Alfabetización en salud mental en adolescentes españoles y su relación con las características sociodemográficas / Mental health literacy in spanish adolescents and its relationship with sociodemographic characteristics

Fundamentos: diferentes estudios identifican la alfabetización en salud y/o salud mental (asm) como factores protectores contra el desarrollo de un problema de salud mental. El objetivo de este trabajo fue determinar el grado de alfabetización en salud mental de la población adolescente de barcelona, así como su relación con variables sociodemográficas y educativas.métodos: se realizó un estudio transversal en barcelona durante el curso 2017-2018. Participaron 1.032 jóvenes entre trece y diecisiete años. Se recogieron las siguientes variables: sexo; edad; nacionalidad; nivel socioeconómico (rdhpc); y nota media escolar. La asm se midió mediante los test de conocimientos emhl (reconocimiento de problemas mentales y conocimientos en salud mental; rango 0-10 cada parte), estigma (cami: rango 10-50, y ribs: rango 4-20) y búsqueda de ayuda (ghsq: rango de 1 a 7). Se realizó análisis de regresión lineal múltiple ajustando el efecto de variables sociodemográficas sobre la puntuación de cada escala.resultados: la puntuación media (desviación típica) del emhl test fue de 7,28 (1,27) y 4,24 (1,14), respectivamente, obteniendo mayor pun-tuación las chicas, rdhpc altas, nota excelente y con nacionalidad española. La mayor diferencia de puntuación en emhl, ajustando por el resto de variables, correspondió a los adolescentes con nota media excelente y con índice rdhpc elevado (respecto a la categoría basal, beta=0,72 y 0,52, respectivamente). La puntuación media del estigma fue 27,6 (4,47) para cami y 8,83 (3,36) para ribs. Las variables relacionadas con una mayor diferencia de puntuación respecto a la categoría basal y ajustado por el resto de variables fueron: sexo (chico=1,54) y nota académica (excelente=-2,38) para cami, y nacionalidad (extranjera=0,82) y nota académica (excelente=-1,30) para ribs. La puntuación media de ribs fue 8,83 (3,36), siendo la mayor diferencia de puntuación respecto a la categoría basal la nacionalidad extranjera (beta=0,82) y tener una nota de excelente (1,30). La búsqueda de ayuda fue mayor en padres/madres y amigos, con diferencias según sexo y nacionalidad.conclusiones: el nivel de alfabetización de salud mental es medio-bajo. Mientras que género, nacionalidad y resultados académicos son los factores que se relacionan con conocimientos y estigma, el nivel socioeconómico se relaciona únicamente con conocimientos en salud mental.(AU)

Background: different studies identify mental health literacy as a protective factor for developing a mental health problem. The aim of this paper was to determine the degree of mental health literacy of the adolescent population of barcelona, and its relationship with socio-de-mographic and educational variables.methods: a cross-sectional study was carried out in barcelona during the 2017-2018 academic year. A total of 1,032 young people between thirteen and seventeen years of age participated. The following variables were collected: sex, age, nationality, socioeconomic status (rdhpc) and average school grade. The aim was to determine the degree of mental health literacy (knowledge, stigma and help-seeking) of the adolescent population of barcelona, and its relationship with socio-demographic and educational variables. Multiple linear regression analysis was performed adjusting for the effect of sociodemographic variables on the score of each scale.results: the mean score (standard deviation) of the emhl test was 7.28 (1.27) and 4.24 (1.14) respectively, with higher scores obtained by girls, high rdhpc, excellent score and spanish nationality. The greatest difference in emhl scores, adjusting for the rest of the variables, corresponded to adolescents with an excellent mean score and a high rdhpc index (with respect to the baseline category, beta=0.72 and 0.52 respectively). The mean stigma score was 27.6 (4.47) for cami and 8.83 (3.36) for ribs. The variables related to a greater difference in score with respect to the baseline category and adjusted for the rest of the variables were: gender (boy=1.54) and academic grade (excellent=-2.38) for cami, and nationality (foreign=0.82) and academic grade (excellent=-1.30) for ribs. The mean ribs score was 8.83 (3.36) with the largest difference in score from baseline being foreign nationality (beta=0.82) and having a grade of excellent (1.30). Help-seeking was higher in parents and friends, with differences according to gender and nationality.conclusions: the level of mental health literacy is medium-low. While gender, nationality and educational attainment are the factors that are related to knowledge and stigma, socio-economic status is only related to mental health literacy.(AU)

