[The use of akatinol memantine in the residual phase of stroke].

Fifty patients who had had left-hemisphere stroke 1-12 months before the inclusion in the study were examined. All patients underwent the 90-day course of neurorehabilitation. Forty patients of the main group received akatinol memantine as an add-on drug during 90 days in the initial dosage 5-10 mg/day with the gradual increase to 20 mg/day (10 mg twice a day); the control group included 10 patients. Comparative efficacy of neurorehabilitation was assessed 1,5 and 3 months after treatment with clinical scales NIHSS and Barthel, testing of higher mental functions with 10-score original digital scale (V.M. Shklovsky et al), neurophysiological study (electroencephalography and constant brain potentials). The distinct effect of akatinol memantine on the restoration of higher mental functions and, to a less extent, on the movement deficit was seen. The dynamic neurophysiological study revealed that the addition of akatinol memantine to the neurorehabilitation course activates reserve possibilities of the left hemisphere in small or moderate poststroke lesions. The trend toward the association between the efficacy and the time since stroke onset and the intensity of rehabilitation measures was found.

[The possibilities of using himantane in the treatment of Parkinson's disease].

The domestic drug himantane has been used as a monotherapy in dosage 25 mg daily during 12 weeks in patients with Parkinson's disease. Patient's state has been assessed using clinical, electromyographic, electroneuromyographic, EEG and psychometric (UPDRS and other scales) methods. The preparation used is well tolerated, induces the significant decrease of movement disorders, i.e. tremor, and exerts a positive effect on emotional and personality disturbances. The clinical changes have been confirmed by electroneuromyographic data and EEG.

[Cholesterol-containing circulating immune complexes--a component of the blood serum in patients with ischemic heart disease that determines its atherogenic properties]. / Kholesterinsoderzhashchie tsirkuliruiushchie immunnye kompleksy-- komponent syvorotki krovi bo'lnykh ishemicheskoi bolez'niu serdtsa obuslovlivaiushchii ee aterogennos't.

In most patients with coronary heart disease (CHD) and angiographically documented stenosed 1-3 coronary arteries, serum contained cholesterol (C) in the circulating immune complexes (CIC), cholesterol levels in these complexes being directly related to serum atherogenicity, i.e. to their ability to cause a 2-5-fold accumulation of lipids in cultured smooth muscle cells (SMC) of the uninvolved human aortic intima (r = 0.91). Removal of IgG and IgM from the patients' sera led to a 75 and 37% decrease, respectively, in their atherogenic properties displayed in cultured SMC. Much more decrease in the atherogenic potential of the sera was seen in 2.5% polyethylene glycol-induced precipitation of CIC. At the same time, incubation of human aortic intimal SMC with CIC isolated from the atherogenic sera from CHD patients caused a 1.5-3-fold increase in intracellular C levels. It was suggested that CIC cholesterol was a determinant of atherogenicity of the sera from patients with coronary atherosclerosis.

[Cytotoxic action of the individual membrane components of Mycoplasma arthritidis and M. fermentans on rat lymphocytes]. / Tsitotoksicheskoe deistvie otdel'nykh komponentov membran Mycoplasma arthritidis i M. fermentans na limfotsity krys.

Study of the toxic properties of the preparations obtained from M. arthritidis has revealed that the cytotoxic activity of M. arthritidis is mainly linked with the cytoplasmic membrane and, partially, with the cytoplasmic fraction. The membrane substances of M. fermentans and the products of its vital activity are toxic with respect to target cells, the component translocated into the culture medium consisting of globular proteins. Interaction of the cytoplasmic membranes of these Mycoplasma species, as well as of the fractions of M. fermentans globular proteins, with rat lymphocytes is accompanied by a cytodestructive effect and an increased permeability for toxic dyes.

[Factors that control stem cell differentiation. II. The sensitivity of T-differentiated lymphocytes to the action of radiation and cytostatics]. / Faktory, kontroliruiushchie differentisirovku stvolovykh keltok. II. Chuvstvitel'nost' T-differentsiruiushchikh limfotsitov k deistviiu radiatsii i tsitostatikov.

Bone marrow stem cells of the parent genotype (CBA) produce mainly erythroid colonies in the spleen of lethally irradiated recipients (CBA-C57Bl)F1. T d-lymphocytes change this differentiation pattern from the mainly erythroid to the mainly myeloid pathway. The irradiation with 100 R does not abolish this effect. The lymphocytes irradiated in vitro with 200 R or more, and incubated with Mitomycin C or Cycloheximide lost the ability to change the differentiation pattern of the transplanted cells. T d-lymphocytes are radiosensitive cells that need DNA and protein synthesis for realizing their function.