The glenoid-intramedullary humeral angle: a measurement of compensatory scapular abduction in advanced rotator cuff arthropathy and its potential effects on implant choice.

BACKGROUND: This study establishes measurements to evaluate pathologic compensation in rotator cuff tear arthropathy and resultant considerations for reverse shoulder arthroplasty. METHODS: Radiographs of patients with intact rotator cuffs were measured establishing interobserver and intraobserver reliability. Reverse shoulder arthroplasty cases performed by a single surgeon were then retrospectively reviewed. One year of follow-up radiographs were required for inclusion. Preoperative radiographs were analyzed for relative humeral head elevation ratio and humeral abduction relative to the glenoid face, termed the glenoid-intramedullary humeral angle. Statistical analyses assessed associations for radiographic measurements with presence and severity of scapular notching based on the Nerot-Sirveaux classification system. RESULTS: A total of 221 patients met inclusion criteria. At the 1-year follow-up, 61 (27.6%) shoulders had radiographic notching. There was a moderately strong (r = -0.56) negative correlation between glenoid-intramedullary humeral angle and humeral head elevation ratio. Patients with humeral head elevation ratio ≥ 20% were significantly (P = .024) and 9.2 times more likely to have notching of any grade. Patients with glenoid-intramedullary humeral angle ≤ 5 degrees were significant (P < .0001) and 6.7 times more likely to have notching of any grade and significantly (P = .00018) and 145 times more likely to have high-grade (3 and 4) notching. CONCLUSIONS: Preoperative humeral head elevation and compensatory scapular rotation with relative adduction of the humerus have significant associations with high-grade notching. These radiographic findings have potential to help surgeons in preoperative decision-making regarding implant choice and patient education.

Biochemistry of N-mustard tumour control compounds reconsidered.

The biochemicals and reactions involved in the present mechanism of degradation of tumour cells during chemotherapy are reconsidered and limitations noted. Alternative mechanisms and treatment methods are detailed.

Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications?

OBJECTIVES: To determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the likelihood of postoperative complications and fracture reoperation rate in orthopaedic trauma patients receiving vitamin D and calcium supplementation. DESIGN: Retrospective case series. SETTING: Level I trauma center, Midwestern United States. PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria. INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed. MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels. RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery. CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Effectiveness of Vitamin D Therapy in Orthopaedic Trauma Patients.

OBJECTIVE: The purpose of this study was to determine the effectiveness of our vitamin D treatment protocol in managing low serum vitamin D levels in orthopaedic trauma patients. METHODS: A retrospective review was conducted of all orthopaedic trauma patients at a university level I trauma center over 20 months. Patients were included if they had an initial and repeat 25-hydroxy (OH) vitamin D serum level available. Vitamin D deficiency was defined as serum 25-hydroxy vitamin D level with less than 20 ng/mL. Vitamin D insufficiency was defined as serum 25-hydroxy vitamin D level between 20 and 32 ng/mL. The standard regimen for all patients was over-the-counter vitamin D3 1000 IU and 1500 mg of calcium daily. Patients with vitamin D deficiency or insufficiency also received 50,000 IU of ergocalciferol (D2) weekly until their 25-hydroxyvitamin D level normalized or their fracture healed. No compliance monitoring was performed except for questioning at each clinic visit. RESULTS: A total of 201 patients met the inclusion criteria. Thirty-two patients had a normal initial 25-hydroxyvitamin D level, and 84% maintained their normal level, whereas 16% became insufficient or deficient. There were 88 patients insufficient initially and 54.5% improved to normal and 8% became deficient. In the vitamin D deficiency group (81), 26% remained deficient and 74% improved to insufficient. The average increase in serum 25-OH vitamin D with treatment (in nanograms per milliliter) was statistically significant for both the insufficient and deficient groups. CONCLUSIONS: Vitamin D therapy improved the majority of the patients' vitamin D-25-OH level but did not normalize most. Patients with initial deficiency had the largest improvement. This study indicates that vigilance is required to adequately treat a low serum vitamin D-25-OH level.