ABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Gitelman Syndrome/genetics , Mutation/genetics , Solute Carrier Family 12, Member 3/geneticsSubject(s)
Codon, Nonsense , Gitelman Syndrome/genetics , Adult , Gitelman Syndrome/blood , Humans , Male , Solute Carrier Family 12, Member 3/genetics , SpainABSTRACT
OBJECTIVE: To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt (TIPS) placement. CLINICAL PRESENTATION AND INTERVENTION: The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 months after TIPS placement, proteinuria was observed along with histological alterations characteristic of immune complex membranoproliferative glomerulonephritis (MPGN). CONCLUSION: The TIPS in one patient was successful without immediate complications, while the other patient was referred for a combined liver-kidney transplant. In both cases, immune complex MPGN might have developed after TIPS placement probably due to a reduced immune complex clearance.
Subject(s)
Glomerulonephritis, Membranoproliferative/etiology , Immune Complex Diseases/etiology , Liver Cirrhosis, Alcoholic/surgery , Portasystemic Shunt, Transjugular Intrahepatic/adverse effects , Antigen-Antibody Complex/immunology , Female , Glomerulonephritis, Membranoproliferative/immunology , Humans , Immune Complex Diseases/immunology , Male , Middle AgedABSTRACT
Levamisole is illicitly employed as a cocaine adulterant. The consumption of levamisole-adulterated cocaine can provoke anti-neutrophil cytoplasmic antibody (ANCA)-associated syndromes. Patients carrying an HLAB27 allele are known to be at higher risk of developing agranulocytosis when treated with levamisole. Likewise, patients with ANCA-associated vasculitis (AAV) and internal organ involvement have typically been exposed to offending agents for prolonged periods of time, often on the order of years. Here, we report an unusual case of a patient in which kidney biopsy showed membranous glomerulonephritis with cellular crescents associated with levamisole-contaminated cocaine use.
