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1.
Clin Toxicol (Phila) ; 58(3): 178-182, 2020 03.
Article in English | MEDLINE | ID: mdl-31190571

ABSTRACT

Introduction: The majority of venomous snake exposures in the United States are due to snakes from the subfamily Crotalinae (pit vipers). There are three types of US pit vipers: rattlesnakes (Crotalus and Sisturus spp.) copperheads (Agkistrodon contortrix), and cottonmouths (Agkistrodon piscivorus) also known as water moccasins. Cottonmouth bites are reported less frequently than other pit viper envenomations, and data on cottonmouth envenomation are limited. Our objective was to describe the epidemiology, clinical manifestations, and management of cottonmouth envenomations using prospective data reported to the Toxicology Investigators Consortium's (ToxIC) North American Snakebite Registry (NASBR)Methods: Cottonmouth envenomation cases reported to NASBR for the period from January 1, 2013, through December 31, 2017 were reviewed. Variables collected included patient demographics, bite location, clinical manifestations, and management.Results: Thirty-one cottonmouth envenomations were reported. Most bites occurred in children aged 7-12 (39%). Most bites involved the lower extremity (72%). Intentional interaction with the snake occurred in three cases (10%). Swelling was the most reported clinical effect and occurred in all patients. Gastrointestinal symptoms were reported in 19% of patients, and 19% developed coagulopathy. Antivenom treatment was used in 84% of patients. Nineteen patients (61%) required hospital stays of >24 hours.Discussion: Our study represents the first systematic prospective data collection on cottonmouth bites. Our data demonstrate that cottonmouth envenomations cause primarily local effects and, occasionally, systemic toxicity. Our study also demonstrates that antivenom is often indicated for these envenomations per published guidelines and recommendations.Conclusions: Cottonmouth envenomations are relatively infrequent. However, they can cause significant local and systemic toxicity. Most cottonmouth envenomations in this series were treated with antivenom and were hospitalized beyond 24 hours.


Subject(s)
Agkistrodon , Registries , Snake Bites/epidemiology , Adolescent , Adult , Age Factors , Aged , Animals , Child , Child, Preschool , Female , Hospitalization/statistics & numerical data , Humans , Infant , Male , Middle Aged , North America/epidemiology , Registries/statistics & numerical data , Young Adult
3.
Clin Toxicol (Phila) ; 51(3): 147-50, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23473458

ABSTRACT

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is widespread, with a national (United States) prevalence of nearly 10%. The 2011 changes in the diagnostic criteria will likely further increase the prevalence of this disorder. Little is known about the incidence of toxicity from unintentional poisonings of ADHD medications. This study attempted to determine the incidence of these ingestions and the corresponding financial impact in the United States. METHODS: Four geographically different centers were chosen. Subjects with unintentional poisonings due to ADHD medications were included if the admission dates were between 2000 and 2002 (cohort A) or between 2009 and 2010 (cohort B). Using data from the participating hospitals and the number of monitored beds in each corresponding county, data were extrapolated on a national (United States) level. RESULTS: Sixty-three subjects were admitted at four hospitals (18, cohort A and 45, cohort B). The crude incidence rate ratio increased in the later time frame as compared to that in the earlier time frame (incidence rate ratio, 3.13; 95% CI, 1.80-5.68; p < 0.0001). The median (IQR) charges per patient, adjusted for inflation, were $4780 ($3,895-$8,287) and $5912 ($3,432-$9,433) for cohorts A and B, respectively (p = 0.57). If the subjects in the participating counties were only admitted to the participating hospitals, the annual charges, extrapolated throughout the United States for the two periods, would be $2,419,016 and $8,129,538, respectively. If the subjects were evenly distributed across all pediatric monitored beds in a given county, the annual charges extrapolated throughout the United States for the two periods would be $5,694,232 and $24,126,640, respectively. CONCLUSION: The incidence of unintentional poisonings from ADHD drugs is increasing and is associated with a significant cost.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Central Nervous System Stimulants/poisoning , Hospital Costs/statistics & numerical data , Hospitalization/economics , Attention Deficit Disorder with Hyperactivity/economics , Central Nervous System Stimulants/economics , Child , Child, Preschool , Drug Overdose/economics , Drug Overdose/epidemiology , Female , Hospitalization/statistics & numerical data , Humans , Male , United States/epidemiology
5.
Arch Intern Med ; 161(3): 474-9, 2001 Feb 12.
Article in English | MEDLINE | ID: mdl-11176775

ABSTRACT

Rattlesnake envenomations are common in some areas of the United States. Although fatal rattlesnake envenomations are rare and usually preventable, morbidity may be significant. Patients may present with localized edema, hypotension, coagulopathy, or thrombocytopenia. Patients with progressive swelling or severe coagulopathy are typically treated with Crotalidae polyvalent antivenin. We present a series of 4 patients with unusual complications of rattlesnake envenomation to illustrate the wide spectrum of disease that may be encountered. These case presentations include anaphylaxis to rattlesnake venom, an acute airway emergency, progressive and marked edema with a large pleural fluid collection, and death.


