ABSTRACT
BACKGROUND: Digoxin poisonings are relatively common and potentially fatal, requiring immediate therapeutic intervention, with special attention to the patient's hemodynamic status and the presence of electrocardiographic and electrolytic disturbances. OBJECTIVE: To identify factors associated with seven-day and thirty-day mortality in digoxin poisoning. DESIGN, SETTINGS AND PARTICIPANTS: A retrospective, observational, multicenter study was conducted across 15 Hospital Emergency Departments (HED) in Spain. All patients over 18 years of age who presented to participating HEDs from 2015 to 2021 were included. The inclusion criteria encompassed individuals meeting the criteria for digoxin poisoning, whether acute or chronic. OUTCOMES MEASURE AND ANALYSIS: To identify independent factors associated with 7-day and 30-day mortality, a multivariate analysis was conducted. This analysis included variables of clinical significance, as well as those exhibiting a trend (p < 0.1) or significance in the bivariate analysis. MAIN FINDINGS: A total of 658 cases of digoxin poisoning were identified. Mortality rates were 4.5% (30 patients) at seven days and 11.1% (73 patients) at thirty days. Regarding 7-day mortality, the mean age of deceased patients was comparable to survivors (84.7 (8.9) vs 83.9 (7.9) years; p = ns). The multivariate analysis revealed that factors independently associated with 7-day mortality encompassed the extent of dependence assessed by the Barthel Index (BI 60-89 OR 0.28; 95% CI 0.10-0.77; p = 0.014 and BI>90 OR 0.22; 95% CI 0.08-0.63; p = 0.005), the identification of ventricular arrhythmias (OR 1.34; 95% CI 1.34-25.21; p = 0.019), and the presence of circulatory (OR 2.84; 95% CI 1.19-6.27; p = 0.019) and neurological manifestations (OR 2.67; 95% CI 1.13-6.27; p = 0.025). Factors independently associated with 30-day mortality encompassed extent of dependence (BI 60-89 OR 0.37; 95% CI 0.20-0.71; p = 0.003 and BI>90 OR 0.18; 95% CI 0.09-0.39; p < 0.001) and the identification of circulatory (OR 2.13; 95% CI 1.10-4.15; p = 0.025) and neurological manifestations (OR 2.39; 95% CI 1.25-3.89; p = 0.006). CONCLUSIONS: The study identifies the degree of dependency assessed by the Barthel Index and the presence of cardiovascular and neurological symptoms as independent predictors of both 7-day and 30-day mortality. Additionally, the detection of ventricular arrhythmia is also an independent factor for 7-day mortality.
Subject(s)
Digoxin , Humans , Female , Digoxin/poisoning , Digoxin/blood , Male , Retrospective Studies , Aged , Aged, 80 and over , Spain/epidemiology , Emergency Service, Hospital/statistics & numerical data , Risk Factors , Middle AgedABSTRACT
OBJECTIVES: To identify predictors for developing delayed neurological syndrome (DNS) after an initial episode of carbon monoxide (CO) poisoning in the interest of detecting patients most likely to develop DNS so that they can be followed. MATERIAL AND METHODS: Retrospective review of cases of CO poisoning treated in the past 10 years in the emergency departments of 4 hospitals in the AMICO study (Spanish acronym for the multicenter analysis of CO poisoning). We analyzed demographic characteristics of the patients and the clinical characteristics of the initial episode. The records of the cohort of patients with available follow-up information were reviewed to find cases of DNS. Data were analyzed by multivariant analysis to determine the relationship to characteristics of the initial exposure to CO. RESULTS: A total of 240 cases were identified. The median (interquartile range) age of the patients was 36.2 years (17.6-49.6 years); 108 patients (45.0%) were men, and the poisoning was accidental in 223 cases (92.9%). The median carboxyhemoglobin concentration on presentation was 12.7% (6.2%-18.7%). Follow-up details were available for 44 patients (18.3%). Eleven of those patients (25%) developed DNS. A low initial Glasgow Coma Scale score predicted the development of DNS with an odds ratio (OR) of 0.61 (95% CI, 0.41-0.92) and an area under the receiver operating characteristic curve of 0.876 (95% CI, 0.761-0.990) (P .001). CONCLUSION: The initial Glasgow Coma Scale score seems to be a clinical predictor of DNS after CO poisoning. We consider it important to establish follow-up protocols for patients with CO poisoning treated in hospital EDs.
