[Directed therapy in complex treatment of lower limb diabetic angiopathy]. / Metody napravlennoi terapii v kompleksnom lechenii diabeticheskoi angiopatii nizhnikh konechnostei.

Clinical efficiency of directed therapy was assessed for 312 patients with distal type of lower limb diabetic angiopathy. Methods of directed therapy included indirect electrochemical detoxication, hemosorption and their combination. It was shown that while successful rate of conventional conservative therapy does not exceed 50%, hemosorption and indirect electrochemical detoxication can increase this rate by 5-35%, depending on the initial severity of lower limb ischemia. Directed therapy improves peripheral circulation and attenuates regional toxemia. Optimal results were achieved for combination of hemosorption and indirect electrochemical detoxication: treatment was effective for 87% of patients with 2-grade disease and for 73% - with 3-grade. One can speculate that synergic clinical effect may be attributed to functional normalization of antioxidant system. In conclusion, advantages of directed therapy comparing with conventional conservative treatment lie in its higher efficiency and prolonged therapeutic effect.

[Mechanism of action of paravasal infiltration]. / O mekhanizme deistviia paravazal'noi infiltratsii.

In order to study the mechanisms of action of paravasal infiltration the content of middle mass molecules and general thiol groups in the central and regional blood flow were studied in 65 patients with obliterating atherosclerosis. The relationship between the stage of extremity ischemia and concentration of general thiol groups was shown.

[Effectiveness of pathogenetic treatment of arterial obliterative diseases of the extremities]. / Vozmozhnosti patogeneticheskogo lecheniia obliteriruiushchikh zabolevanii arterii konechnostei.

The authors studied the activity of blood serum amine oxidase in patients with atherosclerosis obliterans and endarteritis obliterans. It was found that amine oxidase activity exceeded the normal value. 2.6 times in patients with stage 1-2 atherosclerosis obliterans and was reduced by more than 12 times in patients with stage 3-4 of the disease. The activity of the enzyme was absent in patients with endarteritis obliterans, whatever the stage of limb ischemia. On the basis of the obtained facts, the authors voice a new opinion on the nature of hypercatecholaminemia in obliterative diseases and suggest a new trend in the treatment of chronic ischemia of the limbs-activation of the processes of catabolism of vasoconstrictive biogenic amines.

[Serum amine oxidase activity and the methods of its correction in patients with arterial occlusive diseases of the extremities]. / Aktivnost' aminooksidazy syvorotki krovi i metody ee korrektsii u bol'nykh obliteriruiushchimi zabolevaniiami arterii konechnostei.

The article presents results of examination of blood serum ++amine oxidase++ in 78 patients with obliterating diseases of the extremity arteries. It was found that enzyme activity was dependent on the form and stage of the disease. The data obtained were used for the examination and medicamentous correction of the enzyme activity.