ABSTRACT
A study was made of the vegetative parameters associated with the cardiac rhythm and central hemodynamics in 60 patients with myocardial infarction. In 45 patients the time course of the urinary excretion of catecholamines was examined. Regulation of cardiovascular system in patients with myocardial infarction in different time spells of the disease course was studied in relation to the particular features of the clinical picture and presence of complications.
Subject(s)
Autonomic Nervous System/physiopathology , Cardiovascular System/physiopathology , Myocardial Infarction/physiopathology , Adult , Cardiovascular System/innervation , Catecholamines/urine , Electrocardiography , Humans , Middle Aged , Myocardial Infarction/complications , Myocardial Infarction/urine , Time FactorsABSTRACT
The drug salvage developed by the authors was studied for its impact on maternal, fetal, neonatal homeostasis, the incidence of unfavourable outcomes in the mother and her fetus in 40 pregnant with cardiac malformations whose pregnancy was delivered via cesarean section as a planned operation. The baseline hypodynamic circulation was detected in pregnant with heart disease. This was found to be steady-state during the operation and the drug salvage was adequate in the females. This showed a 2.7- or 2.0-fold reduction in maternal cardiovascular events and unfavourable neonatal sequelae, respectively.
Subject(s)
Anesthesia, Intravenous/methods , Anesthesia, Obstetrical/methods , Cesarean Section , Mitral Valve Insufficiency/surgery , Mitral Valve Stenosis/surgery , Preanesthetic Medication/methods , Pregnancy Complications, Cardiovascular/surgery , Female , Fetal Monitoring , Humans , Intraoperative Care , Mitral Valve Insufficiency/physiopathology , Mitral Valve Stenosis/physiopathology , Pregnancy , Pregnancy Complications, Cardiovascular/physiopathologyABSTRACT
The object of the study was to determine the possibility of using myelopid in correction of the functional condition of the melatonin-opioid and the hypothalamo-hypophyseal-adrenal systems and of the activity of the neurohypophysis in traumatic toxicosis. It was demonstrated in rat experiments that in traumatic toxicosis myelopid modulates synthesis of neuropeptides (melatonin, corticoliberin) and their release into blood plasma. By reducing the blood plasma vasopressin content, myelopid promotes increase in the corticoliberin content in the hypothalamus and increase of 11-OCS biosynthesis in the adrenals. At the same time, the agent increases the melatonin content in the epiphysis cerebri of intact animals and in rats with traumatic toxicosis and reduces the content of leuenkephalin in blood plasma. The role of myelopid in correction of neuroendocrine disorders in traumatic toxicosis is discussed.
Subject(s)
Activins , Adjuvants, Immunologic/therapeutic use , Neurosecretory Systems/drug effects , Oligopeptides , Peptides/therapeutic use , Shock, Traumatic/drug therapy , Animals , Drug Evaluation, Preclinical , Hypothalamo-Hypophyseal System/drug effects , Hypothalamo-Hypophyseal System/physiopathology , Male , Melatonin/physiology , Neurosecretory Systems/physiopathology , Pituitary-Adrenal System/drug effects , Pituitary-Adrenal System/physiopathology , Rats , Receptors, Opioid/drug effects , Receptors, Opioid/physiology , Shock, Traumatic/physiopathologyABSTRACT
A study was made of the content of melatonin, cortisol and indicators of cellular (E-rosette formation, 3H-lymphocyte blast transformation) and humoral (E AC-rosette formation, IgA, IgM IgG) immunity in 36 children with acute viral neuroinfections (encephalitis, encephalomyelitis, chorio-ependymitis, polyradiculoneuritis). The children's age ranged from 7 to 14 years. A significant correlation was determined between the levels of melatonin, cortisol, 3H-lymphocyte blast transformation and IgG. Variants of immunomodulating therapy are provided, bearing in mind the disorders revealed.