OBJETIVO: Identificar factores pronósticos de desarrollo de síndrome neurológico tardío (SNT) después de un episodio inicial de intoxicación por monóxido de carbono (ICO), con el fin detectar precozmente a la población más susceptible y facilitar su acceso a un seguimiento específico. METODO: Revisión retrospectiva de todos los casos de ICO que acudieron a los servicios de urgencias (SU) de 4 hospitales durante los últimos 10 años. Se analizaron datos demográficos y características clínicas en el momento del episodio. En la cohorte de pacientes con datos de seguimiento disponibles, se evaluó la aparición de SNT y su relación con diferentes variables en la exposición inicial al CO a través de técnicas de análisis multivariante. RESULTADOS: Se identificaron 240 pacientes. La mediana de edad fue de 36,2 años (17,6-49,6). De ellos 108 (45,0%) eran hombres y 223 casos (92,9%) fueron accidentales. El nivel medio de COHb fue del 12,7% (6,2-18,7). En 44 (18,3%) episodios se disponía de datos de un seguimiento específico. En esta cohorte, 11 (25%) pacientes desarrollaron SNT. Una puntuación inicial más baja en la Escala Coma de Glasgow (GCS) (OR: 0,61, IC 95%: 0,41-0,92) fue predictor independiente del desarrollo del SNT, con un ABC en la curva COR de 0,876 (IC 95%: 0,761-0,990, p 0,001). CONCLUSIONES: Una puntuación inicial baja en la GCS parece ser un predictor clínico de desarrollo de SNT en la ICO. Dada la incidencia de SNT, consideramos fundamental establecer protocolos de seguimiento específico de estos pacientes tras su asistencia inicial en los SU.
Subject(s)
Carbon Monoxide Poisoning , Hyperbaric Oxygenation , Adult , Female , Humans , Male , Carbon Monoxide Poisoning/complications , Carbon Monoxide Poisoning/diagnosis , Carbon Monoxide Poisoning/therapy , Hyperbaric Oxygenation/methods , Retrospective Studies , Adolescent , Young Adult , Middle AgedABSTRACT
Objetivos. Identificar factores pronósticos de desarrollo de síndrome neurológico tardío (SNT) después de un episodio inicial de intoxicación por monóxido de carbono (ICO), con el fin detectar precozmente a la población más susceptible y facilitar su acceso a un seguimiento específico. Métodos. Revisión retrospectiva de todos los casos de ICO que acudieron a los servicios de urgencias (SU) de 4 hospitales durante los últimos 10 años. Se analizaron datos demográficos y características clínicas en el momento del episodio. En la cohorte de pacientes con datos de seguimiento disponibles, se evaluó la aparición de SNT y su relación con diferentes variables en la exposición inicial al CO a través de técnicas de análisis multivariante. Resultados. Se identificaron 240 pacientes. La mediana de edad fue de 36,2 años (17,6-49,6). De ellos 108 (45,0%) eran hombres y 223 casos (92,9%) fueron accidentales. El nivel medio de COHb fue del 12,7% (6,2-18,7). En 44 (18,3%) episodios se disponía de datos de un seguimiento específico. En esta cohorte, 11 (25%) pacientes desarrollaron SNT. Una puntuación inicial más baja en la Escala Coma de Glasgow (GCS) (OR: 0,61, IC 95%: 0,41-0,92) fue predictor independiente del desarrollo del SNT, con un ABC en la curva COR de 0,876 (IC 95%: 0,761-0,990, p < 0,001). Conclusiones. Una puntuación inicial baja en la GCS parece ser un predictor clínico de desarrollo de SNT en la ICO. Dada la incidencia de SNT, consideramos fundamental establecer protocolos de seguimiento específico de estos pacientes tras su asistencia inicial en los SU. (AU)
Objectives. To identify predictors for developing delayed neurological syndrome (DNS) after an initial episode of carbon monoxide (CO) poisoning in the interest of detecting patients most likely to develop DNS so that they can be followed. Methods. Retrospective review of cases of CO poisoning treated in the past 10 years in the emergency departments of 4 hospitals in the AMICO study (Spanish acronym for the multicenter analysis of CO poisoning). We analyzed demographic characteristics of the patients and the clinical characteristics of the initial episode. The records of the cohort of patients with available follow-up information were reviewed to find cases of DNS. Data were analyzed by multivariant analysis to determine the relationship to characteristics of the initial exposure to CO. Results. A total of 240 cases were identified. The median (interquartile range) age of the patients was 36.2 years (17.6-49.6 years); 108 patients (45.0%) were men, and the poisoning was accidental in 223 cases (92.9%). The median carboxyhemoglobin concentration on presentation was 12.7% (6.2%-18.7%). Follow-up details were available for 44 patients (18.3%). Eleven of those patients (25%) developed DNS. A low initial Glasgow Coma Scale score predicted the development of DNS with an odds ratio (OR) of 0.61 (95% CI, 0.41-0.92) and an area under the receiver operating characteristic curve of 0.876 (95% CI, 0.761-0.990) (P <.001). Conclusions. The initial Glasgow Coma Scale score seems to be a clinical predictor of DNS after CO poisoning. We consider it important to establish follow-up protocols for patients with CO poisoning treated in hospital EDs. (AU)