Prevalencia de la COVID persistente: seguimiento al año de una cohorte poblacional ambulatoria / Chronic COVID prevalence: one-year follow-up of an outpatient population cohort

Antecedentes y objetivo: la evolución a largo plazo en pacientes con COVID-19 no es suficientemente conocida. El objetivo es estimar la prevalencia de la COVID persistente (estado post-COVID-19) a los 6 y 12 meses en una cohorte poblacional.Material y métodos: estudio observacional, ambispectivo, realizado en un centro de Atención Primaria, incluyendo pacientes de 18-65 años con COVID-19 diagnosticado entre julio y diciembre de 2020. Se hicieron entrevistas telefónicas a los 6 y 12 meses, analizando la persistencia de síntomas, estado de salud e inicio de psicofármacos.Resultados: de 143 pacientes, 116 completaron el seguimiento (edad media: 43,6 años, 59% hombres). El 95,7% tuvieron infección leve, siendo el síntoma más frecuente la fatiga (69,8%). El número de síntomas disminuyó tras 6 (p <0,001) y 12 meses (p <0,001), mejorando la percepción de salud (p <0,001) y disminuyendo el tratamiento con psicofármacos (p = 0,04). Tenían estado post-COVID-19 el 41,4% (intervalo de confianza [IC] 95% 32,8-50,5) y el 8,6% (IC 95% 5,0-17,9) a los 6 y 12 meses, respectivamente. Conclusiones: casi todos los pacientes recuperaron su estado de salud a los 12 meses, con una prevalencia de estado post-COVID-19 inferior a la descrita.(AU)

Background and objective: long-term course in COVID-19 patients is not sufficiently known. The aim is to estimate the prevalence of post-COVID-19 condition at six and 12 months in a population cohort.Material and methods: observational, ambispective study, performed in a primary care centre, including patients aged 18-65 years with COVID-19 diagnosed between July-December 2020. Telephone interviews were conducted at six and 12 months, analyzing the persistence of symptoms, state of health and commencing psychotropic drugs.Results: of 143 patients, 116 completed follow-ups (mean age 43.6 years, 59% male). A total of 95.7% had mild infection, the most common symptom being fatigue (69.8%). The number of symptoms decreased after six (P<0.001) and 12 months (P<0.001), which improved the perception of health (P<0.001) and reducing treatment with psychoactive drugs (P=0.04). A total of 41.4% (95% CI 32.8-50.5) and 8.6% (95% CI 5.0-17.9) had post-COVID-19 condition at six and 12 months, respectively.Conclusions: almost all the patients recovered their health status at 12 months, with a prevalence of post-COVID-19 condition lower than that reported.(AU)

Fracturas de cadera en pacientes tratados con fármacos antipsicóticos. Estudio de cohortes históricas en Cataluña / Hip fractures in patients treated with antipsychotic drugs. Study of retrospective cohorts in Catalonia

Objetivo: Evaluar la incidencia de fractura de cadera en pacientes con tratamiento antipsicótico, comparándola con la de individuos que no han sido tratados con antipsicóticos.Diseño: Estudio de cohortes históricas de pacientes tratados con fármacos antipsicóticos (TAP) y pacientes sin tratamiento conocido (no TAP). El periodo de observación fue 2006-2014.Emplazamiento: Todos los equipos de atención primaria de Cataluña del Instituto Catalán de la Salud (ICS).Participantes: Pacientes mayores de 44 años con TAP de al menos 3 meses de duración. Cohorte control: selección aleatoria de pacientes no TAP emparejando por comorbilidades basales, sexo, edad y prescripción de fármacos (excluyendo psicofármacos). Se analiza un total de 22.010 pacientes.Mediciones principales Tasa de incidencia (×1.000 personas-año [PY]) de fractura de cadera en cada grupo (TAP y no TAP). Modelos de regresión de Cox para estimar riesgos ajustados (hazard ratio [HR]) añadiendo los psicofármacos como covariables. Resultados: La tasa de incidencia de fractura de cadera fue mayor en los pacientes TAP (5,83 frente a 3,58 fracturas por 1.000 PY), y es mayor en todos los estratos según sexo, edad y tipo de diagnóstico. El riesgo de sufrir una fractura de cadera fue un 60% mayor (HR: 1,60; IC95%: 1,34-1,92) en el grupo TAP que en el grupo no TAP. El riesgo fue mayor en el grupo con esquizofrenia (HR: 3,57; IC95%: 1,75-7,30), seguido del trastorno bipolar (HR: 2,61; IC95%: 1,39-4,92) y depresión (HR: 1,51; IC95%: 1,21-1,88). Conclusiones: Los pacientes con tratamiento antipsicótico presentan más riesgo de fractura de cadera que los que no han sido tratados con antipsicóticos.

