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1.
Metabolites ; 13(7)2023 Jul 24.
Article in English | MEDLINE | ID: mdl-37512587

ABSTRACT

Brazil has the second-highest COVID-19 death rate worldwide, and Rio de Janeiro is among the states with the highest rate in the country. Although vaccine coverage has been achieved, it is anticipated that COVID-19 will transition into an endemic disease. It is concerning that the molecular mechanisms underlying clinical evolution from mild to severe disease, as well as the mechanisms leading to long COVID-19, are not yet fully understood. NMR and MS-based metabolomics were used to identify metabolites associated with COVID-19 pathophysiology and disease outcome. Severe COVID-19 cases (n = 35) were enrolled in two reference centers in Rio de Janeiro within 72 h of ICU admission, alongside 12 non-infected control subjects. COVID-19 patients were grouped into survivors (n = 18) and non-survivors (n = 17). Choline-related metabolites, serine, glycine, and betaine, were reduced in severe COVID-19, indicating dysregulation in methyl donors. Non-survivors had higher levels of creatine/creatinine, 4-hydroxyproline, gluconic acid, and N-acetylserine, indicating liver and kidney dysfunction. Several changes were greater in women; thus, patients' sex should be considered in pandemic surveillance to achieve better disease stratification and improve outcomes. These metabolic alterations may be useful to monitor organ (dys) function and to understand the pathophysiology of acute and possibly post-acute COVID-19 syndromes.

2.
Rev. Soc. Bras. Med. Trop ; 54: e20200066, 2021. tab, graf
Article in English | Sec. Est. Saúde SP, Coleciona SUS, LILACS | ID: biblio-1136919

ABSTRACT

Abstract INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.


Subject(s)
Humans , Male , Pregnancy , Adult , Human T-lymphotropic virus 1/genetics , HTLV-I Infections/diagnosis , HTLV-I Infections/epidemiology , HTLV-II Infections/diagnosis , HTLV-II Infections/epidemiology , Phylogeny , Brazil/epidemiology , Human T-lymphotropic virus 2/genetics
3.
Rev Soc Bras Med Trop ; 54: e20200066, 2020.
Article in English | MEDLINE | ID: mdl-33206874

ABSTRACT

INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.


Subject(s)
HTLV-I Infections , HTLV-II Infections , Human T-lymphotropic virus 1 , Adult , Brazil/epidemiology , HTLV-I Infections/diagnosis , HTLV-I Infections/epidemiology , HTLV-II Infections/diagnosis , HTLV-II Infections/epidemiology , Human T-lymphotropic virus 1/genetics , Human T-lymphotropic virus 2/genetics , Humans , Male , Phylogeny
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