second neoplasia is greater in women who survive at least ten years after the exposition to the radiation. Squamous cell carcinoma is the histological subtype more frequent. We report a case of adenocarcinoma of the esophagus in a man diagnosed of benign symmetrical lipomatosis (Madelung’ disease), who had received adjuvant radiotherapy three years before for breast cancer

[Multiple malignant neoplasms in patients with prostate tumours in the health district of Leon]. / Neoplasias malignas múltiples en pacientes con cáncer de próstata en el área sanitaria de León.

OBJECTIVE: We analyze the characteristics of the patients with prostate tumours who developed a multiple malignant primary neoplasms (MMPN) in the health district of León, the impact on survival and the prognostic variables. MATERIAL AND METHODS: We have used the data from the Tumour Registry of the Hospital of León and we have selected all those patients who were diagnosed of a prostate tumor between 1993 and 2002. Later we made two groups: the first with 67 patients with MMPN and a second group with 145 patients with single prostate tumours diagnosed during 1996 and 1997. RESULTS: Prevalence of MMPM was of 5.57 percent. Patients with MMPN were 3 years younger than those with single tumours, with a high frequency (41 percent) of familial oncologic antecedents on first degree parents. The more frequent association was the synchronous urologic neoplasm. During the next two years from diagnosed of prostate tumour, 86 percent of patients with MMPN were diagnosed of their second neoplasm. Survival of metachronous MMPN patients was lower than synchronous MMPN patients, being the variables with prognosis significance the age, metachronous MMPN, stage of second neoplasms and if the second neoplasms was or not urologic. CONCLUSIONS: MMPN in patients with prostatic tumours are frequent in our medium. A genetic base may be associated in these patients. Prognosis of metachronous MMPN patients is worse. No differences were observed about prognosis with single tumour patients.

Neoplasias malignas múltiples en pacientes con cáncer de próstata en el área sanitaria de León / Multiple malignant neoplasms in patients with prostate tumors in the health district of Leon

Objetivos: Analizar las características de los pacientes con tumores prostáticos que desarrollaron una neoplasia primaria maligna múltiple (NPMM) en el área sanitaria de León, el impacto sobre la supervivencia y las posibles variables pronósticas. Material y métodos: Utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores prostáticos diagnosticados entre 1993 y 2002, creando dos grupos: el primero constituido por 67 pacientes con NPMM y el segundo formado por 145 pacientes con tumores únicos diagnosticados entre 1996 y 1997. Resultados: La prevalencia de NPMM fue del 5,57%. Los pacientes con NPMM fueron 3 años más jóvenes que los pacientes con tumores únicos, con una elevada proporción (41%) de antecedentes familiares oncológicos en familiares de primer grado. La asociación más frecuente fue el cáncer urológico sincrónico. El 86% de los pacientes fueron diagnosticados del segundo tumor en los primeros dos años. La supervivencia de los pacientes con NPMM metacrónicas fue inferior a la de los pacientes con NPMM sincrónicas, siendo las variables con significación pronóstica la edad, el padecimiento de una NPMM metacrónica, el estadio del segundo tumor y el padecimiento de un segundo tumor urológico. Conclusiones: Las NPMM en pacientes con tumores prostáticos son relativamente frecuentes en nuestro medio. Parece existir una base genética en estos pacientes. El pronóstico de los pacientes con NPMM metacrónicas es peor. No existen diferencias significativas en cuanto al pronóstico con respecto a los pacientes con tumores únicos

Objetive: We analize the characteristics of the patients with prostate tumours who developed a multiple malignant primary neoplasms (MMPN) in the health district of León, the impact on survival and the prognostic variables. Material and methods: We have used the data from the Tumour Registry of the Hospital of León and we have selected all those patients who were diagnosed of a prostate tumor between 1993 and 2002. Later we made two groups: the first with 67 patients with MMPN and a second group with 145 patients with single prostate tumours diagnosed during 1996 and 1997. Results: Prevalence of MMPM was of 5.57 percent. Patients with MMPN were 3 years younger than those with single tumours, with a high frecuency (41 percent) of familial oncologic antecedents on first degree parents. The more frequent association was the synchronous urologic neoplasm. During the next two years from diagnosed of prostate tumour, 86 percent of patients with MMPN were diagnosed of their second neoplasm. Survival of metachronous MMPN patients was lower than synchronous MMPN patients, being the variables with prognosis significance the age, metachronous MMPN, stage of second neoplasms and if the second neoplasms was or not urologic. Conclusions: MMPN in patients with prostatic tumours are frequent in our medium. A genetic base may be associated in these patients. Prognosisof metachronous MMPN patients is worse. No differences were observed about prognosis with single tumour patients

Varix of the heart causing outflow tract obstruction.

We report a case about a neonate who died of severe subaortic stenosis due to a giant vascular dilation of the left ventricular outflow tract. We emphasize the fatal result of this benign lesion and make differential diagnosis with haemangiomas and valvular blood cysts.

Subcutaneous fat necrosis of newborn children.

We report a case of subcutaneous fat necrosis of a newborn child which appeared 9 days after birth and was cured without any complications. We propose the reclassification of the etiological factors accompanying this lesion by classifying them in a plurietiological syndrome with some basic or essential factors and other causative factors.