ObjectiveTo evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it with that of individuals who have not been treated with antipsychotics.DesignRetrospective cohort study of patients treated with antipsychotic drugs (TAP) and patients without known treatment (non-TAP). The observation period was 2006–2014.SiteAll primary care teams in Catalonia of the Catalan Health Institute (ICS).ParticipantsPatients older than 44 years with TAP lasting at least 3 months. Control cohort: random selection of non-TAP patients matching for baseline comorbidities and other variables. A total of 22,010 are analyzed.Main measurements Incidence rate (1000× person-years: PY) of hip fracture in each group (TAP and non-TAP). Cox regression models to estimate adjusted risks (hazard ratio: HR).ResultsThe hip fracture incidence rate was higher in TAP patients (5.83 vs 3.58 fractures per 1000 PY), and is higher in all strata according to sex, age and type of diagnosis. The risk of suffering a hip fracture was 60% higher (HR: 1.60 95% CI: 1.34–1.92) in the TAP group than in the non-TAP group. The risk was higher in the group with schizophrenia (HR: 3.57 95% CI: 1.75–7.30), followed by bipolar disorder (HR: 2.61; 95% CI: 1.39–4.92) and depression (HR: 1.51; 95% CI: 1.21–1.88).ConclusionsPatients with antipsychotic treatment have a higher risk of hip fracture than those who have not been treated with antipsychotics.

[Hip fractures in patients treated with antipsychotic drugs. Study of retrospective cohorts in Catalonia]. / Fracturas de cadera en pacientes tratados con fármacos antipsicóticos. Estudio de cohortes históricas en Cataluña.

OBJECTIVE: To evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it with that of individuals who have not been treated with antipsychotics. DESIGN: Retrospective cohort study of patients treated with antipsychotic drugs (TAP) and patients without known treatment (non-TAP). The observation period was 2006-2014. SITE: All primary care teams in Catalonia of the Catalan Health Institute (ICS). PARTICIPANTS: Patients older than 44 years with TAP lasting at least 3 months. Control cohort: random selection of non-TAP patients matching for baseline comorbidities and other variables. A total of 22,010 are analyzed. Main measurements Incidence rate (1000× person-years: PY) of hip fracture in each group (TAP and non-TAP). Cox regression models to estimate adjusted risks (hazard ratio: HR). RESULTS: The hip fracture incidence rate was higher in TAP patients (5.83 vs 3.58 fractures per 1000 PY), and is higher in all strata according to sex, age and type of diagnosis. The risk of suffering a hip fracture was 60% higher (HR: 1.60 95% CI: 1.34-1.92) in the TAP group than in the non-TAP group. The risk was higher in the group with schizophrenia (HR: 3.57 95% CI: 1.75-7.30), followed by bipolar disorder (HR: 2.61; 95% CI: 1.39-4.92) and depression (HR: 1.51; 95% CI: 1.21-1.88). CONCLUSIONS: Patients with antipsychotic treatment have a higher risk of hip fracture than those who have not been treated with antipsychotics.

Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013-2018.

