ABSTRACT
OBJECTIVE: The purpose of this study was to determine the frequency of occult cerebral embolic events during carotid angiography and the relationship of these events to different phases of the procedure. SUBJECTS AND METHODS: Fifteen patients undergoing carotid angiography were prospectively evaluated by using continuous transcranial Doppler monitoring. Realtime visual and auditory confirmations of emboli were accomplished by recognizing their specific spectral signature and harmonic quality. Specific phases of the examination, such as manipulation of the catheter and guidewire, flushing of the catheter, and injecting contrast material were documented and correlated with embolic occurrences. RESULTS: A total of 1100 embolic phenomena were detected in the middle cerebral artery during carotid angiography. Of these, 944 occurred during catheter flushing and injection of contrast material, and 156 occurred during catheter and wire manipulation. In each patient, more emboli occurred during catheter flushing and injection of contrast material than during manipulation of the catheter and guidewire. No gross neurologic sequelae occurred. CONCLUSION: Embolic phenomena occur frequently during all phases of uncomplicated cerebral angiography.
Subject(s)
Angiography/adverse effects , Carotid Artery, Common/diagnostic imaging , Intracranial Embolism and Thrombosis/diagnostic imaging , Intracranial Embolism and Thrombosis/etiology , Ultrasonography, Doppler, Transcranial , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Cerebral CT performed in patients with Wilson disease (hepatolenticular degeneration) often reveals abnormalities of the putamen, globus pallidus, thalamocapsular region, cerebral cortex, dentate nucleus, and brain stem. We report a patient with Wilson disease who demonstrated rapid reversal of CT abnormalities following orthotopic liver transplantation.