Perfiles de los estados de ánimo, depresión, calidad de sueño, somnolencia y ansiedad del equipo de atletismo paralímpico: un estudio longitudinal / Profiles of mood states, depression, sleep quality, sleepiness, and anxiety of the Paralympic athletics team: A longitudinal study

Introducción: Conocer el perfil psicobiológico de un deporte de equipo es importante para definir el trabajo y también en la preparación para las competiciones. El objetivo de este trabajo fue elaborar un perfil psicobiológico del equipo de atletismo paralímpico durante un período de 7 meses. Material y métodos: Diecinueve atletas del atletismo brasileño fueron evaluados al final de la temporada, al comienzo de la temporada, y previamente a la competición. Las evaluaciones se realizaron mediante los cuestionarios siguientes: Perfil de estados de ánimo, Escala de depresión de Beck, Cuestionario de Pittsburg de calidad de sueño, Escala de somnolencia de Epworth e Inventario de la escala de ansiedad rasgo-estado. Resultados: La mayoría de los atletas mostraron un nivel de ansiedad rasgo-estado medio en el final y el comienzo de la temporada. Hubo diferencia entre: época previa a la competición y el final de la temporada, en el dominio de vigor, que se incrementó en el período precompetición; previa a la competición y el comienzo de la temporada en la duración total del sueño, con un aumento en la precompetición; el principio y el final de la temporada, en la latencia del sueño con una disminución en el comienzo de la temporada. Conclusiones: El período durante la temporada deportiva puede alterar las variables psicobiológicas, tales como bajo vigor, somnolencia diurna, y una mayor latencia de sueño al final de la temporada y la mala calidad del sueño al comienzo de la temporada. Por el contrario, la buena calidad del sueño y alto vigor en la etapa previa a la competición favorecen el rendimiento deportivo (AU)

Introduction: Determining the psychobiological profile of a team sport is important for defining The work to be performed in each phase, as well as in preparation for future competitions. The aim of this study was to draw a profile of mood states, depression, sleep quality, sleepiness and anxiety, of a Paralympic athletics team over a seven-month period. Materials and methods: An assessment was made of 19 athletes from the Brazilian athletics team at the end of season, beginning of season, and pre-competition. The assessments were performed using following questionnaires: profile of mood states, Beck Depression Inventory, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and the State-Trait Anxiety Inventory. The results were expressed as the mean and standard deviation, and the significance level was set at p < 0.05. Results: Most of the athletes exhibited a median level of trait-state anxiety at the end and at the beginning of the season. There was difference between: pre-competition and the end of season in the vigor domain, which was increased in the pre-competition; pre-competition and the beginning of the season in the total duration of sleep, with an increase in the pre- competition; the beginning and the end of the season, in sleep latency, with a decrease at the beginning of the season (AU)

Sleep influences the immune response and the rejection process alters sleep pattern: Evidence from a skin allograft model in mice.