BACKGROUND: Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. The aim of this study was to assess the ratio of RV gastroenteritis (RVGE) admissions to all-cause hospitalizations in children under 5 years of age in areas with different VCR. METHODS: Observational, multicenter, cross-sectional, medical record-based study. All children admitted to the study hospitals with a RVGE confirmed diagnosis during a 5-year period were selected. The annual ratio of RVGE to the total number of all-cause hospitalizations in children < 5 years of age were calculated. The proportion of RVGE hospitalizations were compared in areas with low (< 30%), intermediate (31-59%) and high (> 60%) VCR. RESULTS: From June 2013 to May 2018, data from 1731 RVGE hospitalizations (16.47% of which were nosocomial) were collected from the 12 study hospitals. RVGE hospital admissions accounted for 2.82% (95 CI 2.72-3.00) and 43.84% (95% CI 40.53-47.21) of all-cause and Acute Gastroenteritis (AGE) hospitalizations in children under 5 years of age, respectively. The likelihood of hospitalization due to RVGE was 56% (IC95%, 51-61%) and 27% (IC95%, 18-35%) lower in areas with high and intermediate VCR, respectively, compared to the low VCR areas. CONCLUSIONS: RVGE hospitalization ratios are highly dependent on the RV VCR. Increasing VCR in areas with intermediate and low coverage rates would significantly reduce the severe burden of RVGE that requires hospital management in Spain. Clinical trial registration Not applicable.

Influencia de la diabetes mellitus en el tratamiento ortodóncico. Revisión de la literatura / Influence of diabetes mellitus in orthodontic treatment. A review of the literature

Introducción: Actualmente, un creciente número de pacientes con diabetes mellitus (DM) busca tratamiento ortodóncico, lo que hace necesario conocer las implicancias de la DM en dicho tratamiento. La presente revisión bibliográfica tiene como propósito evaluar la influencia de DM en el tratamiento ortodóncico. Revisión: Existen escasos estudios clínicos acerca del comportamiento de diabéticos ante fuerzas ortodóncicas, siendo realizados mayoritariamente en modelos animales. La DM altera la respuesta inmune, por tanto, la inflamación y síntesis de matriz extracelular. La fuerza ortodóncica produce desequilibrio entre las metaloproteinasas de la matriz extracelular y sus inhibidores, alterando la actividad fibroblástica. Este desequilibrio afecta más rápida y prolongadamente a diabéticos. La remodelación del colágeno en animales diabéticos causa retardo en la regeneración ósea, debilitamiento del ligamento periodontal (PL) y microangiopatías gingivales. Los altos niveles de citoquinas y quimioquinas pro-inflamatorias presentes en diabéticos amplifican la inflamación, lo que puede explicar el mayor número de osteoclastos en comparación con pacientes sin DM. En la DM, los osteoclastos actúan más prolongadamente tras fuerzas ortodóncicas, causando altos niveles de destrucción ósea y degradación del PL. La DM no controlada puede retardar el tratamiento ortodóncico, por lo que en este caso estaría contraindicado. Se ha observado que glicemias normales, transforman a diabéticos en sanos frente a fuerzas ortodóncicas, normalizando las respuestas periodontal y alveolar. Conclusiones: En animales, la DM ha mostrado aumento de destrucción del PL y hueso alveolar, y disminución de efectividad del movimiento ortodóncico. Para realizar un tratamiento ortodóncico, es fundamental que la DM esté controlada. (AU)

Introduction: An increasing number of patients with diabetes mellitus (DM) are now seeking orthodontic treatment. It is necessary to know the influence of DM on orthodontic treatment. This literature review aims to evaluate the influence of DM on orthodontic treatment. Review: There are few clinical studies on the behavior of diabetics under orthodontic forces, being performed on animal models. DM alters the immune response, thus inflammation and extracellular matrix synthesis. The orthodontic force produces an imbalance between extracellular matrix metalloproteinases and their inhibitors, altering the activity of fibroblasts. This imbalance affects diabetics faster and longer. Collagen remodeling in diabetic animals slows down bone regeneration, weakening of the periodontal ligament (PL) and gingival microangiopathies. High levels of cytokines and pro-inflammatory chemokines present in diabetics amplify inflammation, which may explain the greater number of osteoclasts relative to patients without DM. In DM, osteoclasts show longer action after orthodontic forces, causing high levels of bone destruction and LP degradation. Uncontrolled DM can delay orthodontic treatment, so in this case it would be contraindicated. It has been observed that normal glycemia transforms diabetics into healthy ones when faced with orthodontic forces, normalizing periodontal and alveolar responses. Conclusions: In animals, DM has shown increased destruction of PL and alveolar bone and decreased effectiveness of orthodontic movement. To perform orthodontic treatment, it is essential that the DM is controlled. (AU)

