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Physiol Meas ; 29(5): 669-83, 2008 May.
Article in English | MEDLINE | ID: mdl-18460752

ABSTRACT

An algorithm is presented to determine the Cole-Cole parameters of electrical impedivity using only measurements of its real part. The algorithm is based on two multi-fold direct inversion methods for the Cole-Cole and Debye equations, respectively, and a genetic algorithm for the optimization of the mean square error between experimental and calculated data. The algorithm has been developed to obtain the Cole-Cole parameters from experimental data, which were used to screen cervical intra-epithelial neoplasia. The proposed algorithm was compared with different numerical integrations of the Kramers-Kronig relation and the result shows that this algorithm is the best. A high immunity to noise was obtained.


Subject(s)
Algorithms , Diagnosis, Computer-Assisted/methods , Plethysmography, Impedance/methods , Uterine Cervical Dysplasia/diagnosis , Electric Impedance , Female , Humans , Reproducibility of Results , Sensitivity and Specificity
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