Evaluation of Airborne Asbestos Concentrations Associated with the Operation and Maintenance of Brakes and Clutches on Nonautomated Heavy Equipment.

This study evaluated the potential for chrysotile asbestos exposure during maintenance and operation of older, nonautomated heavy equipment with chrysotile-containing brake and clutch linings. Recent reports indicate that such equipment may be in current use in the U.S. and other locations, including developing countries, due to its lower cost and ease of maintenance compared to newer equipment. Personal and area airborne fiber concentrations were measured for cranes with draglines during brake and clutch repair, equipment operation, shop cleanup, and clothes handling of the mechanic's coveralls over a period of three days. The range of airborne chrysotile concentrations during the complete friction band replacement process, including band removal from the equipment, friction lining replacement, and reinstallation, ranged from 0.0053 to 0.0273 f/cc (phase contrast microscopy-equivalent or PCME) over 3.3 to 6.2 hours. Additional bench work tasks, including electric wire brushing, hand sanding, riveting, and compressed air use were also performed. Full shift airborne chrysotile concentrations (6.1-8.5 hours) for all combined maintenance activities were 0.0093, 0.0414, and 0.0445 f/cc (PCME), on days 1, 2, and 3, respectively. Personal short-term samples (14-36 minutes) for lining removal, installation, wire brushing, hand sanding, and compressed air use ranged from nondetect (ND) to 0.238 f/cc (PCME), below the U.S. Occupational Safety and Health Administration's (OSHA's) 30-minute excursion limit of 1 f/cc. Short-term samples during crane operation, shop cleanup, and simulated laundry activities with the mechanic's coveralls ranged from ND to 0.01 f/cc (PCME; 15-36 minutes). The results indicated that full-shift measured airborne chrysotile concentrations during the brake and clutch maintenance activities evaluated remained below the U.S. 8-hour time-weighted average (TWA) permissible exposure limit (PEL) for asbestos of 0.1 f/cc. The results are likely to be relevant to farmers, construction workers, and vehicle maintenance workers historically, as well as today for those who choose to continue using and maintaining such equipment.

Comparison of Hydration Index, Percent Hydration, and Trans-Epidermal Water Loss Measurements for Dermal Exposure and Risk Assessment.

Skin hydration and the barrier properties of the stratum corneum have been reported to be influential factors in the potential for retention of solid and semi-solid substances on the skin surface. The measurement of these characteristics of the skin, however, remains relatively uncommon in exposure assessments performed by industrial or occupational hygienists, even when the focus of the assessment is exposure to the skin. This study provides measurements of skin hydration using multiple instruments and multiple relevant skin site locations for comparative analysis. Three different measurement metrics, trans-epidermal water loss (TEWL), hydration index (HI), and percent hydration, were measured for 25 healthy volunteers at two different body locations for comparison: the center of the volar forearm, as previously recommended for interindividual comparison of hydration and barrier property measurements, and also the palmar tip of the index finger. The purpose of the comparative measurements was to allow for comparison between other published baseline volar forearm measurements and the palmar skin, which has not often been quantitatively assessed and reported in the literature, but is a relevant skin surface for sampling of the hands. This comparison will allow for consideration of the potential influence of palmar wipe sampling protocols on TEWL or skin hydration, and for the evaluation of the influence of skin hydration and TEWL on measured dermal transfer values. Collectively, the skin hydration levels and barrier properties at these two different measurement locations were found to be statistically significantly different, and as a result it is suggested that they be measured and recorded separately. Both measurement types and locations are likely to be important for the purposes of establishing skin hydration and health. Volar forearm measurements can also be important for understanding the underlying condition and barrier function of the skin, and palmar index finger measurements are necessary to understand the influence of both TEWL and skin hydration on quantitative dermal loading and transfer of solids and semi-volatile materials.

Influence of repeated contacts on the transfer of elemental metallic lead between compartments in an integrated conceptual model for dermal exposure assessment.

Transfer of contaminants to and from the skin surface has been postulated to occur through a number of different pathways and compartments including: object(s)-to-skin, skin-to-skin, skin-to-clothing, skin-to-gloves, air-to-skin, skin-to-lips, and skin-to-saliva. However, many identified transfer pathways have been only minimally examined to determine the potential for measurable transfer. The purpose of this study was to quantitatively evaluate repeated transfer between different compartments using elemental metallic lead (Pb) in the solid form using a series of systematic measurements in human subjects. The results demonstrated that some transfer pathways and compartments are significantly more important than others. Transfer of Pb could not be measured from skin to cotton clothing or skin to laminate countertop surfaces. However, transfer was consistently measured for skin-to-skin and between the skin and the surface of nitrile gloves, suggesting the potential for significant transfer to or from these compartments in real-world exposure scenarios, and the importance of these pathways. With repeated contacts, transfer increased non-linearly between 1 and 5 contacts, but appeared to approach a steady state distribution among the compartments within 10 contacts. Consistent with other studies, relative to 100% transfer for a single contact, the quantitative transfer efficiency decreased with repeated contacts to 29% after 5 contacts and 11-12% after 10 contacts; for skin-to-skin transfer measurements, transfer efficiency after either 5 or 10 contacts was approximately 50% of the single contact transfer. These data are likely to be useful for refining current approaches to modeling of repeated contacts for dermal exposure and risk assessment.

Measured removal rates of chrysotile asbestos fibers from air and comparison with theoretical estimates based on gravitational settling and dilution ventilation.