Subject(s)
Immunoglobulins/analysis , Lymphocytes/immunology , Melatonin/blood , Nervous System Diseases/immunology , Virus Diseases/immunology , Acute Disease , Adjuvants, Immunologic/therapeutic use , Adolescent , Child , Humans , Hydrocortisone/blood , Immunity, Cellular , Lymphocyte Activation , Nervous System Diseases/blood , Nervous System Diseases/therapy , Rosette Formation , Virus Diseases/blood , Virus Diseases/therapyABSTRACT
Clinical investigation was performed and dopamine metabolism (renal catecholamine excretion) studied in 29 children and 5 adults with various forms of CP, 5 myasthenic children and 1 child with Strümpel disease treated with Nakom. The therapy was judged expedient in 20% of the cases of pronounced muscular rigidity and dystonia with decreased dopamine excretion. The drug proved ineffective in atonic, astatic, severe hyperkinetic arms, and in cases with severe psycho-organic signs.
Subject(s)
Carbidopa/therapeutic use , Cerebral Palsy/drug therapy , Dystonia Musculorum Deformans/drug therapy , Levodopa/therapeutic use , Myasthenia Gravis/drug therapy , Adolescent , Adult , Age Factors , Catecholamines/urine , Cerebral Palsy/urine , Child , Child, Preschool , Clinical Trials as Topic , Drug Combinations/therapeutic use , Dystonia Musculorum Deformans/urine , Humans , Muscle Rigidity/drug therapy , Muscle Rigidity/urine , Myasthenia Gravis/urineSubject(s)
Brain Diseases/etiology , Resuscitation , Toxemia/diagnosis , Adolescent , Adult , Autoantibodies/analysis , Brain Diseases/immunology , Brain Diseases/psychology , Coma/etiology , Coma/immunology , Coma/psychology , Emergencies , Humans , Immunity, Cellular , Neuropsychology , Polyamines/blood , Time Factors , Toxemia/etiology , Toxemia/immunology , Toxemia/psychologySubject(s)
Endorphins/physiology , Hypothalamo-Hypophyseal System/physiopathology , Pituitary-Adrenal System/physiopathology , Shock, Traumatic/physiopathology , Animals , Enkephalin, Leucine/pharmacology , Homeostasis/drug effects , Hypothalamo-Hypophyseal System/drug effects , Male , Naloxone/pharmacology , Pituitary-Adrenal System/drug effects , Rats , Receptors, Opioid/drug effects , Receptors, Opioid/physiologySubject(s)
Hypothalamo-Hypophyseal System/physiopathology , Pituitary-Adrenal System/physiopathology , Shock/physiopathology , 11-Hydroxycorticosteroids/metabolism , Adrenocorticotropic Hormone/metabolism , Corticotropin-Releasing Hormone/antagonists & inhibitors , Corticotropin-Releasing Hormone/metabolism , Corticotropin-Releasing Hormone/physiology , Humans , Shock/prevention & controlSubject(s)
Adaptation, Physiological , Adrenal Cortex Hormones/physiology , Catecholamines/physiology , Obstetric Labor Complications/physiopathology , Uterine Hemorrhage/physiopathology , Acute Disease , Female , Humans , Postpartum Period , Pregnancy , Pregnancy Trimester, Third , Shock, Hemorrhagic/physiopathologySubject(s)
Acid-Base Equilibrium , Adrenal Cortex/physiopathology , Adrenal Glands/physiopathology , Electrolytes/blood , Obstetric Labor Complications/physiopathology , Sympathetic Nervous System/physiopathology , Uterine Hemorrhage/physiopathology , Acute Disease , Adolescent , Adult , Female , Humans , Kidney/physiopathology , Pregnancy , Shock, Hemorrhagic/physiopathologyABSTRACT
The blood flow and absorption-excretory function of the liver were studied in 5 normal individuals and in 50 cases of mechanical jaundice. In 26 out of them mechanical jaundice was due to tumors localized in the hepatoduodenal zone, and in 24--mechanical jaundice was the complication of cholelithiasis. It was found that obstructive jaundice cases develop severe hepatocellular and hemodynamic disorders, the degree of which could be determined by the hall-absorption of ujoviridin, its clearance and relative percentage of the clearance.