Subject(s)
Humans , Carbon Monoxide Poisoning , Neurotoxicity Syndromes , Carboxyhemoglobin , Prognosis , Emergency Medical Services , Poisoning/mortalityABSTRACT
BACKGROUND: Anorectal fistula, which is a relatively common pathology, is the chronic manifestation of the acute perirectal process that forms an anal abscess. The development of a fistula after incision and drainage of an anal abscess is seen in approximately 26-37%. Its treatment is a relevant topic, and the role of the use of antibiotic therapy in its prevention remains controversial, after the publication of several studies with contradictory results and several methodological limitations. Our hypothesis is that the combination of amoxicillin and clavulanic acid will reduce the incidence of anal fistula. METHOD: The aim of this study is to evaluate the efficacy of antibiotherapy after surgical drainage of perianal abscess in the development of perianal fistula. The PERIQxA study is a multicenter, randomized, double-blind controlled trial. The study has been designed to include 286 adult patients who will be randomly (1:1) assigned to either the experimental (amoxicillin/clavulanic acid 875/125 mg TDS for 7 days) or the control arm (placebo). The primary outcome measure is the percentage of patients that develop perianal fistula after surgery and during follow-up (6 months). DISCUSSION: This clinical trial is designed to evaluate the efficacy and safety of amoxicillin/clavulanic in the prevention of perianal fistula. The results of this study are expected to contribute to stablish the potential role of antibiotherapy in the therapeutics for anal abscess. TRIAL REGISTRATION: EudraCT Number: 2021-003376-14. Registered on November 26, 2021.
Subject(s)
Anus Diseases , Rectal Fistula , Skin Diseases , Adult , Humans , Abscess/diagnosis , Abscess/etiology , Abscess/prevention & control , Amoxicillin-Potassium Clavulanate Combination/adverse effects , Anus Diseases/complications , Anus Diseases/prevention & control , Anus Diseases/surgery , Rectal Fistula/diagnosis , Rectal Fistula/etiology , Rectal Fistula/prevention & control , Drainage/adverse effects , Drainage/methods , Treatment Outcome , Randomized Controlled Trials as Topic , Multicenter Studies as TopicABSTRACT
BACKGROUND: Body dysmorphic disorder (BDD) is defined as excessive concern with mild or nonexistent defects in personal physical appearance, which are not perceived by others. The worldwide prevalence of BDD ranges between 0.5% and 3.2%, with no differences across genders. The mean age of onset of BDD is 16.9 years. BDD is typically associated with young age, psychiatric disorders, and dermatological procedures. Patients with BDD typically display poorer mental health status than patients diagnosed with other mental disorders. OBJECTIVE: The aim of this study was to estimate the prevalence of BDD in Spain and to identify the variables associated with BDD. METHODS: We performed a cross-sectional descriptive study by collecting data through an anonymous web-based survey targeting the Spanish population aged 18 years or older. The measures in this study were (1) sociodemographic variables, (2) variables associated with dermatological and psychiatric disorders and cosmetic procedures, (3) scales measuring quality of life (12-item Short Form health survey, version 2) and (4) BDD (BDD Questionnaire). Statistical analysis was performed with SPSS software version 21. P values less than .05 were considered significant. RESULTS: Of the 2091 participants who took the survey, 322 (15.2%) met the criteria of having BDD. The mean age of the participants with BDD was 23.5 (SD 9.6) years. In terms of BDD prevalence, women accounted for 19.9% (284/1421), men accounted for 5.2% (34/653), and students accounted for 25.2% (263/1043). Approximately 46.6% (150/322) of the participants with BDD reported a history of psychiatric comorbidities, including anxiety disorders, depressive disorders, and eating disorders. BDD was significantly associated with female gender, younger age (18-24 years), students, monthly income of less than 500 (1=US $1.11), and the presence of dermatological and some psychiatric disorders such as depression, anxiety, and eating disorders (P<.05). The number of body parts of concern in participants with BDD was