CONTEXT: Industrial hygiene assessments often focus on activity-based airborne asbestos concentration measurements, but few empirical data exist regarding the fiber removal rate from air after activities cease. OBJECTIVE: Grade 7T chrysotile indoor fiber settling (FS) rates were characterized using air sampling (NIOSH Method 7402). MATERIALS AND METHODS: Six replicate events were conducted in a 58 m(3) study chamber (ventilation 3.5 ACH), in which chrysotile-contaminated work clothing was manipulated for 15 min followed by 30 min of no activity. The fiber concentration decay constant and removal rate were characterized using an exponential decay model based on the measurements. RESULTS: Breathing zone airborne chrysotile concentrations decreased by 86% within 15-30 min after fiber disturbance, compared to concentrations during active disturbance (p < 0.05). Estimated mean time required for 99% of the phase contrast microscopy-equivalent (PCME) fibers to be removed from air was approximately 30 min (95% CI: 22-57 min). The observed effective FS velocity was 0.0034 m/s. This settling velocity was between 4.5-fold and 180-fold faster than predicted by two different particulate gravitational settling models. Additionally, PCME concentrations decreased approximately 2.5-fold faster than predicted due to air exchange alone (32 versus 79 min to 99% decrease in concentration). DISCUSSION: Other measurement studies have reported similar airborne fiber removal rates, supporting the finding that factors other than gravitational settling and dilution ventilation contribute measurably to PCM fiber removal from air (e.g. impaction, agglomeration). CONCLUSION: Overall, the scientific weight of evidence indicates that the time necessary for removal of 99% of fibers greater than 5 µm in length (with aspect ratios greater than 3:1) is approximately 20-80 min.

Evaluation of take-home exposure and risk associated with the handling of clothing contaminated with chrysotile asbestos.

The potential for para-occupational (or take-home) exposures from contaminated clothing has been recognized for the past 60 years. To better characterize the take-home asbestos exposure pathway, a study was performed to measure the relationship between airborne chrysotile concentrations in the workplace, the contamination of work clothing, and take-home exposures and risks. The study included air sampling during two activities: (1) contamination of work clothing by airborne chrysotile (i.e., loading the clothing), and (2) handling and shaking out of the clothes. The clothes were contaminated at three different target airborne chrysotile concentrations (0-0.1 fibers per cubic centimeter [f/cc], 1-2 f/cc, and 2-4 f/cc; two events each for 31-43 minutes; six events total). Arithmetic mean concentrations for the three target loading levels were 0.01 f/cc, 1.65 f/cc, and 2.84 f/cc (National Institute of Occupational Health and Safety [NIOSH] 7402). Following the loading events, six matched 30-minute clothes-handling and shake-out events were conducted, each including 15 minutes of active handling (15-minute means; 0.014-0.097 f/cc) and 15 additional minutes of no handling (30-minute means; 0.006-0.063 f/cc). Percentages of personal clothes-handling TWAs relative to clothes-loading TWAs were calculated for event pairs to characterize exposure potential during daily versus weekly clothes-handling activity. Airborne concentrations for the clothes handler were 0.2-1.4% (eight-hour TWA or daily ratio) and 0.03-0.27% (40-hour TWA or weekly ratio) of loading TWAs. Cumulative chrysotile doses for clothes handling at airborne concentrations tested were estimated to be consistent with lifetime cumulative chrysotile doses associated with ambient air exposure (range for take-home or ambient doses: 0.00044-0.105 f/cc year).

An analysis of workplace exposures to benzene over four decades at a petrochemical processing and manufacturing facility (1962-1999).

Benzene, a known carcinogen, can be generated as a by-product during the use of petroleum-based raw materials in chemical manufacturing. The aim of this study was to analyze a large data set of benzene air concentration measurements collected over nearly 40 years during routine employee exposure monitoring at a petrochemical manufacturing facility. The facility used ethane, propane, and natural gas as raw materials in the production of common commercial materials such as polyethylene, polypropylene, waxes, adhesives, alcohols, and aldehydes. In total, 3607 benzene air samples were collected at the facility from 1962 to 1999. Of these, in total 2359 long-term (>1 h) personal exposure samples for benzene were collected during routine operations at the facility between 1974 and 1999. These samples were analyzed by division, department, and job title to establish employee benzene exposures in different areas of the facility over time. Sampling data were also analyzed by key events over time, including changes in the occupational exposure limits (OELs) for benzene and key equipment process changes at the facility. Although mean benzene concentrations varied according to operation, in nearly all cases measured benzene quantities were below the OEL in place at the time for benzene (10 ppm for 1974-1986 and 1 ppm for 1987-1999). Decreases in mean benzene air concentrations were also found when data were evaluated according to 7- to 10-yr periods following key equipment process changes. Further, an evaluation of mortality rates for a retrospective employee cohort (n = 3938) demonstrated that the average personal benzene exposures at this facility (0.89 ppm for the period 1974-1986 and 0.125 ppm for the period 1987-1999) did not result in increased standardized mortality ratio (SMRs) for diseases or malignancies of the lymphatic system. The robust nature of this data set provides comprehensive exposure information that may be useful for assessing human benzene exposures at similar facilities. The data also provide a basis for comparable measured exposure levels and the potential for adverse health effects. These data may also prove beneficial for comparing relative exposure potential for production versus nonproduction operations and the relationship between area and personal breathing zone samples.