Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms.

OBJECTIVE: To evaluate whether higher omega-6:omega-3 (n-6:n-3) long-chain polyunsaturated fatty acid ratio in cord plasma is associated with more symptoms of attention deficit and hyperactivity disorder (ADHD) at 4 and 7 years of age. STUDY DESIGN: This study was based on a population-based birth cohort in Spain. N-6 arachidonic acid and n-3 eicosapentaenoic and docosahexaenoic acid concentrations were measured in cord plasma. At 4 years old, ADHD symptoms were reported by teachers through the ADHD Diagnostic and Statistical Manual of Mental Disorders, 4th ed checklist (n = 580). At 7 years old, ADHD symptoms were reported by parents through the Conners' Rating Scale-Revised (short form; n = 642). The ADHD variable was treated as continuous (score) and as dichotomous (symptom diagnostic criteria). Child and family general characteristics were prospectively collected through questionnaires. We applied pooled zero-inflated negative binomial and logistic regressions adjusted for covariates. RESULTS: A higher omega-6:omega-3 long-chain polyunsaturated fatty acid ratio in cord plasma was associated with a higher ADHD index (incidence rate ratio, 1.13; 95% CI, 1.03, 1.23) at 7 years old. The association was not observed at 4 years old (incidence rate ratio, 1.04; 95% CI, 0.92-1.18). No associations were found using ADHD symptom diagnostic criteria. CONCLUSIONS: High prenatal omega-6:omega-3 long-chain polyunsaturated fatty acid ratio preceded the appearance of subclinical ADHD symptoms during mid-childhood. Our findings suggest that maternal diet during pregnancy may modulate the risk to develop long-term ADHD symptoms in the offspring.

The Association of Mediterranean Diet during Pregnancy with Longitudinal Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood.

OBJECTIVE: To evaluate the associations between maternal adherence to the Mediterranean diet during pregnancy and their offspring's longitudinal body mass index (BMI) trajectories and cardiometabolic risk in early childhood. STUDY DESIGN: We included mother-child pairs from the Infancia y Medio Ambiente (INMA) longitudinal cohort study in Spain. We measured dietary intake during pregnancy using a validated food frequency questionnaire and calculated the relative Mediterranean diet score (rMED). We estimated offspring's BMI z score trajectories from birth to age 4 years using latent class growth analyses (n = 2195 mother-child pairs). We measured blood pressure, waist circumference, and cardiometabolic biomarkers to construct a cardiometabolic risk score at 4 years (n = 697 mother-child pairs). We used multivariable adjusted linear and multinomial regression models. RESULTS: A higher maternal rMED in pregnancy was associated with a lower risk in offspring of larger birth size, followed by accelerated BMI gain (reference trajectory group: children with average birth size and subsequent slower BMI gain) (relative risk of high vs low rMED score, 0.68; 95% CI, 0.47-0.99). rMED score during pregnancy was not associated with the cardiometabolic risk score, its components, or related biomarkers. CONCLUSIONS: Higher adherence to the Mediterranean diet in pregnancy was associated with lower risk of having offspring with an accelerated growth pattern. This dietary pattern was not associated with the offspring's cardiometabolic risk at 4 years.

Estado nutricional e ingesta alimentaria de poblaciones de regiones de altura del Noroeste Argentino / Nutritional status and food intake of populations from high altitude regions of the Northwest of Argentina

El objetivo del trabajo fue estudiar el estado nutricional y la ingesta de alimentos de poblaciones andinas del Noroeste de Argentina. Se realizó una encuesta nutricional a una muestra representativa de las poblaciones de altura del noroeste de Argentina. Se tomó mediciones antropométricas, se registró la ingesta de alimentos a través de un recordatorio de 24h y un cuestionario de frecuencia de consumo. El retraso del crecimiento (talla para la edad según Z<-2 desviaciones estándares) fue el principal problema nutricional en los niños y adolescentes de la Puna y Quebrada. Mientras que el sobrepeso y la obesidad, evaluado a través de IMC > percentil 85 y 95 respectivamente, fueron los principales problemas nutricionales en los adolescentes de los Valles de altura. Las poblaciones adultas presentaron alta prevalencia de sobrepeso y obesidad, de acuerdo al IMC medio determinado. La composición típica del plato principal de toda la región tiene una base de arroz, pasta, harina de trigo o maíz que puede ser acompañada por tubérculos o huevos, o pocas hortalizas y carne de vaca o de llama. Este plato varía poco de un día para otro, constituyendo una dieta monótona, con alto consumo de azúcares (bebidas azucaradas y dulces) y cereales refinados. Estos resultados sugieren que estas poblaciones estarían en etapas tempranas de transición nutricional y podrían ser el punto de partida para fomentar consumos de alimentos más saludables y una dieta menos monótona. Sería recomendable reincorporar productos autóctonos de la región.

