ABSTRACT
Objetivo El objetivo de la presente revisión fue analizar y comparar la efectividad de distintos tipos de ejercicio terapéutico en personas con dolor crónico del raquis. Método La búsqueda de datos se realizó utilizando la base de datos electrónica MEDLINE. Se incluyeron ensayos clínicos aleatorizados, realizados en pacientes entre 18 y 65 años con dolor crónico en la región del raquis. Resultados Dos revisores independientes realizaron el análisis de la calidad metodológica utilizando la escala PEDro, siendo 13 los artículos finalmente seleccionados. Los diferentes tipos de ejercicio terapéutico tuvieron efectos significativos en la reducción del dolor, disminución de la discapacidad y mejora de la calidad de vida de los pacientes. Conclusiones Los resultados muestran que no hay una modalidad de ejercicio terapéutico superior a otras. La combinación de diferentes modalidades de ejercicio terapéutico podría resultar una herramienta completa para el manejo del dolor crónico en la columna (AU)
Objective The objective of the present review was to analyze and compare the effectiveness of different types of therapeutic exercise in people with chronic spinal pain. Methods Data search was conducted using the electronic database MEDLINE. Randomized clinical trials, conducted in patients between 18 and 65 years old with chronic pain in the spine region, were included. Results Two independent reviewers performed the analysis of methodological quality using the PEDro scale, with 13 studies finally selected. The different types of therapeutic exercise had significant effects on pain reduction, decrease of disability and improvement of the quality of life of the patients. Conclusions The results show that there is no modality of therapeutic exercise superior to others. The combination of different therapeutic exercise modalities could be a complete tool for the management of chronic pain in the spine (AU)
Subject(s)
Humans , Adolescent , Young Adult , Adult , Middle Aged , Aged , Exercise Therapy , Neck Pain/therapy , Chronic Pain/therapy , Quality of Life , Randomized Controlled Trials as TopicABSTRACT
OBJECTIVE: The objective of the present review was to analyze and compare the effectiveness of different types of therapeutic exercise in people with chronic spinal pain. METHODS: Data search was conducted using the electronic database MEDLINE. Randomized clinical trials, conducted in patients between 18 and 65 years old with chronic pain in the spine region, were included. RESULTS: Two independent reviewers performed the analysis of methodological quality using the PEDro scale, with 13 studies finally selected. The different types of therapeutic exercise had significant effects on pain reduction, decrease of disability and improvement of the quality of life of the patients. CONCLUSIONS: The results show that there is no modality of therapeutic exercise superior to others. The combination of different therapeutic exercise modalities could be a complete tool for the management of chronic pain in the spine.
Subject(s)
Chronic Pain , Low Back Pain , Adolescent , Adult , Aged , Chronic Pain/therapy , Exercise Therapy , Humans , Middle Aged , Quality of Life , Randomized Controlled Trials as Topic , Young AdultABSTRACT
Several works have shown the feasibility of engineering functional blood vessels in vivo using human endothelial cells (ECs). Going further, we explored the therapeutic potential of neovessels after gene-modifying the ECs for the secretion of a therapeutic protein. Given that these vessels are connected with the host vascular bed, we hypothesized that systemic release of the expressed protein is immediate. As a proof of principle, we used primary human ECs transduced with a lentiviral vector for the expression of a recombinant bispecific alphaCEA/alphaCD3 antibody. These ECs, along with mesenchymal stem cells as a source of mural cells, were embedded in Matrigel and subcutaneously implanted in nude mice. High antibody levels were detected in plasma for 1 month. Furthermore, the antibody exerted a therapeutic effect in mice bearing distant carcinoembryonic-antigen (CEA)-positive tumors after inoculation of human T cells. In summary, we show for the first time the therapeutic effect of a protein locally secreted by engineered human neovessels.