ABSTRACT
We report a case of combined contact and photocontact allergic dermatitis to etofenamate in Flogoprofen gel (Chiesi Wasserman, Barcelona, Spain). Patch test results were positive at the nonirradiated site, but there was a stronger reaction at the irradiated site with etofenamate 0.05% in petrolatum (pet.) at d2 and d4. The use frequent of topical agents containing etofenamate and sun exposure can result in a predisposition to contact photoallergy. Clinical findings caused by etofenamate are uncommon. Allergic contact dermatitis is the most common cutaneous reaction reported. In American studies observed, no reactions were observed to etofenamate in subjects with photosensitivity because it was not included in the series of antigens used in testing.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Dermatitis, Allergic Contact/diagnosis , Flufenamic Acid/analogs & derivatives , Flufenamic Acid/adverse effects , Administration, Cutaneous , Aged , Ankle , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Arthralgia/drug therapy , Dermatitis, Allergic Contact/etiology , Dermatitis, Photoallergic/diagnosis , Dermatitis, Photoallergic/etiology , Diagnosis, Differential , Female , Flufenamic Acid/administration & dosage , Gels/administration & dosage , Gels/adverse effects , Humans , Patch TestsABSTRACT
Anetoderma is a rare elastolytic disorder included within the group of cutaneous atrophies. Its pathogenesis is not yet clearly established, but immunological mechanisms could play an important role in dermal elastolysis. It has been associated with different autoantibodies and autoimmune disorders. We present a case of anetoderma in a systemic lupus erythematosus patient with anti-proliferating-cell-nuclear-antigen and antiphospholipid antibodies, highlighting the peculiarities of such an association.
