ABSTRACT
to determine the value of dopamine transporter (DAT) neuroimaging radiotracer in a group of idiopathic rapid eye movement sleep behavior disorder (iRBD) patients regarding the development of a synucleinopathy. Methods: 6 retrospectively selected patients with clinical and polysomnographic diagnosis of iRBD, on treatment or not, were submitted to a single-photon emission computerized tomography (SPECT) with TRODAT. Results: Five from six patients have an abnormal test showing reduction in DAT density measured by the linkage potential on SPECT. Conclusions: TRODAT crosses the blood brain barrier, has a high affinity for DAT and is capture by SPECT. The decreased uptake of DAT tracers means a reduction in dopaminergic activity which suggest the possibility of Parkinson Disease. We have tried to reinforce iRBD as a marker of neurodegenerative disease and suggest SPECT with TRODAT as an easy method in our country to follow longitudinally these patients.
ABSTRACT
The Consensus on restless legs syndrome is an effort of neurologists from several Brazilian states, which tirelessly reviewed the literature of recent years in search of evidence, both in regard to diagnosis and treatment, according to the Oxford Centre for Evidence-based Medicine.
Subject(s)
Restless Legs Syndrome/diagnosis , Restless Legs Syndrome/therapy , Brazil , Calcium Channel Blockers/therapeutic use , Consensus , Diagnosis, Differential , Dopamine Agonists/therapeutic use , Evidence-Based Medicine , Humans , Restless Legs Syndrome/complications , Restless Legs Syndrome/physiopathologyABSTRACT
The Consensus on restless legs syndrome is an effort of neurologists from several Brazilian states, which tirelessly reviewed the literature of recent years in search of evidence, both in regard to diagnosis and treatment, according to the Oxford Centre for Evidence-based Medicine.
O Consenso em síndrome das pernas inquietas contou com a participação de neurologistas de vários estados brasileiros, os quais incansavelmente revisaram a literatura dos últimos anos em busca de evidências, tanto no que se refere ao diagnóstico como ao tratamento, de acordo com a Classificação do Centro de Oxford para Medicina Baseada em Evidências.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Kidney Calculi/surgery , Nephrostomy, Percutaneous/methods , Feasibility Studies , India , Nephrostomy, Percutaneous/adverse effects , Retrospective Studies , Treatment OutcomeABSTRACT
O autor avalia a prevalencia de epilepticos internados no Hospital Psiquiatrico Sao Pedro, caracteriza estsa populacao e sugere melhor abordagem do problema da epilepsia