significantly higher than that in those without BDD (4.6 vs 2.2, respectively; P<.001). Regarding the body parts of concern, body fat was the most common concern for both groups with BDD and without BDD, followed by thighs, face, hips, and skin in the BDD group and thighs, teeth, and hair in the non-BDD group. Participants with BDD showed a significantly poorer self-perception of their mental health, irrespective of the presence of any mental disorder (P<.001). CONCLUSIONS: Our findings showed that the prevalence of BDD in Spain was higher than expected. Further, BDD is frequently associated with other psychiatric disorders, particularly depressive disorder, anxiety disorder, and eating disorder. Participants with BDD had a poorer perception of quality of life associated with mental but not physical health problems. Finally, the perception of quality of mental health life in participants with BDD was independent of diagnosis of any mental disorder.
ABSTRACT
INTRODUCCIÓN: El síndrome de Angelman es un trastorno del neurodesarrollo de origen genético, con importantes manifestaciones clínicas motoras, conductuales, comunicativas y electroencefalográficas, con especial relevancia en lo que concierne a la presencia de crisis epilépticas. OBJETIVOS: Describir las características electroencefalográficas (cualitativa y cuantitativamente) de los pacientes con diagnóstico de síndrome de Angelman y determinar el perfil electroencefalográfico según la edad y la alteración genética. PACIENTES Y MÉTODOS: Estudio observacional retrospectivo donde se analizaron las características demográficas, clínicas y electroencefalográficas de 51 pacientes con síndrome de Angelman. RESULTADOS: Se evidenció una mayor potencia delta en todas las regiones cerebrales, con un pico máximo en las regiones frontopolar y temporal, y una menor potencia en el rango de frecuencias alfa y beta en todas las regiones, con mayor preponderancia en los pacientes más jóvenes, con tendencia decreciente con la edad. La coherencia mostró un predominio delta y theta en la región frontopolar, que fue mayor para todas las frecuencias en el grupo de deleción, con predominio delta, especialmente en la región frontopolar. CONCLUSIÓN: El electroencefalograma podría ser un biomarcador útil como herramienta cualitativa y cuantitativa en la investigación del síndrome de Angelman y en la medición de la respuesta a eventuales terapias en investigación
INTRODUCTION: Angelman syndrome is a neurodevelopmental disorder of genetic origin, with important clinical motor, behavioural, communicative and electroencephalographic manifestations, with particular relevance as regards the presence of epileptic seizures. AIMS. To describe the electroencephalographic characteristics (qualitatively and quantitatively) of patients diagnosed with Angelman syndrome and to determine the electroencephalographic profile according to age and genetic alteration. PATIENTS AND METHODS: A retrospective observational study in which the demographic, clinical and electroencephalographic characteristics of 51 patients with Angelman syndrome were analysed. RESULTS: A higher delta power was evident in all brain regions, with a maximum peak in the frontopolar and temporal regions, and a lower power in the alpha and beta frequency range in all regions, with a greater preponderance in younger patients, and a trend that decreases with age. The coherence showed a predominance of delta and theta in the frontopolar region, which was higher for all frequencies in the deletion group, where delta was predominant, especially in the frontopolar region. CONCLUSION. The electroencephalogram could be a useful biomarker as a qualitative and quantitative tool in the investigation of Angelman syndrome and in measuring the response to possible therapies under investigation
Subject(s)
Humans , Male , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Female , Young Adult , Adult , Middle Aged , Angelman Syndrome/diagnostic imaging , Electroencephalography/methods , Neurodevelopmental Disorders/diagnostic imaging , Retrospective Studies , Biomarkers , Angelman Syndrome/physiopathologyABSTRACT
