Efficacy of Sphincter Control Training and medical device in the treatment of premature ejaculation: A multicenter randomized controlled clinical trial.

A new line of treatment for premature ejaculation (PE) based on the use of masturbation aid device in combination with behavioral techniques has emerged in recent years. We report a multicenter randomized clinical trial with a parallel group design to determine the effectiveness of an electronic device called Myhixel I© in the treatment of PE. Forty patients who met the criteria for the diagnosis of lifelong PE, were assigned to two treatment groups completed the Sphincter control training (SCT) program in eight weeks. The only difference between groups was the use of the device. The main measure was the "fold increase" (FI) of the intravaginal ejaculatory latency time (IELT). The geometric means of IELT show, at the end of the treatment at week 8, a superiority of the device group. The mean FI 4.27 (SD 2.59) at the end of treatment for the device group was clearly higher than obtained in the previous clinical trial, in which a specific medical device was not used. No side effects were observed and it required little therapeutic input and no partner involvement. The SCT program in combination with the Myhixel I© is an effective treatment for PE.

Efficacy of Sphincter Control Training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: A parallel-group randomized, controlled trial.

INTRODUCTION: Current evidence suggests that Cognitive Behavioral therapy (CBT) has a limited role in the contemporary management of premature ejaculation (PE). AIM: The aim of this study was to determine the efficacy of a new CBT for the PE called Sphincter Control Training (SCT) in combination with a masturbation aid device. METHODS: The present study included 35 patients' that met diagnostic criteria for PE including intravaginal ejaculatory latency time (IELT) of ≤2 minutes and had a Premature Ejaculation Diagnostic Tool (PEDT) score ≥11. Participants completed all phases of a randomized controlled clinical study with a parallel group design, which was approved by the Ethical Committee of the Hospital Morales Meseguer of Murcia (Spain).The two treatment groups completed SCT over 7 weeks. The SCT consists of four different exercises and an educational session. Its objective is to provide patients with greater knowledge, awareness, and control of the external urethral sphincter. The only difference between groups was the use of a masturbation aid device called Flip Zero (TFZ-001) from the Japanese company Tenga Co., Ltd. OUTCOMES: The main measure was the "fold increase" (FI) of the IELT, which was calculated using the geometric mean pre-treatment and post-treatment. In addition, Premature Ejaculation Profile PE was used as a secondary measure. RESULTS: The geometric mean of the measurements corresponding to the 7 weeks of treatment was calculated, and both groups were compared by means of an ANCOVA test, finding a statistically significant difference (F: 10.51, 1; p = .003) in the increase experienced by subjects in the group with the device (GWD) mean = 166.63, SD = 106.54) compared with that experienced by subjects in the group without device (GWtD) (mean = 86.99, SD = 59.98).Using Student's t-test, the Fold increase (FI) corresponding to both groups were compared. The results showed statistically significant differences (p = .008) between the measurements corresponding to the GWtD (1.38 (0.50)) and those relative to the GWD (2.69 (1.81)). CLINICAL IMPLICATIONS: The FI in the GWD at the end of the trial allow us to consider this new CBT as a potential and viable PE treatment alternative. No side effects were observed in either treatment group and it required little therapeutic input and no partner involvement. STRENGTHS & LIMITATIONS: The main limitation of this study is the lack of a 3- to 6-month follow-up of the treatment and placebo control. CONCLUSIONS: This SCT exercise program combined with the use of a masturbation device shows promise because has numerous advantages in relation to current recommended treatments in patients with PE.

Management of freezing rate and trehalose concentration to improve frozen dough properties and bread quality

Abstract Bread is one of the most consumed foods in the world, and alternatives have been sought to extend its shell life, and freezing is one of the most popular methods. The purpose of this study was to evaluate the effect of freezing rate and trehalose concentration on the fermentative and viscoelastic properties of dough and bread quality. Dough was prepared and trehalose was added at three concentrations (0, 400, 800 ppm); dough was pre fermented and frozen at two freezing rates then stored for 42 days. Frozen dough samples were thawed every two weeks. CO2 production and elastic and viscous modulus were determined. In addition, bread was elaborated and specific volume and firmness were evaluated. High trehalose concentrations (400 and 800 ppm) produced dough with the best viscoelastic and fermentative properties. Greater bread volume and less firmness were observed when a slow freezing rate (-.14 °C/min) was employed.

Leiomiosarcoma epiteloide gástrico. Presentación de un caso / Gastric epithelial leiomyosarcoma. A case review

Se presenta un caso de Leiomiosarcoma epiteloide gástrico de 10 cm de diámetro de la curvatura mayor del órgano en un hombre de 76 años de edad operado en nuestro centro al cual se le realizó gastrectomía subtotal y restitución de la continuidad gastrointestinal con gastroyeyunostomía tipo Billroth II. Teniendo en cuenta que este tipo histológico se observa solamente en el 2 porciento de los tumores gástricos con una supervivencia promedio a los 5 años del 50 porciento, se describen los hallazgos clínicos, anatomopatológicos y operatorios en este paciente con satisfactoria evolución postoperatoria. (AU)

Leiomiosarcoma epiteloide gástrico. Presentación de un caso / Gastric epithelial leiomyosarcoma. A case review

Se presenta un caso de Leiomiosarcoma epiteloide gástrico de 10 cm de diámetro de la curvatura mayor del órgano en un hombre de 76 años de edad operado en nuestro centro al cual se le realizó gastrectomía subtotal y restitución de la continuidad gastrointestinal con gastroyeyunostomía tipo Billroth II. Teniendo en cuenta que este tipo histológico se observa solamente en el 2 porciento de los tumores gástricos con una supervivencia promedio a los 5 años del 50 porciento, se describen los hallazgos clínicos, anatomopatológicos y operatorios en este paciente con satisfactoria evolución postoperatoria.

Flebitis Azul. Estudio preliminar / Blue Flebitis. Preliminary study

Se realizó un estudio a pacientes portadores de Flebitis Azul que estuvieron ingresados en los servicios de Angiología de los Hospitales Provinciales Docentes Antonio Luaces Iraola y Manuel Ascunse Doménech de Ciego de Avila y Camagüey respectivamente desde Enero de 1973 hasta Enero del 2003. Se analizaron los parámetros de edad, sexo, antecedentes patológicos personales, tratamiento utilizado y los logros obtenidos en el mismo. Se dan a conocer resultados preliminares de tener mayor frecuencia en el sexo masculino y en la quinta década de la vida. Los antecedentes patológicos personales más frecuentemente encontrados fueron las neoplasias y los mejores resultados se obtuvieron cuando se realizó tratamiento quirúrgico por Trombectomía. Se realizó además la revisión de la literatura respecto. (AU)

Flebitis Azul. Estudio preliminar / Blue Flebitis. Preliminary study

Se realizó un estudio a pacientes portadores de Flebitis Azul que estuvieron ingresados en los servicios de Angiología de los Hospitales Provinciales Docentes Antonio Luaces Iraola y Manuel Ascunse Doménech de Ciego de Avila y Camagüey respectivamente desde Enero de 1973 hasta Enero del 2003. Se analizaron los parámetros de edad, sexo, antecedentes patológicos personales, tratamiento utilizado y los logros obtenidos en el mismo. Se dan a conocer resultados preliminares de tener mayor frecuencia en el sexo masculino y en la quinta década de la vida. Los antecedentes patológicos personales más frecuentemente encontrados fueron las neoplasias y los mejores resultados se obtuvieron cuando se realizó tratamiento quirúrgico por Trombectomía. Se realizó además la revisión de la literatura respecto.