Serum immunoglobulin levels in schizoaffective disorders (manic and depressive).

Immunoglobulin levels (A, G, M) were measured with Mancini's radial immunodiffusion technique (RID). IgA and IgG levels showed a statistically significant increase in schizoaffective patients compared to normals, and schizophrenics, but no modification in comparison with the affective patients. IgM also showed a statistically significant increase which may constitute a trait marker for the schizoaffective disease.

Open clinical study of Clopixol-Acuphase (zuclopenthixol acetate) treatment followed by Clopixol Depot in acute psychoses with long-term course tendency.

The evolution of 28 patients displaying acute forms of psychoses (schizophrenia, mania, exacerbation of psychosis in chronic cases) was studied under the treatment with Acuphase Acetate continued with Clopixol Depot. In both therapies a tioxantenic neuroleptic is involved for the acute form of the illness (Acuphase) and for the maintenance treatment (Clopixol Depot). The assessment of the results was carried out on individual observation files using Global Rating Scale (G.R.S.), B.P.R.S. and paraclinical measurement to appreciate the biological tolerance. Favourable effects of treatment were evident in the first 4 days and in six cases even within the first 24 hours. The whole group of patients showed a significant decrease of morbidity evolving from a high severity to a medium and reduced one. The biological tolerance was very good, 6 to 12 months' care.

Assessment of various psychopharmacological combinations in the treatment of presenile and senile primary degenerative dementia.

The effects of various psychopharmacological combinations were used in a sample of 90 patient fulfilling the DMS-III criteria for presenile or senile primary degenerative dementia divided into 3 equal subgroups. Regardless of the drug combination used, an improvement of verbal test performances was noticed.