ABSTRACT
Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality. Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic. Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae.
Subject(s)
COVID-19/pathology , Aged , Autopsy , Biopsy, Large-Core Needle , Humans , Male , Middle AgedABSTRACT
INTRODUCCIÓN: existen datos controvertidos sobre la asociación entre la enfermedad celiaca (ECe) y la enfermedad inflamatoria intestinal (EII). OBJETIVO: estudiar la prevalencia de la ECe en pacientes recién diagnosticados de EII. MÉTODOS: estudio observacional retrospectivo con cribado de ECe en pacientes con diagnóstico reciente de EII mediante la determinación de anticuerpos antitransglutaminasa tisular (AATGt) y biopsia duodenal endoscópica. Ninguno de los pacientes había recibido corticoides, inmunosupresores o fármacos biológicos en los tres meses previos a la gastroscopia. En caso de presencia de Marsh 1, se excluyeron otras causas. Se diagnosticó ECe en pacientes con AATGt positivos, biopsia duodenal compatible y buena respuesta a dieta sin gluten. RESULTADOS: se realizó cribado de ECe en 163 pacientes. De ellos, seis tuvieron AATGt positivos (3,7% del total) y cuatro fueron diagnosticados de ECe (tres con colitis ulcerosa y uno con enfermedad de Crohn). Todos los pacientes con ECe y EII tenían niveles de IgA normales, AATGt positivos y marcadores genéticos de ECe. CONCLUSIONES: la prevalencia de ECe en nuestros pacientes con EII es mayor que la referida en otras series publicadas en la literatura de pacientes con EII. La combinación de AATGt y estudio genético de ECe en pacientes con EII permite el cribado de ECe en esta población
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Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Celiac Disease/complications , Celiac Disease/diagnosis , Inflammatory Bowel Diseases/complications , Inflammatory Bowel Diseases/diagnosis , Retrospective Studies , Risk Factors , PrevalenceABSTRACT
Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality. Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic. Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae
La enfermedad de coronavirus 2019 (COVID-19) ha afectado de forma mundial causando intensa morbimortalidad. Los hallazgos patológicos son claves para entender su patogénesis. A través de biopsias con aguja gruesa postmortem, intentamos responder a las incógnitas que giran en torno a la severidad de esta infección. Se enviaron muestras de cuatro pacientes COVID-19 positivos al servicio de Anatomía Patológica del Hospital Infanta Sofía (Madrid) en los meses de Abril y Mayo 2020. Se estudiaron a través de distintas técnicas y los resultados se compararon con la literatura, buscando similitudes y peculiaridades. Todos los pacientes tenían un diagnóstico de neumonía. Las biopsias mostraron daño pulmonar en la mayoría. El resto de los órganos estudiados fueron: corazón, hígado, bazo y riñón. Se encontraron características distintivas en muchos, las cuales fueron descritas exhaustivamente. En conclusión, el análisis microscópico de los órganos afectados por COVID-19 es importante para comprender ésta enfermedad y sus posibles consecuencias
Subject(s)
Humans , Male , Middle Aged , Aged , Coronavirus Infections/pathology , Severe Acute Respiratory Syndrome/pathology , Severe acute respiratory syndrome-related coronavirus/pathogenicity , Pneumonia, Viral/pathology , Pulmonary Alveoli/pathology , Biopsy, Large-Core Needle/methods , Polymerase Chain Reaction/statistics & numerical data , Histocytochemistry/methodsABSTRACT
INTRODUCTION: controversial data have been reported on the potential association between celiac disease (CeD) and inflammatory bowel disease (IBD). OBJECTIVE: to study the prevalence of CeD in patients newly diagnosed cases with IBD. METHODS: an observational, retrospective study was performed in patients with newly diagnosed IBD who were screened for CeD by anti-tissue transglutaminase antibodies (anti-tTG) measurements and an endoscopic duodenal biopsy. No patients had received corticosteroids, immunosuppressants or biologic drugs within the three months prior to gastroscopy. In the presence of Marsh 1, other causes were ruled out. CeD was diagnosed in patients positive for anti-tTG, compatible duodenal biopsy findings and a good response to a gluten-free diet. RESULTS: a total of 163 patients were screened for CeD. Of these, six (3.7%) were positive for anti-tTG and four were diagnosed with CeD (three had ulcerative colitis, one had Crohn's disease). All patients with both CeD and IBD had normal IgA levels, positive anti-tTG and CeD genetic markers. CONCLUSIONS: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD.
Subject(s)
Celiac Disease/epidemiology , Colitis, Ulcerative/complications , Crohn Disease/complications , Adolescent , Adult , Aged , Celiac Disease/diagnosis , Celiac Disease/immunology , Female , GTP-Binding Proteins/immunology , Humans , Immunoglobulin A/blood , Immunoglobulin G/blood , Male , Middle Aged , Prevalence , Protein Glutamine gamma Glutamyltransferase 2 , Retrospective Studies , Spain , Transglutaminases/immunology , Young AdultSubject(s)
Humans , Male , Aged , Leiomyoma/pathology , Rectal Neoplasms/pathology , Endoscopy, GastrointestinalABSTRACT
OBJETIVO: Aportación de un caso de metástasis peneana en un paciente con carcinoma rectal.MÉTODOS: Paciente de 70 años remitido a nuestra consulta por el hallazgo de induraciones en el pene habiéndose diagnosticado de carcinoma rectal 18 meses antes. Tras evaluación física es sometido a biopsia de dichas lesiones.RESULTADOS: El resultado del análisis anatomo-patológico de la biopsia de glande fue de metástasis de adenocarcinoma rectalCONCLUSIONES: Las metástasis en el pene son raras, y, habitualmente se producen en el contexto de enfermedad oncológica avanzada(AU)
OBJECTIVE: Contribution of a case of penile metastasis in a patient with metastatic rectal carcinoma.METHODS: A 70-Year-old patient was referred to our consultation after the discovery of penis indurations having been diagnosed of rectal carcinoma 18 months before. After physical examination penile biopsies were carried out.RESULTS: The pathological results of the Glans biopsy was rectal adenocarcinoma metastasis.CONCLUSIONS: Metastases in the penis are rare, and usually occur in the context of advanced oncological disease(AU)