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1.
Studies on the cholinergic receptor. 6. Synthesis and muscarinic activity of 2-methyl-4-(2-dimethylaminoethyl)-1,3-dioxolane methiodide.
Chang, K J; Ridley, H F; Triggle, D J.
J Med Chem ; 14(12): 1237, 1971 Dec.
Article in English | MEDLINE | ID: mdl-5116244

Subject(s)
Dioxoles/chemical synthesis , Parasympathomimetics/chemical synthesis , Receptors, Drug , Amines/chemical synthesis , Iodine , Magnetic Resonance Spectroscopy , Methylamines/chemical synthesis , Quaternary Ammonium Compounds/chemical synthesis , Receptors, Cholinergic , Structure-Activity Relationship
2.
Studies on the cholinergic receptor. IV. The synthesis and muscarinic activity of 3,7-dimethyl-2,4-dioxo-7-azaspiro[3.4]octane methiodide.
Ridley, H F; Chatterjee, S S; Moran, J F; Triggle, D J.
J Med Chem ; 12(5): 931-3, 1969 Sep.
Article in English | MEDLINE | ID: mdl-5812223

Subject(s)
Iodides , Parasympathomimetics/pharmacology , Spiro Compounds , Animals , Chemical Phenomena , Chemistry , Hexamethonium Compounds/pharmacology , Ileum/drug effects , Iodides/analysis , Iodides/chemical synthesis , Iodides/pharmacology , Rats , Sensory Receptor Cells , Spiro Compounds/analysis , Spiro Compounds/chemical synthesis , Spiro Compounds/pharmacology
3.
Studies on the cholinergic receptor. 3. Parasympatholytic properties of cis- and trans- 4-dimethylaminomethyl-2-phenyl-1, 3-dioxolane methiodide.
May, M; Ridley, H F; Triggle, D J.
J Med Chem ; 12(2): 320-1, 1969 Mar.
Article in English | MEDLINE | ID: mdl-5783610

Subject(s)
Dioxoles/chemical synthesis , Parasympatholytics/chemical synthesis , Binding Sites
4.
Some 3-alkoxyestra-1,3,5(10)-trien-17-beta-ols.
Triggle, D J; Ridley, H F; DeMaio, D M.
J Med Chem ; 12(2): 346, 1969 Mar.
Article in English | MEDLINE | ID: mdl-5783620

Subject(s)
Estrogens/chemical synthesis , Estradiol
5.
Studies on the cholinergic receptor. II. Monosubstituted and bicyclic derivatives of cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide.
Garrison, D R; May, M; Ridley, H F; Triggle, D J.
J Med Chem ; 12(1): 130-4, 1969 Jan.
Article in English | MEDLINE | ID: mdl-5763009

Subject(s)
Bridged-Ring Compounds/chemical synthesis , Dioxoles/chemical synthesis , Parasympathomimetics/chemical synthesis , Sensory Receptor Cells , Animals , Anura , Binding Sites , Bridged-Ring Compounds/pharmacology , Chemical Phenomena , Chemistry , Dioxoles/pharmacology , Iodides , Jejunum , Magnetic Resonance Spectroscopy , Muscles/drug effects , Muscles/physiology , Parasympathomimetics/pharmacology , Quaternary Ammonium Compounds , Rats , Stereoisomerism
6.
Compounds affecting the central nervous system. IV. Substituted 2-benzyl-3-dialkylaminoalkylindenes and related compounds.
Ganellin, C R; Loynes, J M; Ridley, H F; Spickett, R G.
J Med Chem ; 10(5): 826-33, 1967 Sep.
Article in English | MEDLINE | ID: mdl-4383005

Subject(s)
Analgesics/pharmacology , Central Nervous System/drug effects , Indenes/chemical synthesis , Indenes/pharmacology , Amines , Animals , Histamine H1 Antagonists/pharmacology , Mice
7.
The synthesis of tertiary arylalkylamines from aryl Grignard reagents.
Bavin, P M; Ganellin, C R; Loynes, J M; Miles, P D; Ridley, H F.
J Med Chem ; 9(5): 790-1, 1966 Sep.
Article in English | MEDLINE | ID: mdl-5969063

Subject(s)
Amines , Indicators and Reagents , Chemistry, Organic , Organic Chemistry Phenomena
8.
Some hydrazine derivatives of (4-biphenyl)glyoxal.
Durant, G J; Ridley, H F; Spickett, R G.
J Med Chem ; 9(5): 792-3, 1966 Sep.
Article in English | MEDLINE | ID: mdl-4291026

Subject(s)
Glyoxylates , Hydrazines , Chemistry, Organic , Glyoxylates/pharmacology , Hydrazines/pharmacology , Organic Chemistry Phenomena , Orthomyxoviridae/drug effects , Simplexvirus/drug effects
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