Objetivo: Diseñar y realizar una validación de aspecto y contenido de un cuestionario para medir la competencia notificadora de incidentes por medicamentos de los enfermeros hospitalarios. Método: Estudio descriptivo de validación de aspecto y contenido de un cuestionario. Se realizó una revisión de la literatura para la creación de ítems. Seis expertos valoraron la pertinencia de la inclusión de cada ítem en el cuestionario mediante el cálculo del índice de posición; se seleccionaron aquellos con índice de posición>0,70. El cuestionario fue pilotado por 59 enfermeros. Un grupo de expertos redujo la extensión del cuestionario pilotado mediante revisión, discusión y decisión por consenso de cada ítem. Resultados: Tras la revisión bibliográfica se elaboró una batería con 151 ítems agrupados en 3 dimensiones competenciales: actitudes, conocimientos y habilidades. El 52,9% (n=80) obtuvo un índice de posición>0,70. La tasa de respuesta en el estudio piloto fue del 40,65%. La mediana de tiempo para completar el cuestionario fue de 23:35 min. Tras la reducción por expertos, el cuestionario definitivo se conformó con 45 ítems agrupados en 32 preguntas. Conclusiones: El cuestionario NORMA diseñado para explorar la competencia en la notificación de incidentes por medicamentos por los profesionales de enfermería hospitalarios, presenta una adecuada validez de aspecto y contenido, además de fácil administración, lo que posibilita su implementación institucional (AU)
Aim: To design and perform a face and content validation of a questionnaire to measure the competence of hospital RN to report medication incidents. Methods: Content and face questionnaire validation descriptive study. A review of the literature was performed for the creation of ítems. A panel of six experts assessed the relevance of the inclusion of each ítem in the questionnaire by calculating the position index; ítems with position index >0.70 were selected. The questionnaire was piloted by 59 RN. Finally, a meeting was convened with experts, in order to reduce the length of the piloted questionnaire through review, discussion and decision by consensus on each item. Results: From the literature review, a battery of 151 ítems grouped into three elements of competence: attitudes, knowledge and skills was created. 52.9% (n=80) of the ítems received a position index > 0.70. The response rate in the pilot study was 40.65%. The median time to complete the questionnaire was 23:35minutes. After reduction by the experts, the final questionnaire comprised 45 ítems grouped into 32 questions. Conclusions: The NORMA questionnaire, designed to explore the competence of hospital RN to report medication incidents, has adequate face and content validity and is easy to administer, enabling its institutional implementation (AU)
Subject(s)
Humans , Drug-Related Side Effects and Adverse Reactions/nursing , Notification , Medication Errors/nursing , Inappropriate Prescribing/nursing , Nursing Staff, Hospital/statistics & numerical data , Health Knowledge, Attitudes, Practice , Professional Competence/statistics & numerical data , Psychometrics/instrumentation , Patient Safety/statistics & numerical dataABSTRACT
Background. The inappropriate use of antifungals is an important health problem related to increasing adverse effects, unnecessary cost and promotion of resistant and emerging fungal infections. Despite its relevance, many health institutions assign few resources to improve prescribing practices. Aims. To evaluate the efficiency of an antifungal stewardship programme (ASP) centered on restricted antifungal agents. Methods. The main activity during the eight-month study was to perform a programmed review of restricted antifungals (lipid formulations of amphotericin B, echinocandins and voriconazole) prescribed in hospitalized patients. In the case of amendable antifungal treatment, a recommendation was included in the electronic medical record. Results. A total of 280 antifungal prescriptions for 262 patients were revised during the study period. The indications were prophylactic in 85 cases (30.4%), pre-emptive in 10 cases (3.5%), empiric in 122 cases (43.6%), and directed in 63 cases (22.5%). A total of 70 prescriptions (25%) in 61 patients were considered to be amendable. In most of these cases, treatment could have been reduced considering the patient's clinical improvement and microbiological results. The most common advice was antifungals change (70%), antifungal withdrawal (21%), removal of one antifungal drug in cases of combined therapy (7%), and switching to oral route (1%). Proposed recommendations were addressed in 28 cases (40%). There was no significant difference in adherence with respect to the type of recommendation (p = 0.554). There was a 42% lower use of antifungals during the period of the study compared to that observed during a similar previous period. Mortality among patients who were treated according to the recommendations of the ASP was 17% and in whom treatment was not modified it was 30% (p = 0.393). Conclusions. ASPs centered on hospitalized patients may be an efficient strategy to ameliorate antifungal use in hospitals (AU)
