Year in Review 2023: Noteworthy Literature in Cardiac Anesthesiology.

Notable clinical research published in 2023 related to cardiac anesthesia included studies focused on resuscitation and pharmacology, regional anesthesia, technological advances, and novel gene therapies. We reviewed 241 articles to identify 25 noteworthy studies that represent the most significant research related to cardiac anesthesia from the past year. Overall, improvements in clinical practice have enabled decreased morbidity and mortality with a renewed focus on mechanical circulatory support and transplantation.

Year in Review 2022: Noteworthy Literature in Cardiac Anesthesiology.

Last year researchers made substantial progress in work relevant to the practice of cardiac anesthesiology. We reviewed 389 articles published in 2022 focused on topics related to clinical practice to identify 16 that will impact the current and future practice of cardiac anesthesiology. We identified 4 broad themes including risk prediction, postoperative outcomes, clinical practice, and technological advances. These articles are representative of the best work in our field in 2022.

Traumatic Suprahepatic inferior vena cava injury survival of a rare case.

Traumatic supra-hepatic inferior vena cava (IVC) injury is rare and nearly universally fatal. We report an excellent outcome from a case involving severe injury of the suprahepatic and intra-pericardial IVC utilizing emergency cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest. The goal of this case report is to outline key factors that facilitated the patient's survival of extensive IVC injury. We conclude that aggressive prehospital fluid resuscitation, facile transfer to the operating room, early detection of anatomy and pathology of the injury, an early decision to call for perfusion and cardiothoracic surgery, and prompt blood transfusion were the key factors that allowed for the patient to survive without deficits.

Stereoselective synthesis of tetrasubstituted olefins through a halogen-induced 1,2-silyl migration.

Migrating through Si valley: The highly stereoselective formation of α-silyl-ß- haloenones by way of silicon group migration is described. Electrophilic activation of the alkyne by N-halosuccinimides induced an anti-selective migration to give highly substituted enones (see scheme). These enone products can be readily converted to the all-carbon tetrasubstituted alkenes while maintaining their geometry.

Palladium-catalyzed Hiyama couplings of α-silylenoates and α-silylenamides.

The Hiyama couplings of both α-silylenoates and α-silylenamides are described. These sensitive substrate classes require particularly specific conditions, employing both appropriate silicon-based species and a silver additive to realize high yields of the coupling products. Regioselective platinum-catalyzed hydrosilylations provide a direct and convenient entry into these stereodefined trisubstituted alkenes.

Stereoselective syntheses of trisubstituted olefins via platinum catalysis: alpha-silylenones with geometrical complementarity.

The stereoselective syntheses of alpha-silylenones using catalytic PtCl(2) are reported. Via alkyne activation, alpha-hydroxypropargylsilanes are converted to (Z)-silylenones through a highly selective silicon migration. The complementary (E)-silylenones are accessed by a regioselective hydrosilylation of the ynone precursor. The synthetic utility of these compounds is demonstrated in cross-coupling reactions, highlighting the potential of these protocols for the syntheses of geometrically defined trisubstituted olefins.