Neumomediastino secundario a fractura aislada de piso de órbita / Pneumomediastinum secondary to isolated fracture of orbit floorx

Resumen Introducción: El neumomediastino se define como la presencia de aire o gas dentro de los planos fasciales del mediastino. Por lo general, es un fenómeno secundario a perforaciones traumáticas del tracto aerodigestivo. El neumomediastino secundario a una fractura orbitaria es un evento raro. Se asocia a complicaciones potencialmente mortales como el neumotórax, el neumopericardio y la mediastinitis. Objetivo: Describir un caso de neumomediastino secundario a una fractura aislada de piso orbitario y su manejo médico-quirúrgico. Caso clínico: Paciente de sexo femenino de 42 años que sufre traumatismo en regiones facial, cervical y torácica desarrollando secundariamente un enfisema subcutáneo panfacial y un neumomediastino, el cual se resuelve exitosamente. Discusión: El neumomediastino secundario a una fractura aislada de piso orbitario es un evento muy raro. El aire puede descender a lo largo de los espacios fasciales hasta el mediastino. En este sentido, sonarse la nariz es un factor de riesgo para desarrollar esta pa-tología. Conclusión: Ocurrido un trauma maxilofacial puede presentarse enfisemas de espacios profundos de la cabeza, cuello e incluso el mediastino.

Introduction: Pneumomediastinum is defined as the presence of air or gas within the fascial planes of the mediastinum. It is usually a phenomenon secondary to traumatic perforations of the aerodigestive tract. Pneumomediastinum secondary to an orbital fracture is a rare event. And it is related to life-threatening complications such as pneumothorax, pneumopericardium and mediastinitis. Aim: To describe a case of pneumomediastinum secondary to an isolated orbital floor fracture and its medical-surgical management. Clinical case: A 42-year-old female patient who suffers trauma to the facial, cervical and thoracic regions, secondary development of a subcutaneous panfacial emphysema and pneumomediastinum, which resolves successfully. Discussion: Pneumomediastinum following an isolated orbital floor fracture is a very rare event. The air can descend along the fascial spaces to the mediastinum. In this sense, blowing your nose is a risk factor to develop this pathology. Conclusion: After a maxillofacial trauma, emphysema of the deep spaces of the head, neck and even the mediastinum can occur

Impacto de la pandemia COVID-19 en la atención de la diabetes mellitus según cobertura de salud en el Partido de General Pueyrredón, Argentina / Impact of the COVID-19 pandemic on diabetes mellitus care according to health coverage in the General Pueyrredón District, Argentina

INTRODUCCIÓN las personas con DM conforman un grupo de alto riesgo de enfermedad y muerte por COVID-19. Objetivos valorar el impacto de la pandemia COVID-19 en la atención de las personas con DM, focalizando en el control metabólico, internación y sus percepciones respecto del proceso de atención, en población con y sin cobertura de salud del PGP, Bs As, Argentina. MÉTODOS se apeló a la triangulación metodológica. El enfoque cuantitativo utilizó un diseño cuasi-experimental que comparó dos períodos de 12 meses de duración cada uno, delimitados por el 3 de marzo de 2020; el cualitativo recurrió a entrevistas en profundidad en base a ejes temáticos, se utilizó análisis temático. Se incluyeron personas de 18 años y más del PGP con diagnóstico de DM; se conformaron dos grupos según su situación de cobertura de salud. Los criterios de valoración principal fueron la HbA1c y el control metabólico; las diferencias con valor de p < 0,05 se consideraron estadísticamente significativas. Se ajustaron modelos multivariados. RESULTADOS se incluyeron 327 participantes [158 con cobertura de salud (48,3%), 169 sin cobertura (51,7%)]. La mediana de HbA1c aumentó de 8,1% (RIC 2,7) a 8,8% (RIC 2,8); los participantes sin cobertura de salud partieron de valores más altos en la prepandemia [Me 9.0 % (RIC 2,4) vs. Me 7,2 % (RIC 1,48)]. La pandemia, la falta de cobertura de salud y el tratamiento incompleto de la DM fueron predictores independientes del aumento de la HbA1c; el tratamiento con insulina fue predictor del deterioro del control glucémico. El trabajo doméstico y de enseñanza recayó en las mujeres. Angustia, estrés y tristeza fueron los sentimientos que caracterizaron la salud mental de las personas con DM en pandemia; el proceso de atención fue percibido con miedo e incertidumbre, acentuado en el grupo sin cobertura de salud. DISCUSIÓN la pandemia COVID-19 impactó en múltiples dimensiones de la vida de las personas con DM, resaltando diferenciales de género y clase.