Antecedentes. El uso inadecuado de los antifúngicos es un problema de salud relevante que puede incrementar los efectos adversos y generar costes innecesarios, además de favorecer la aparición de resistencias y de infecciones micóticas emergentes. A pesar de su importancia, muchas instituciones sanitarias destinan escasos recursos para mejorar las prácticas de prescripción. Objetivos. Evaluar la eficiencia de un programa de asesoramiento sobre antifúngicos basado en la prescripción de agentes antifúngicos restringidos. Métodos. La principal actividad durante el estudio de ocho meses de duración fue la realización de una revisión programada de antifúngicos restringidos, prescritos en los pacientes hospitalizados (formulaciones lipídicas de anfotericina B, equinocandinas y voriconazol). En el caso del tratamiento antifúngico modificable, se procedió a anotar una recomendación en la historia clínica electrónica. Resultados. Se revisó un total de 280 prescripciones de antifúngicos en 262 pacientes durante el período de estudio. Las indicaciones fueron de tipo profiláctico en 85 casos (30,4%), anticipado en 10 (3,5%), empírico en 122 (43,6%) y dirigido en 63 (22,5%). Se consideraron modificables un total de 70 prescripciones (25%) en 61 pacientes. En la mayoría de estos casos, el tratamiento podía reducirse teniendo en cuenta la mejoría clínica y los resultados microbiológicos del paciente. La indicación más frecuentemente realizada fue el cambio de antifúngico (70%), seguido por la retirada de dicho fármaco (21%), la eliminación de uno de los fármacos antifúngicos en casos de tratamiento combinado (7%) y, finalmente, la sustitución del tratamiento por la administración oral (1%). Las recomendaciones propuestas se aceptaron en 28 casos (40%). No se produjo una diferencia significativa en la adherencia con respecto al tipo de recomendación (p = 0,554). Durante el período de estudio se evidenció un descenso en el uso de antifúngicos del 42%, en comparación con el uso observado en un período previo similar. La mortalidad de los pacientes que fueron tratados de acuerdo con las recomendaciones fue del 17%, y del 30% en aquellos en los que no se modificó el tratamiento (p = 0,393). Conclusiones. El programa de asesoramiento sobre los antifúngicos prescritos en pacientes hospitalizados puede resultar una estrategia eficaz para mejorar el uso de estos fármacos (AU)
Subject(s)
Humans , Mycoses/drug therapy , Antifungal Agents/therapeutic use , Echinocandins/therapeutic use , Amphotericin B/therapeutic use , Drug Prescriptions/statistics & numerical data , Fluconazole/therapeutic use , Inappropriate Prescribing/statistics & numerical data , Drug Costs/statistics & numerical dataABSTRACT
This paper is a corrigendum to the previously published paper: "Antimicrobial stewardship in patients recently transferred to a ward from the ICU" [Rev Esp Quimioter. 2014 Mar;27(1):46-50.] This corrigendum was prepared in order to correct some erroneous comments included in the discussion section. First, it should be pointed out that there could have been several suitable options for treating many infections and that, therefore, the word "nadequate" was not the most appropriate in this situation. In addition, some comments about the interpretation of microbiological results made by ICU physicians have been removed from the first article because this variable was not included in the study. Finally, another change made to the discussion was to clarify the ICU physicians alleged low level of compliance with advice given by infectious disease specialists. This has been suggested in previous studies it cannot be substantiated when analyzing the results of the study. Purpose. Inappropriate use of antibiotics is an important health problem that is related to increasing bacterial resistance. Despite its relevance, many health institutions assign very limited resources to improving prescribing practices. An antimicrobial stewardship programme (APS) centred on patients discharged from the ICU could efficiently undertake this task. Methods. During this six month study the main activity was performing a programmed review of antimicrobial prescriptions in patients transferred to the ward from the ICU. In the case of amendable antimicrobial treatment, a recommendation was included in the medical record. Results. A total of 437 antimicrobial prescriptions for 286 patients were revised during a six month period and a total of 271 prescriptions (62%) in 183 patients were considered to be amendable. In most of these cases, treatment could have been reduced taking into consideration each patients clinical improvement and their location in a hospital area with a lower risk of infection due to resistant bacteria. The most common advice was antimicrobial withdrawal (64%), antimicrobial change (20%) and switching to oral route (12%). Proposed recommendations were addressed in 212 cases (78%). There was no significant difference in adherence with respect to the type of recommendation (p=0.417). There was a 5% lower use of antibiotics during the year the study was conducted compared to the previous one. Conclusions. ASPs centred on patients discharged from the ICU may be an efficient strategy to ameliorate antimicrobial use in hospitals