The purpose of this work was to study the nutritional status and food intake of Andean populations of Northwest of Argentine. A cross-sectional nutritional survey was carried out in representative samples of populations of highland from Argentine. Also anthropometric measurements, a food intake, a semi-quantitative food frequency questionnaire were performed and recorded. Stunting (height-for-age Z-score <-2 standard deviations) was the main nutritional problem in children and adolescents in the area of Puna and Quebrada regions. While overweight and obesity, evaluated by BMI> 85th and 95th percentile respectively, were the main nutritional problems among adolescents in the Valleys. Adult populations showed higher prevalence of overweight and obesity according to BMI determined. These are important risk factors for cardiovascular and chronic diseases.Usually the typical composition of the main food dish of regions has a base of rice, pasta, flour or corn, accompanied by tubers or eggs, or a few vegetables and beef. This dish varies little from one day to another, constituting a monotonous diet with a high intake of sugar (sugary drinks and sweets) and refined grains. Results suggest that these populations would be in early stages of nutritional transition and could be the starting point to promote them healthier food consumption and a diet less monotonous. It would be recommendable reincorporate native products of the region.

[Nutritional status and food intake of populations from high altitude regions of the Northwest of Argentia]. / Estado nutricional e ingesta alimentaria de poblaciones de regiones de altura del Noroeste Argentino.

The purpose of this work was to study the nutritional status and food intake of Andean populations of Northwest ofArgentine. A cross-sectional nutritional survey was carried out in representative samples of populations of highland from Argentine. Also anthropometric measurements, a food intake, a semi-quantitative food frequency questionnaire were performed and recorded. Stunting (height-for-age Z-score < -2 standard deviations) was the main nutritional problem in children and adolescents in the area of Puna and Quebrada regions. While overweight and obesity, evaluated by BMI> 85th and 95th percentile respectively, were the main nutritional problems among adolescents in the Valleys. Adult populations showed higher prevalence of overweight and obesity according to BMI determined. These are important risk factors for cardiovascular and chronic diseases.Usually the typical composition of the main food dish of regions has a base of rice, pasta, flour or corn, accompanied by tubers or eggs, or a few vegetables and beef. This dish varies little from one day to another, constituting a monotonous diet with a high intake of sugar (sugary drinks and sweets) and refined grains. Results suggest that these populations would be in early stages of nutritional transition and could be the starting point to promote them healthier food consumption and a diet less monotonous. It would be recommendable reincorporate native products of the region.

Nutritional status and dietary habits of the population of the Calchaqui Valleys of Tucuman, Argentina.

OBJECTIVE: To assess the nutritional status and dietary habits of the adult population of the Calchaqui Valleys of Tucuman. METHODS: A cross-sectional nutritional survey that included one 24-h recall, a semiquantitative food-frequency questionnaire, and anthropometric measurements was conducted in a representative sample of 113 adult participants. Pregnant and lactating women were excluded. Overweight and obesity were assessed according to body mass index, and the percentage of individuals with cardiovascular risk according to waist circumference and waist-to-hip circumference ratio was determined. Dietary habits were described according to the mean nutrient and food intakes of men and women. RESULTS: Means ± standard deviations for total energy intake of men and women were 1856 ± 859 and 1589 ± 799 kcal/d, respectively. The average body mass indices of men and women were 26.8 and 26.7 kg/m(2), respectively. Thirty-seven percent of the population was overweight and 22.8% was obese, whereas 1.8% of the population was undernourished. Central adiposity was high (mean waist circumferences 99.8 and 87.3 cm in men and women, respectively). CONCLUSIONS: Despite the low average energy intake, the population under study showed a high prevalence of overweight and obesity and a high risk of cardiovascular disease according to the central adiposity values. These findings could be explained by the introduction of new high-energy foods and a sedentary lifestyle or the possibility that the biological characteristics of these individuals make them more predisposed to a rapid increase in adiposity.