ABSTRACT
Mixed pancreatic epithelial and mesenchymal tumors are rare, usually invasive, entities. Intraductal papillary mucinous neoplasm (IPMN) is a precursor of invasive ductal carcinoma and shares mutations with its invasive counterparts. We report the case of a 72-year-old female with a previously undescribed sarcomatous transformation of a residual IPMN with no evidence of an invasive component. The mesenchymal component showed no heterologous differentiation. Both the epithelial and the mesenchymal populations showed aberrant expression of p53 protein and the same point mutation in KRAS gene. After a 6 month follow up, there were no signs of local or distant relapse. The present case suggests that sarcomatous transformation is possible in non-invasive, intraductal pancreatic lesions.(AU)
Las neoplasias pancreáticas mixtas son entidades raras que usualmente asocian comportamientos invasivos. La neoplasia papilar mucinosa intraductal (NPMI) es una lesión precursora del carcinoma invasivo que comparte con este último mutaciones clave. En el presente estudio se reporta por primera vez una transformación sarcomatosa sobre NPMI residual sin evidencia de componente infiltrante en una paciente de 72años. El componente mesenquimal no mostró diferenciación heteróloga. Tanto la población mesenquimal como la epitelial mostraron tinción aberrante para p53 y albergaban la misma mutación en el gen KRAS. Tras 6meses de seguimiento, la paciente no mostró signos de recaída local ni a distancia. El presente estudio demuestra que es posible una transformación sarcomatosa sobre NPMI.(AU)
Subject(s)
Humans , Female , Aged , Inpatients , Physical Examination , Pancreatic Intraductal Neoplasms , Pancreas/injuries , Pancreatic NeoplasmsABSTRACT
Mixed pancreatic epithelial and mesenchymal tumors are rare, usually invasive, entities. Intraductal papillary mucinous neoplasm (IPMN) is a precursor of invasive ductal carcinoma and shares mutations with its invasive counterparts. We report the case of a 72-year-old female with a previously undescribed sarcomatous transformation of a residual IPMN with no evidence of an invasive component. The mesenchymal component showed no heterologous differentiation. Both the epithelial and the mesenchymal populations showed aberrant expression of p53 protein and the same point mutation in KRAS gene. After a 6 month follow up, there were no signs of local or distant relapse. The present case suggests that sarcomatous transformation is possible in non-invasive, intraductal pancreatic lesions.
Subject(s)
Adenocarcinoma, Mucinous , Carcinoma, Pancreatic Ductal , Pancreatic Intraductal Neoplasms , Pancreatic Neoplasms , Female , Humans , Aged , Carcinoma, Pancreatic Ductal/pathology , Adenocarcinoma, Mucinous/genetics , Adenocarcinoma, Mucinous/pathology , Neoplasm Recurrence, Local , Pancreatic Neoplasms/pathologyABSTRACT
Introducción: La pandemia generada por la COVID-19 promovió que la superación profesional adquiriera nuevos matices. Las universidades fomentaron el uso de las tecnologías de la información y las comunicaciones, y el aprendizaje en los entornos virtuales. Objetivo: Exponer criterios sobre la virtualización de la superación profesional para el mejoramiento del desempeño pedagógico durante la COVID-19. Posicionamiento del autor: La situación generada por la COVID-19 exigió realizar el proceso de enseñanza aprendizaje en los entornos virtuales, por esta razón los profesores del Departamento de Ciencias Sociales asumieron este reto sin preparación previa. La superación profesional realizada en el Aula Virtual constituyó una vía eficaz para la aplicación de los recursos educativos virtuales. Conclusiones: La superación profesional en circunstancias sanitarias de emergencia se realizó en el Aula Virtual de la Escuela Latinoamericana de Medicina, donde se logró el mejoramiento del desempeño pedagógico de los docentes del Departamento de Ciencias Sociales(AU)
Introduction: The COVID-19 pandemic caused professional upgrading to acquire new shades. Universities encouraged the use of information and communication technologies, as well as learning in virtual settings. Objective: To present criteria on the virtualization of professional upgrading for the improvement of pedagogical performance during COVID-19. Author's stance: The situation caused by COVID-19 demanded to carry out the teaching-learning process in virtual settings; therefore, the professors from the social sciences area took up this challenge without previous preparation. The professional upgrading process carried out in the virtual classroom proved to be an effective way for the application of virtual educational resources. Conclusions: Professional upgrading during public health circumstances of emergency was carried out in the virtual classroom of the Latin American School of Medicine, where pedagogical performance could be improved among the professors from the social sciences area(AU)
Subject(s)
Humans , Teaching/education , Professional Training , Information Technology , COVID-19/prevention & control , LearningABSTRACT
INTRODUCTION: Macrophages containing exogenous pigments are commonly encountered in cytological specimens. CASE PRESENTATION: We present a case of tumor tattooing as an infrequent exogenous source of peritoneal fluid macrophagic pigment in a 76-year-old female. DISCUSSION AND CONCLUSION: Tattooing-derived ink can be a source of macrophagic pigment and should not be confused with other endogenous or exogenous pigments. The anatomical location and past medical history of the patient can aid in the diagnosis.