Este artículo es una corrección del artículo previamente publicado: "Antimicrobial stewardship in patients recently transferred to a ward from the ICU" [Rev Esp Quimioter. 2014 Mar;27(1):46-50.] Esta corrección ha sido elaborada para subsanar algunos comentarios erróneos incluidos en la discusión. Primero, hay que señalar que podría haber habido varias opciones adecuadas para el tratamiento de muchas infecciones y que, por tanto, la palabra "inadecuada" no era el más apropiada en esta situación. Además, algunos comentarios sobre la interpretación de los resultados microbiológicos realizados por médicos de la UCI se han eliminado del primer artículo porque esta variable no se incluyó en el estudio. Por último, otro cambio realizado en la discusión fue aclarar que los médicos de la UCI alegaron bajo nivel de cumplimiento con las recomendaciones dadas por los especialistas en enfermedades infecciosas. Esto ha sido sugerido en estudios previos y no puede ser demostrado en el análisis de los resultados de este estudio Objetivos. El uso inapropiado de antimicrobianos es un problema de salud relevante que se relaciona con aumento de la resistencia bacteriana y con el gasto farmacéutico innecesario. A pesar de su relevancia, un número elevado de instituciones sanitarias destinan escasos recursos para mejorar la prescripción antimicrobiana. Un programa de asesoramiento sobre el uso de antimicrobianos centrado en los pacientes dados de alta una unidad de cuidados intensivos (UCI) podría constituir una herramienta eficiente para mejorar este problema. Métodos. Durante este estudio de seis meses de duración se realizó una intervención consistente en una revisión programada, por expertos en enfermedades infecciosas, de las prescripciones antimicrobiana en pacientes trasladados a una sala de hospitalización desde UCI. En el caso de prescripción modificable se realizaba una recomendación en la historia electrónica. Resultados. Se revisaron de 437 prescripciones de antimicrobianos en 286 pacientes. En total, 271 prescripciones (62%) en 183 pacientes se consideraban modificables. En la mayoría de estos casos, el tratamiento podría ser ajustado a la baja teniendo en cuenta la mejoría clínica del paciente y su actual ubicación en un área hospitalaria con menos riesgo de infección por bacterias resistentes. El consejo más común fue retirada a los antimicrobianos (64%), el cambio a los antimicrobianos (20%) y la administración por vía oral (12%). Las recomendaciones propuestas fueron aceptadas en 212 casos (78 %). No hubo diferencia significativa en la adherencia a la recomendación por parte del clínico responsable ni con el tipo de recomendación (p = 0,417). Durante el año en que realizó el estudio se redujo la prescripción antibiótica en un 5% en comparación con el año anterior. Conclusiones. La revisión del tratamiento antimicrobiano en pacientes dados de alta de UCI puede ser una estrategia eficiente para mejorar el uso de estos fármacos (AU)
Subject(s)
Humans , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/therapeutic use , Infections/drug therapy , Medication Therapy Management/organization & administration , Continuity of Patient Care/organization & administration , Intensive Care Units/statistics & numerical data , Medication Errors/statistics & numerical data , Cost of IllnessABSTRACT
Purpose. Inappropriate use of antibiotics is an important health problem that is related to increasing bacterial resistance. Despite its relevance, many health institutions assign very limited resources to improving prescribing practices. An antimicrobial stewardship programme (APS) centred on patients discharged from the ICU could efficiently undertake this task. Methods. During this six month study the main activity was performing a programmed review of antimicrobial prescriptions in patients transferred to the ward from the ICU. In the case of inadequate antimicrobial treatment, a recommendation was included in the medical record. Results. A total of 437 antimicrobial prescriptions for 286 patients were revised during a six month period. In all, 271 prescriptions (62%) were considered inappropriate in 183 patients. The most common reasons for inappropriateness were treating unconfirmed infection (43%), inadequate antimicrobial coverage (34%) and intravenous administration when the oral route was feasible (11%). Proposed recommendations were addressed in 212 cases (78%). There was no significant difference in adherence with respect to the type of recommendation (p=0.417). There was a 5% lower use of antibiotics during the year the study was conducted compared to the previous one. Conclusions. ASPs centred on patients discharged from the ICU may be an efficient strategy to ameliorate antimicrobial use in hospitals (AU)
