Symptom recurrence and associated factors in postoperative patients with lumbar degenerative disease.

[Purpose] This study aimed to examine gradual changes in and relationships among preoperative and 3-month postoperative endpoints in patients with lumbar degenerative disease. [Participants and Methods] The study included 160 diagnosed with lumbar degenerative diseases who underwent surgery. Patients were divided into two groups: "good progress" and "recrudescence". Changes in the Japan Orthpedics Associations (JOA) score, JOA back pain evaluation questionnaire (JOABPEQ), and numeric rating scale (NRS) preoperatively and 3 months postoperatively, and their associations, were analyzed. [Results] Differences were found in preoperative NRS for low back pain, JOA score (other findings) at 3 months postoperatively, and NRS for low back pain at 3 months postoperatively. The causal analysis yielded paths for "daily life", "pain", and "social/psychological aspects", starting with "lumbar spine disorders". [Conclusion] The subjective symptoms, objective findings, lumbar spine dysfunction, gait dysfunction, and numbness at 3 months postoperatively yielded relevant information regarding the participants activities of daily living, pain, and social and psychological aspects, providing a perspective for monitoring postoperative patients.

Effects of lower leg muscle quality on gait variability in community-dwelling older and healthy young adults.

[Purpose] We aimed to determine whether lower leg muscle echo intensity, an indicator of muscle quality, is a useful predictor of gait variability after examining the relationship between physical activity and gait variability in community-dwelling older and healthy young adults. [Participants and Methods] This study comprised two tasks. In the first task, 18 older and 25 young adults were included as participants. We examined the relationship between the amount of physical activity and gait variability in both groups. In the second task, muscle echo intensity related to gait variability in each group was measured using ultrasound echoes after identifying common factors related to gait variability in 19 older and 19 younger adults, and trends were compared. [Results] In the first task, gait variability was significantly higher in the younger group than in the older group. A significant negative correlation was found between the amount of physical activity and gait variability in both groups. In the second task, multiple regression analysis was performed for gait variability, and lower leg muscle echo intensity was identified as a significant factor. There was no difference in the correlation coefficient between gait variability and lower leg muscle echo intensity between the two groups. [Conclusion] Lower leg muscle quality was one of the causes of gait variability, suggesting that it is a useful predictor of gait sway status.

The relationship between changes in deoxy Hb and body composition before and after cycling exercise during unilateral lower extremity occlusion.

[Purpose] To clarify the relationship between changes in deoxygenated hemoglobin level due to cycling exercise and body composition in healthy participants with unilateral lower-limb obstruction. [Participants and Methods] The height, weight, body mass index, and body composition (skeletal muscle mass, body water content, and body fat percentage) of nine healthy males were measured along with the anaerobic threshold. The protocol consisted of 7 minutes of rest followed by 4 minutes of cycling exercise (anaerobic threshold level) with unilateral lower extremity occlusion. After exercise, ischemia was released, and the participants was allowed rest for 5 minutes. Deoxygenated hemoglobin levels before and after the exercise and the relationship between the level of variation and each index were examined. [Results] Body water content and skeletal muscle mass showed a significant negative correlation with changes in deoxygenated hemoglobin level; however, no correlation was found for the other indices. Body water content and skeletal muscle mass were found to be significantly positively correlated. they showed a significant positive correlation with deoxygenated hemoglobin levels. [Conclusion] Our study indicates that body water content and skeletal muscle mass play a significant role in the recovery of blood flow following exercise.

Effects of horizontal console position on operator muscular stress during cardiac ultrasonic diagnosis.

Ultrasound examinations tend to put sonographers in unnatural postures, which may lead to musculoskeletal disorders. In order to address this issue, in this study, we focused on the horizontal position of the console of a diagnostic ultrasound system to quantitatively assess the influence of the work plane position on musculoskeletal stress cardiac ultrasonic diagnosis in the bed-sitting position. Five subjects were asked to simulate a scanning task that involved touching five points on the console, setting the work plane at different positions in the space. Electromyogram of each part of the body indicated that the least stressful position of the left hand was about 350 mm from the center of the trunk in the longitudinal (front-rear) direction and 100 mm left from the center of the trunk in the lateral (left-right) direction. It is necessary to rotate the console in front of the operator for this purpose.

Effects of horizontal console position on operator muscular stress during abdominal ultrasonic diagnosis.

Ultrasound examinations may require sonographers to adopt unnatural postures, which can lead to musculoskeletal disorders. We previously assessed the effect of a vertical operation panel on muscular stress. In this study, we focused on the horizontal positioning of the control panel of a diagnostic ultrasound system to quantitatively assess the influence of work plane position on musculoskeletal stress during scanning. Five subjects were asked to perform a simulated scanning task that involved touching five points on the control panel, with the work plane set at different positions in space. Electromyograms of each part of the body and wrist joint angles indicated that the least stressful position of the left hand was about 350 mm from the center of the trunk in the longitudinal (front-back) direction and 100 mm left of the center of the trunk in the lateral (right-left) direction.

Effects of a vertical console position on operator muscular stress during ultrasonic diagnosis.

Ultrasound examinations tend to put sonographers in unnatural postures, which may lead to musculoskeletal disorders. In this study, we focused on the height of the operation panel of the diagnostic ultrasound system to quantitatively assess the effects of panel height (work plane height) on musculoskeletal stress during scanning in a sitting position. Eight subjects were asked to perform a simulated scanning task that involved touching nine points on the operation panel at four different panel heights. Electromyogram, left wrist joint angle, and subjective evaluation on ease of manipulation, etc., indicated that the optimum height of the operation panel during scanning in a sitting position is elbow height.

ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain.

The ATBF1 gene encodes transcription factors containing four homeodomains and multiple zinc finger motifs. However, the gene products have yet to be identified and the role remains unknown in vivo. In this study, we raised an antiserum for ATBF1 and found high levels of expression of ATBF1 in developing rat brain. Western and Northern blot analyses detected a 400 kDa protein and 12.5 kb mRNA in developing rat brain, respectively; both corresponding to ATBF1-A but not the B isoform. The protein was highly expressed in the midbrain and diencephalon and mRNA was highly expressed in the brainstem, mostly in embryo and neonatal brain. Immunohistochemistry identified postmitotic neurons in the brainstem as the major site of ATBF1 expression, and the expression levels varied depending on age of and location in the brain. Expression was transient and weak in the precursor cells at early neurogenesis. ATBF1 decreased postnatally, but remained in mature neurons, including those expressing DOPA decarboxylase (DDC). High levels of ATBF1 were expressed in precursor cells in accordance with neurogenesis and were continued to the mature neurons in specific areas such as the inferior colliculus. Expression was not significant from precursor cells to mature neurons in the cerebral cortex and hippocampus. ATBF1 and its Drosophila homolog, Zfh-2, are known to regulate cell differentiation and proliferation via the interaction with either of the basic helix-loop-helix transcription factors, c-myb, or the DDC gene. Together with these reported functions the expression features detected here suggest that ATBF1 may participate in the regulation of neuronal cell maturation or region-specific central nervous system differentiation.