INTRODUCTION: Sleep generally regulates immune functions in a supportive manner and can affect parameters that are directly involved in the rejection process. STUDY OBJECTIVES: The first objective was to assess whether sleep deprivation (SD) or sleep restriction (SR) affects the allograft rejection process in mice. The second objective was to investigate whether the rejection process itself modulates the sleep pattern of allografted mice. DESIGN: Adult BALB/c and C57BL/6J male mice were used as the donors and recipients, respectively, except for the syngeneic group (ISOTX), which received skin from mice of the same strain (C57BL/6J). The recipients were randomly assigned to either one of two control groups - TX (allogenic) or ISOTX (syngeneic) - which underwent stereotaxic surgery to enable sleep recording prior to the allograft but were not sleep deprived; one of two paradoxical sleep deprived groups - SDTX and TXSD - which underwent 72h of continuous SD either before or after the allograft respectively, and one of two sleep restricted groups - SRTX and TXSR - which underwent 21h of SD and 3h of sleep for 15days either before or after the allograft respectively. INTERVENTIONS: The skin allograft was inspected daily to determine the survival time, expected as 8.0±0.4days in this transplant model under no treatment. The sleep pattern was controlled throughout the rejection process in the SD and SR groups. Draining lymph nodes, spleen, blood and skin grafts were harvested on the 5th day after transplantation for evaluation of the immune parameters related to allograft rejection. MEASUREMENTS AND RESULTS: In the control groups, we observed a reduction in paradoxical sleep throughout the entire allograft rejection process. Acute and chronic experimental sleep loss in the SD and SR groups produced marked alterations in the immune response. Both SD and SR prolonged allograft survival compared to the non-sleep-deprived group. There were reductions in the following parameters involved in the allograft rejection under sleep loss: CD4+ and CD8+ T cell subpopulations in the peripheral lymph organs and spleen, circulating sIL-2R levels, graft-infiltrating CD4+ T cells and skin allograft global gene expression. CONCLUSIONS: We provide, as far as we are aware, the first evidence in vivo that the immune response can alter the normal sleep pattern, and that sleep loss can conversely affect the immune response related to graft rejection.

Sleep, Fatigue and Quality of Life: A Comparative Analysis among Night Shift Workers with and without Children.

INTRODUCTION: The reversal of the natural cycle of wakefulness and sleep may cause damage to the health of workers. However, there are few studies evaluating sleep, fatigue and quality of life of night shift workers considering the influence of small children on these variables. AIMS: Evaluate the sleep time, fatigue and quality of life of night shift workers and verify the relationship between these variables with the presence or absence of children in different age groups. METHODS: Were evaluated 78 mens shiftworkers, with or without children. Group 1, workers without children (G1-NC), group 2, workers with children pré-school age (G2-PS) and group 3, workers with children school age (G3-S). The sleep time (ST), sleep efficiency (SE), sleep latency (SL) and maximum time awake (MTA) were recorded by actigraphy. The risk of being fatigued at work was estimated by risk index for fatigue (RIF). RESULTS: The G1-NC showed a longer ST on working days and when evaluated only the first nights shift, after day off (p<0,005). This sample, the age of the children did not influence the sleep time these workers. The MTA on day off was lower in the workers from G2-PS. The RIF was lower on G1-NC in the first nights shift compared to the other groups. CONCLUSION: In this research, workers without children had higher sleep time during the working days. These workers also were less likely to feel fatigued during night work than workers with children, regardless of age these children.

Sleep quality and psychobiological aspects of brazilian paralympic athletes in the London 2012 pre-paralympics period / Qualidade de sono e aspectos psicobiológicos de atletas paralímpicos brasileiros no período pré-paralímpiadas de Londres 2012 / La calidad de sueño y los aspectos psicobiológicos de los atletas paralímpicos brasileños en el período pre-paralímpiadas de Londres 2012

The objective of the study was to evaluate the psychobiological aspects of the Paralympic athletes athletics mode, before the London Paralympic Games 2012. We evaluated 40 athletes without 31 men and 9 women who were selected by the Brazilian Paralympic Committee to be part of the Brazilian delegation. For the evaluation of psychobiological aspects used questionnaires: Trait Anxiety Inventory-State, POMS, the Beck Depression questionnaire Pittsburgh Epworth Scale to assess, respectively, anxiety, mood, depression, sleep and sleepiness. For trait anxiety and state anxiety, athletes exhibited a mean level of anxiety in relation to the profile of mood states and higher intensity values ​​than any other dimensions. The lower total sleep time was in athletes with bad sleep, sleep deficiency was lower in athletes with poor sleep and total sleep time was lower for those who had efficiency < 85%. All psychobiological variables evaluated in pre-competition period were normal for the athletes of the Brazilian Paralympic athletics team that took part in the London 2012 Paralympic Games.

