ABSTRACT
Benign pancreatic hyperenzymemia, also known as Gullo's syndrome, is a little-known syndrome first described in 1996 in patients studied for an elevation of pancreatic enzymes while otherwise being asymptomatic. We describe the case of a 2-year-old patient who was found to have significant elevation of amylase and lipase levels while he was asymptomatic. Blood tests and imaging tests were performed to determine the etiology, but they gave normal results. The enzyme elevation can even be 10 times the normal value of the enzyme, and only 1 enzyme may elevate, although most often all pancreatic enzymes are elevated. The etiology is not known, although several hypotheses have been suggested. This enzyme elevation is described both in adults and children and also sporadically or with a familial pattern. Knowledge of it can limit the performance of the multiple complementary test, some of which are very invasive in patients who have elevated pancreatic enzymes while they are asymptomatic. It knowledge allows us to confirm a benign prognosis about it and reassure the family about this disease and that in the end it will not require aggressive treatments such as surgery or chemotherapy.
Subject(s)
Amylases/blood , Lipase/blood , Pancreatic Diseases/enzymology , Amylases/urine , Asymptomatic Diseases , Child, Preschool , Humans , Lipase/urine , Male , Pancreatic Diseases/blood , Pancreatic Diseases/diagnosis , Pancreatic Diseases/urineABSTRACT
No disponible
Subject(s)
Child , Humans , Male , Adenocarcinoma/congenital , Adenocarcinoma/metabolism , Helicobacter pylori/cytology , Helicobacter pylori/enzymology , Pediatrics , Asthenia/pathology , Adenocarcinoma/complications , Adenocarcinoma/pathology , Helicobacter pylori/classification , Helicobacter pylori/metabolism , Pediatrics/methods , Asthenia/complicationsABSTRACT
Collagenous gastritis (CG) is an uncommon condition known in the pediatric age. It is characterized by the presence of subepithelial collagen bands (> 10 microm) associated with lymphoplasmacytic infiltration of the stomach's lamina propria. Symptoms manifested by patients with CG may be common with many other disorders. It typically manifests with epigastralgia, vomiting, and iron deficiency during pre-adolescence. This condition's pathophysiology remains unclear. In contrast to adults, where association with collagenous colitis and other autoimmune conditions is more common, pediatric involvement is usually confined to the stomach. Drugs of choice include proton pump inhibitors and corticoids. A case is reported of a 12-year-old girl with abdominal pain and ferritin deficiency who was diagnosed with CG based on gastric biopsy and experienced a favorable outcome.
Subject(s)
Gastritis/diagnosis , Stomach/pathology , Biopsy , Child , Female , Gastritis/pathology , HumansABSTRACT
La gastritis colágena (GC) es una entidad poco frecuente y conocida en edad pediátrica. Se caracteriza por la presencia de bandas de colágeno subepiteliales (> 10 μm) asociadas a infiltrado linfoplasmocitario en la lámina propia del estómago. La sintomatología que presentan los pacientes afectos de GC puede ser común a muchas otras patologías. Se manifiesta típicamente con epigastralgia, vómitos y ferropenia en la pre-adolescencia. La fisiopatología de esta entidad no está del todo clara. La afectación suele ser únicamente gástrica, a diferencia del adulto, más asociado a colitis colágena y otras entidades autoinmunes. Los fármacos de elección son los inhibidores de la bomba de protones (IBP) y los corticoides. Se presenta un caso clínico de una niña de 12 años con abdominalgia y ferritinopenia diagnosticada de GC por las biopsias gástricas con evolución clínica favorable
Collagenous gastritis (CG) is an uncommon condition known in the pediatric age. It is characterized by the presence of subepithelial collagen bands (> 10 μm) associated with lymphoplasmacytic infiltration of the stomach's lamina propria. Symptoms manifested by patients with CG may be common with many other disorders. It typically manifests with epigastralgia, vomiting, and iron deficiency during pre-adolescence. This condition's pathophysiology remains unclear. In contrast to adults, where association with collagenous colitis and other autoimmune conditions is more common, pediatric involvement is usually confined to the stomach. Drugs of choice include proton pump inhibitors and corticoids. A case is reported of a 12-year-old girl with abdominal pain and ferritin deficiency who was diagnosed with CG based on gastric biopsy and experienced a favorable outcome