Juvenile Xanthogranuloma: An Entity With a Wide Clinical Spectrum. / Xantogranuloma juvenil: una entidad con amplio espectro clínico.

Juvenile xanthogranulomas (JXGs) are rare, benign lesions that belong to the large group of non-Langerhans cell histiocytoses. JXG presents with 1 or more erythematous or yellowish nodules that are usually located on the head or neck. Most JXG lesions are congenital or appear during the first year of life. Extracutaneous involvement is rare, but the literature traditionally suggests investigating the possibility of ocular compromise. JXG is mainly a clinical diagnosis, but a skin biopsy may sometimes be needed for confirmation. JXGs on the skin are self-limiting and usually do not require treatment. This review describes the clinical and therapeutic aspects of JXG, emphasizing available evidence and the diagnosis of extracutaneous involvement.

Degradation of 2-mercaptobenzothizaole in microbial electrolysis cells: Intermediates, toxicity, and microbial communities.

The compound 2-mercaptobenzothizaole (MBT) has been frequently detected in wastewater and surface water and is a potential threat to both aquatic organisms and human health (its mutagenic potential has been demonstrated). This study investigated the degradation routes of MBT in the anode of a microbial electrolysis cell (MEC) and the involved microbial communities. The results indicated that graphene-modified anodes promoted the presence of more enriched, developed, and specific communities compared to bare anodes. Moreover, consecutive additions of the OH substituent to the benzene ring of MBT were only detected in the reactor equipped with the graphene-treated electrode. Both phenomena, together with the application of an external voltage, may be related to the larger reduction of biotoxicity observed in the MEC equipped with graphene-modified anodes (46.2 eqtox∙m-3 to 27.9 eqtox∙m-3).

[Image-guided brachyablation for hepatocarcinoma. Report of one case]. / Image-Guided BrachyAblation (IGBA) en hepatocarcinoma. Descripción de la técnica y reporte del primer caso en Chile.

Eighty percent of hepatocarcinomas are inoperable at the moment of diagnosis. Liver transplantation is the treatment of choice in these cases, but local therapies are another alternative. Among these, Image-Guided BrachyAblation is a safe choice. We report a 76-year-old male with a hepatocarcinoma, who was considered inoperable due to the high surgical risk of the patient. A local treatment with Image-Guided BrachyAblation was decided. A brachytherapy needle was placed in the tumor under computed tomography guidance and a 15 Gy single dose was delivered from an Iridium-192 source. The patient had no immediate complications and at one month of follow up he continued without incidents.

Interarm blood pressure measurement and the reference-arm assignment variability.