O objetivo do estudo foi avaliar os aspectos psicobiológicos de atletas da modalidade de atletismo Paralímpico, antes dos Jogos Paralímpicos de Londres de 2012. Foram avaliados 40 atletas, sem 31 homens e 9 mulheres que foram convocados pelo Comitê Paralímpico Brasileiro para fazer parte da Delegação Brasileira. Para a avaliação dos aspectos psicobiológicos nós utilizamos os questionários: Inventário de Ansiedade Traço-Estado, POMS, Inventário de Depressão de Beck, questionário de Pittsburgh Escala de Epworth para avaliar, respectivamente, a ansiedade, o humor, a depressão, o sono e a sonolência. Para ansiedade-traço e ansiedade-estado os atletas apresentaram nível médio de ansiedade, em relação ao perfil dos estados de humor, a dimensão vigor apresentou valores mais altos do que as outras dimensões. O tempo total de sono foi menor em atletas com o sono ruim, a eficiência de sono foi menor em atletas com sono ruim e o tempo total de sono foi menor para quem teve eficiência < 85%. Todas as variáveis psicobiológicas avaliadas no período pré-competitivo estavam dentro da normalidade para os atletas da equipe Paralímpica Brasileira de atletismo que participaram dos Jogos Paralímpicos de Londres 2012.

El objetivo fue evaluar los aspectos psicobiológicos de los atletas de atletismo Paralímpico en el período que precedió los Juegos Paralímpicos de Londres de 2012. Se evaluaron 40 atletas. Los cuestionarios evaluaran la ansiedad, humor, depresión, sueño y la somnolencia. Para ansiedad-trazo y ansiedad-estado los atletas presentó nivel medio y no presentó propensión a la depresión. Los estados de humor la dimension vigor mostró un valor más alto. Para calidad de sueño los atletas presentó buen sueño, presentó somnolencia excesiva diurna y tuvo insatisfacción con el propio sueño. El tiempo total de sueño fue menor en atletas con un mal sueño, la eficiencia de sueño fue menor en atletas con un mal sueño y el tiempo total de sueño fue menor para quien tuvo eficiencia < 85%. Las variables psicobiológicas evaluados en el período previo a los Juegos Paralímpicos de Londres de 2012 eran normales para los atletas de la selección brasileña.

Immune outcomes of paradoxical sleep deprivation on cellular distribution in naive and lipopolysaccharide-stimulated mice.

BACKGROUND/AIMS: Several lines of evidence indicate that sleep loss imposes significant consequences on the host defense system, including changes in cell number, activity and distribution. However, it is not clear whether cellular alterations after sleep deprivation are caused by redistribution to immune organs or by death of these cells or how the response to a nonspecific immune activator would be affected. Therefore, the aim of this study was to assess the leukocyte distribution after paradoxical sleep deprivation (PSD) in saline- and lipopolysaccharide-treated mice. METHODS: Adult inbred mice were paradoxical sleep deprived (72 h), whereas the controls were kept in their home cages. After PSD, both groups received an injection of either saline or lipopolysaccharide (LPS; 1 or 5 µg/animal, intraperitoneally), 2 h prior to the collection of blood, spleen, lymph nodes and peritoneal wash. Isolated cells were then designated to differential leukocyte count (blood) and flow cytometry analysis of immune cell subsets (immune sites). RESULTS: The data revealed that PSD caused a significant reduction of circulating lymphocytes and a general decrease in all cellular subsets of spleen, mainly T and B cells. However, no alteration in response of PSD was found on other immune sites, such as lymph nodes and peritoneum. Of note, immune cell distribution in response to in vivo LPS stimulation remained unchanged after PSD. CONCLUSIONS: Our study provided original evidence concerning the immune outcomes of PSD, indicating that cellular decrease caused by PSD is not restricted to circulation, but also to immune sites. Taken together, our results could help shed light on the physiological mechanisms of leukocyte trafficking.