Objetivos. El uso inapropiado de antimicrobianos es un problema de salud relevante que se relaciona con aumento de la resistencia bacteriana y con el gasto farmacéutico innecesario. A pesar de su relevancia, un número elevado de instituciones sanitarias destinan escasos recursos para mejorar la prescripción antimicrobiana. Un programa de asesoramiento sobre el uso de antimicrobianos centrado en los pacientes dados de alta una unidad de cuidados intensivos (UCI) podría constituir una herramienta eficiente para mejorar este problema. Métodos. Durante este estudio de seis meses de duración se realizó una intervención consistente en una revisión programada, por expertos en enfermedades infecciosas, de las prescripciones antimicrobiana en pacientes trasladados a una sala de hospitalización desde UCI. En el caso de prescripción inadecuada se realizaba una recomendación en la historia electrónica. Resultados. Se revisaron de 437 prescripciones de antimicrobianos en 286 pacientes. En total, 271 prescripciones (62%) en 183 pacientes se consideran inapropiadas. Las razones más comunes identificadas fueron el tratamiento de infecciones no confirmadas clínicamente (43%), espectro antibacteriano inadecuado (34%) y el empleo de la vía intravenosa en casos que podían ser tratados por vía oral (11%). Las recomendaciones propuestas fueron aceptadas en 212 casos (78 %). No hubo diferencia significativa en la adherencia a la recomendación por parte del clínico responsable ni con el tipo de recomendación (p = 0,417). Durante el año en que realizó el estudio se redujo la prescripción antibiótica en un 5% en comparación con el año anterior. Conclusiones. La revisión del tratamiento antimicrobiano en pacientes dados de alta de UCI puede ser una estrategia eficiente para mejorar el uso de estos fármacos (AU)
Subject(s)
Humans , Anti-Bacterial Agents/therapeutic use , Medication Therapy Management/organization & administration , Drug Prescriptions/standards , Inappropriate Prescribing/prevention & control , Communicable Diseases/drug therapy , Continuity of Patient Care/organization & administration , Critical Care , Medication Errors/prevention & controlABSTRACT
Las Reacciones Adversas a Medicamentos (RAM) constituyen un problema de saludpública en nuestra sociedad. Se estima que en los países occidentales el 5,3%de los ingresos hospitalarios están asociados a RAM, el 6,7% de los pacienteshospitalizados sufre una RAM grave y que este problema supone el 5-9% del costeintrahospitalario. A pesar de que la notificación espontánea de sospecha deRAM a través de la tarjeta amarilla es el método más eficiente para la detecciónde reacciones adversas nuevas y/o serias a medicamentos, se estima que sólose notifican alrededor del 10%. La legislación española obliga a todos los profesionalessanitarios a notificar las sospechas de reacciones adversas a los medicamentosautorizados. Sin embargo, durante 2006, los enfermeros sólo aportaronel 3% de todas las Tarjetas Amarillas al Sistema Español de Farmacovigilancia. Lainfranotificación de RAM en los profesionales de Enfermería es un fenómeno pendientede estudio (AU)
Adverse reactions to drugs (ARD) are a public health problem in our society. It isestimated that in western countries, 5,3% of hospital admissions are associatedwith ARD, 6,7% of hospitalised patients suffer from severe ARD and that this problemaccounts for 5-9% of intrahospital cost. Despite the fact that spontaneousreporting of suspected ARD via the Yellow Card is the most efficient method forthe detection of new and/or severe adverse reactions to drugs, it is estimated thatonly about 10% are reported. Spanish legislation stipulates that all health care professionalsare mandatory reporters of suspected adverse reactions to authoriseddrugs. However, in 2006, nurses contributed only 3% of all Yellow Cards to theSpanish System of Drug Surveillance. The underreporting of ARD on the part ofnursing professionals is a phenomenon pending future study (AU)
Subject(s)
Humans , Disease Notification/statistics & numerical data , Disease Notification/legislation & jurisprudence , Medicamentous Disease/statistics & numerical data , SpainABSTRACT
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