OBJECTIVE: The arm with the higher blood pressure (BP) is assigned as the follow up arm for hypertensive patients (reference-arm). We evaluated the reproducibility of this assignment. METHODS: BP was measured simultaneously on both arms with a double cuff validated device in two visits separated <10 days (two sets of three readings per visit). Two reference-arms were assigned in each visit (the arm with higher BP, at least ≥1 mmHg). The intravisit and intervisit agreements of this assignment were evaluated. RESULTS: We included 313 hypertensive patients. First visit mean right arm BP was 131.6 (16.6)/75.3 (9.4) mmHg and left arm BP was 132.4 (16.9)/75.7 (9.7) mmHg (P = 0.002). Intravisit concordance at the first and second visits were κ = 0.60 [95% confidence interval (CI), 0.516-0.696] and κ = 0.45 [95% CI, 0.356-0.555], respectively. Therefore, 21.8% of patients (at the first visit) and 29.1% (at the second visit) with the right arm as the reference-arm in the first round of readings changed to the left arm in the same visit in the second round of readings. The intervisit κ index was 0.25 [95% CI, 0.147-0.365]. After that, 36.8% of patients with the right arm as the reference-arm at the first visit changed to the left arm at the second visit. The subgroup (9.5%) with an interarm systolic BP difference ≥10 mmHg at the first visit did not differ significantly from the rest of patients. CONCLUSION: The reference-arm assignment agreement is weak to moderate. The assignment of the reference-arm should be individualized and not considered as definitive.

Proper pertussis vaccination will probably not increase vaccination coverage: a case-control study.

Vaccination coverage (VC) against pertussis can increase when management practices and policies at primary care centres (PCCs) are reinforced. From 2011 to 2015, we performed a case-control study to evaluate VC among pertussis patients treated at PCCs in Barcelona, Spain. We recorded pertussis in patients from 8- to 16-year-olds at 52 PCCs. Pertussis cases had laboratory diagnostic and controls were healthy outpatients visiting the same facility for reasons other than cough. DTaP/dTap VC was recorded as either proper vaccination status (five doses recorded) or improper vaccination status (<5 doses recorded). We used a logistic regression model to estimate OR and 95% CI. We included 229 cases and 576 controls. VC was higher in cases (mean 5.01, s.e.: 0.57) than in controls (4.89, s.e.: 0.73). Around 69% of the cases had received DTaP primary immunisation after 2-5 years and 31.4% of cases had the dTap booster immunisation after 7-10 years. The 87% of children 5-9 years were properly vaccinated. We found no protection from becoming ill among properly vaccinated children (OR 1.87; 95% CI 1.22-2.85). The highest VC was observed in patients with confirmed pertussis, which was likely due to a more exhaustive follow-up of the VC in these patients. Being properly vaccinated against pertussis will probably not increase VC.

Image-Guided BrachyAblation (IGBA) en hepatocarcinoma: descripción de la técnica y reporte del primer caso en Chile / Image-guided brachyablation for hepatocarcinoma: report of one case

Eighty percent of hepatocarcinomas are inoperable at the moment of diagnosis. Liver transplantation is the treatment of choice in these cases, but local therapies are another alternative. Among these, Image-Guided BrachyAblation is a safe choice. We report a 76-year-old male with a hepatocarcinoma, who was considered inoperable due to the high surgical risk of the patient. A local treatment with Image-Guided BrachyAblation was decided. A brachytherapy needle was placed in the tumor under computed tomography guidance and a 15 Gy single dose was delivered from an Iridium-192 source. The patient had no immediate complications and at one month of follow up he continued without incidents.

Multi-antigenic recombinant subunit vaccine against Lawsonia intracellularis: The etiological agent of porcine proliferative enteropathy.

Proliferative enteropathy, caused by Lawsonia intracellularis, represents a threat for swine industry. Current vaccines are effective but difficult to obtain and scaled up, because of demanding bacterial culture conditions. In this work, a subunit vaccine candidate against L. intracellularis was developed and its efficacy was evaluated in vivo, alone or co-formulated with pig recombinant IFN-α. The vaccine formulation contains three chimeric antigens: two outer membrane proteins and a secreted one, which were engineered by adding T epitopes using bioinformatics tools. After simultaneously expressing the three antigens in E. coli, its immunogenicity was tested in mice and pigs. Antigens co-formulated with porcine IFN-α were also assayed in the last species. Immune response was assessed by ELISA and qPCR, and histopathological studies of intestinal epithelial tissue were performed after challenge. Mice and pigs showed an increased IgG response against chimeric antigens. Particularly, there were significant differences in the antibody response when porcine IFN-α was co-administrated with L. intracellularis antigens. Besides, mRNAs from il12 and cd4 marker were detected during the first week after immunization of pigs, suggesting a Th1-type cellular immune response. The significant enhancement of oas2 gene expression indicates the effect exerted by porcine IFN-α. Post-mortem histopathological analysis post-challenge revealed damage only into epithelial cells of the gastrointestinal tract from animals of the negative control group. Injuries were related to atrophy of the intestinal villi, where a decrease of globet cells and a greater migration of lymphocytes were observed. Overall, our results demonstrated that the vaccine candidate elicited significant humoral and cellular immune responses. Besides, histopathological analysis suggested that vaccinated animals were protected against experimental L. intracellularis infection. This research constitutes a step forward to the generation of the first recombinant chimeric vaccine against L. intracellularis, representing a faster, easier and cost effective approach to counteract the porcine proliferative enteropathy.