Subject(s)
Crotalus , Snake Bites , Adult , Airway Obstruction/etiology , Anaphylaxis/etiology , Animals , Disease Progression , Edema/etiology , Face , Fatal Outcome , Humans , Male , Middle Aged , Neck , Scrotum , Snake Bites/complications , Snake Bites/diagnosis
6.
J Emerg Med ; 20(1): 39-42, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11165836

ABSTRACT

A 40-year-old man with a history of schizophrenia and inflammatory soft tissue lesions after self-injection of elemental mercury presented to the Emergency Department. Multiple skin abscesses associated with fever required operative debridement. An incidental finding of oral mercury ingestion was followed clinically and did not result in complications. Exposure to elemental mercury through injection or ingestion is an uncommon event, but one the Emergency Physician may encounter. Subcutaneous mercury injection should be managed with local wound debridement, whereas ingestions are rarely of clinical significance.


Subject(s)
Mercury Poisoning/complications , Schizophrenia/complications , Soft Tissue Injuries/chemically induced , Abscess/chemically induced , Abscess/surgery , Administration, Oral , Adult , Debridement , Emergencies , Humans , Injections, Subcutaneous/adverse effects , Male , Radiography , Soft Tissue Injuries/diagnostic imaging , Soft Tissue Injuries/surgery , Suicide, Attempted
8.
Ann Emerg Med ; 36(6): 547-53, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11097693

ABSTRACT

STUDY OBJECTIVE: This study was conducted to determine whether hypertonic sodium bicarbonate would improve the hypotension associated with severe verapamil toxicity compared with volume expansion. METHODS: The study design used a nonblinded acute animal preparation. Twenty-four anesthetized and instrumented swine were poisoned with verapamil delivered at a rate of 1 mg/kg per hour for 10 minutes followed by incremental increases of 1 mg/kg per hour every 10 minutes until the endpoint of a mean arterial blood pressure of 45% of baseline was achieved. Animals alternately received either 4 mEq/kg of hypertonic sodium bicarbonate intravenously over 4 minutes or similar volumes of 0.6% sodium chloride in 10% mannitol (control). The main outcome parameter followed was mean arterial pressure. In addition, physiologic parameters including cardiac output, heart rate, pH, PCO (2), PO (2), plasma ionized calcium, sodium, and potassium were monitored. RESULTS: Verapamil toxicity, as defined by a mean arterial pressure of 45% of baseline, was produced in all animals following an average verapamil infusion dose of 0.6+/-0.12 mg/kg. This dose produced an average plasma verapamil concentration of 728.1+/-155.4 microgram/L, with no significant difference between groups. Swine treated with hypertonic sodium bicarbonate experienced a significant increase in mean arterial pressure (>50%) and cardiac output (>30%) over the first 20 minutes that slowly equilibrated with the control group over the remainder of the experiment. As expected, plasma sodium concentrations were elevated significantly in the sodium bicarbonate group while plasma potassium concentrations were decreased significantly. Finally, there was a significant decrease in plasma ionized calcium concentration in the sodium bicarbonate-treated group compared with controls. CONCLUSION: Hypertonic sodium bicarbonate reversed the hypotension and cardiac output depression of severe verapamil toxicity in a swine model.


Subject(s)
Drug-Related Side Effects and Adverse Reactions/drug therapy , Hypotension/drug therapy , Sodium Bicarbonate/pharmacology , Verapamil/toxicity , Animals , Blood Pressure Determination , Disease Models, Animal , Drug-Related Side Effects and Adverse Reactions/complications , Drug-Related Side Effects and Adverse Reactions/mortality , Hemodynamics/physiology , Hypertonic Solutions , Hypotension/etiology , Hypotension/mortality , Infusions, Intravenous , Male , Reference Values , Severity of Illness Index , Sodium Chloride/pharmacology , Survival Rate , Swine
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