Evaluación pre-post intervención de los conocimientos de infecciones de transmisión sexual en adolescentes / Evaluation before and after the intervention on the knowledge by adolescents about sexually transmitted infections

Objetivo: evaluar el impacto de una intervención acerca de los conocimientos relacionados con las infecciones de transmisión sexual (ITS) y los servicios sanitarios disponibles en adolescentes escolarizados en el barrio del Raval Nord (Barcelona). Método: estudio cuasi-experimental pre-post intervención en adolescentes mayores de 14 años escolarizados en 3º y 4º de Educación Secundaria Obligatoria y 1º y 2º de Bachillerato de tres centros. Variables: sociodemográficas, conductas de riesgo (11 ítems con respuesta escala Likert 0-10), uso de preservativo, inicio de relaciones sexuales, consumo de alcohol y otras drogas, conocimiento de servicios sanitarios y de las ITS. Intervención con tres unidades didácticas: conductas de riesgo y formas de contagio; síntomas, conocimiento y tratamiento de las ITS; uso de servicios sanitarios.Tratamiento y análisis de los datos: Chi cuadrado y U de Mann Whitney para analisis bivariante con variables sociodemográficas. Se calcularon intervalos de confianza al 95% de seguridad (IC95%). Resultados: se estudiaron 211 adolescentes, 56,8% mujeres, media de edad: 15,4 años. El 79,6% procedía de fuera de Europa. El 30,3% había iniciado relaciones sexuales y el 32,4% utilizaba siempre preservativo. El 61,9% no asoció nunca alcohol ni otras drogas en la relación. El VIH es la ITS más conocida (59,8%). Los hombres tienen una percepción de riesgo menor que las mujeres. Post-intervención la percepción de riesgo global aumenta, así como el conocimiento de los servicios sanitarios y de las ITS. Conclusiones: existe déficit de conocimientos de los adolescentes acerca de las ITS. Los conocimientos sobre las ITS, la percepción de riesgo y los recursos sanitarios mejoraron tras la intervención

Objective: to evaluate the impact of an intervention on the knowledge about sexually transmitted infections (STIs) and the healthcare services available among adolescents attending school in the Raval Nord neighborhood (Barcelona). Method: a quasi-experimental study before and after the intervention in adolescents >14-year-old attending 3rd and 4th term of Secondary School and 1st and 2nd term of High School in three centres. Variables: sociodemographical, risk behaviours (11 items with answer through the 0-10 Likert Scale), use of condoms, initiation of sexual relationships, use of alcohol and other drugs, knowledge of healthcare services and of STIs. An intervention with three educational units: risk behaviours and ways of infection; symptoms, knowledge and treatment of STIs; use of healthcare services. Data treatment and analysis: Chi Square and Mann Whitney's U for bivariate analysis with sociodemographical variables. Confidence intervals were calculated at 95% safety (CI95%). Results: the study included 211 adolescents: 56.8% were female, with 15.4 years as mean age. Of these, 79.6% came from outside Europe, 30.3% had initiated sexual relationships, and 32.4% always used condoms; 61.0% of them never associated alcohol or other drugs with their relationship. HIV was the most widely known STI (59.8%). Men had a lower perception of risk than women. After the intervention, there was an increase in their overall perception of risk, as well as in their knowledge of healthcare services and STIs. Conclusions: there is lack of knowledge among adolescents about STIs. After the intervention, there was an improvement in their knowledge of STIs and healthcare services, as well as in their perception of risk