Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience.

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. We evaluated the immunohistochemical (IHC) expression of p63 and p53 in DLBCL and their significance on overall survival (OS) and progression-free survival (PFS). We conducted a retrospective cohort study of 177 patients with DLBCL who presented to Mount Sinai Medical Center of Florida (Miami Beach, Florida) between 2010 and 2020. IHC staining for p63 and p53 protein expression was performed. A significant correlation was found between p63 positivity and p53 expression, p53/p63 co-positivity, Ki-67 proliferation index, MYC expression, and MYC/BCL2 double expression. Regardless of the germinal center B-cell like (GCB) subgrouping, there was a trend among p53+ patients to have MYC/BCL2 double expression, positive MYC expression, and lower OS and PFS. A tendency of poor OS was seen in p53+ patients in the non-GCB, GCB, and double expressors subgroups and poor PFS in p53+ patients regardless of the subgrouping. In conclusion, our results suggest that p63 and p53 may represent potential additional prognostic biomarkers in DLBCL and may be included in the initial diagnostic work up of patients with DLBCL.

RETRACTED: Bahmad et al. Histopathologic Findings Associated with Miller-Dieker Syndrome: An Autopsy Report. Diseases 2022, 10, 95.

The Journal retracts the article, Histopathologic Findings Associated with Miller-Dieker Syndrome: An Autopsy Report [...].

Histopathologic Findings Associated with Miller-Dieker Syndrome: An Autopsy Report.

Miller-Dieker syndrome (MDS) is a rare genetic disorder characterized by congenital lissencephaly (absent or diminished cerebral gyri), facial dysmorphisms, neurodevelopmental retardation, intrauterine fetal demise, and death in early infancy or childhood. We present a case of a 4-year-old girl with MDS (17p13.3p13.2 deletion) who was admitted to the hospital due to fever and increased secretions from her nose, mouth, and tracheostomy tube (as she had been on a ventilator and G-tube dependent since birth). During the course of hospitalization, she developed multiorgan failure, third spacing, and significant lactic acidosis. The patient had a cardiorespiratory arrest and expired after 4 months and 8 days of hospitalization. We provide a synopsis of the main autopsy findings, with a focus on the neuropathologic anomalies.

Hemophagocytic Lymphohistiocytosis in the Setting of Therapy-Induced Acute Myeloid Leukemia: An Autopsy Report.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory disorder that occurs due to immunologic dysregulation. HLH can be primary (hereditary) or secondary to infections, autoimmune diseases, immune deficiencies, metabolic diseases, drugs, or malignancies. Lymphoid neoplasms mostly accompany malignancy-associated HLH. We present a case of a 12-year-old boy with a history of precursor B lymphoblastic leukemia (B-ALL), who subsequently developed chemotherapy-induced acute myeloid leukemia (t-AML). The patient was admitted for febrile neutropenia and initial laboratory tests revealed hemophagocytic lymphohistiocytosis (HLH). The hospital course was complicated by multiple infections and septic shock. The patient received several broad-spectrum antimicrobials, dexamethasone, as well as a pericardial drain to drain the hemorrhagic pericardial effusion. Despite intervention, the patient expired, and an autopsy was performed. We provide a synopsis of the main autopsy findings.

Identificación molecular y diversidad genética de las especies de nematodos Globodera rostochiensis y G. pallida en regiones productoras de papa de Guatemala / Molecular identification and genetic diversity of the species of nematodesGlobodera rostochiensisandG. pallidain potato growing regions of Guatemala

En Guatemala, la producción del cultivo de papa se ve afectada por los nematodos Globodera rostochiensis y Globo-dera pallida. La capacidad de ambas especies para formar quistes complica su control y provoca el aumento de sus poblaciones. En Guatemala se reporta la presencia de ambas especies de nematodos por identificación morfológica, sin embargo, no se ha realizado una confirmación molecular. Este es el primer estudio para validar la presencia de ambas especies de nematodos por PCR múltiple y la determinación de la diversidad y estructura genética de las poblaciones utilizando marcadores moleculares. Se realizaron muestreos en cuatro departamentos productores de papa del país. La identificación por PCR se realizó con el cebador común ITS5 y los cebadores PITSr3 específico para G. rostochiensisy PITSp4 para G. pallida. La caracterización molecular se realizó con el marcador AFLP. Se confirmó la presencia de las dos especies de nematodos en los cuatro departamentos. Los índices de diversidad Shannon y heterocigosidad esperada revelaron mayor diversidad genética en G. rostochiensis (H = 0.311, He = 0.301) que en G. pallida (H = 0.035, He = 0.223). Los métodos NJ, DAPC y PCA exhibieron una débil estructura entre las poblaciones de ambas especies de nematodos. Los resultados sugieren un patrón de dispersión desde Quetzaltenango hacia el resto del país, atribuido a la comercialización de semilla contaminada con nematodos. Se sugiere promover programas de socialización sobre los beneficios del uso de semilla certificada, además de constantes monitoreos moleculares para un diagnóstico certero de ambas especies de nematodos.

In Guatemala, potato crop production is affected by the nematodes Globodera rostochiensis and Globodera pallida. The ability of both species to form cysts complicates their control and causes an increase in their populations. In Guatemala, both species of nematodes have been reported by morphological identification; however, molecular confirmation has not been carried out. It is the first study to validate the presence of both nematode species by multiplex PCR and determine the diversity and genetic structure of the populations using molecular markers. Sampling was carried out in four pota-to-producing departments of the country. PCR identification was performed with the common primer ITS5 and the primers PITSr3 specific for G. rostochiensis and PITSp4 for G. pallida. We performed molecular characterization with the AFLP marker. We confirmed the presence of the two nematode species in the four departments. Shannon diversity and expected heterozygosity indices revealed higher genetic diversity in G. rostochiensis (H = 0.311, He = 0.301) than in G. pallida (H = 0.035, He = 0.223). The NJ, DAPC, and PCA methods exhibited weak structure among populations of both nematode species. The results suggest a dispersal pattern from Quetzaltenango to the rest of the country, attributed to the commer-cialization of seed contaminated with nematodes. We suggest promoting socialization programs on the benefits of using certified seeds and constant molecular monitoring for an accurate diagnosis of both species of nematodes.

Neonatal acute liver failure with pulmonary yellow hyaline membrane and kernicterus.

BACKGROUND: Neonatal acute liver failure (NALF) is a rare and life-threatening condition. It causes bilirubin to accumulate to a dangerous level in the body, causing permanent damage to vital organs such as the brain and lungs. In many cases, the etiology of NALF remains unknown. CASE PRESENTATION: We described a case of an 8-day-old baby girl who presented with poor oral intake, lethargy, and jaundice. Her clinical condition rapidly deteriorated with progression to multi-organ failure, and despite intensive resuscitation efforts, she expired. At autopsy, the most significant findings were liver necrosis, yellow hyaline membrane deposition in the lungs, and bilirubin deposition in the brain (kernicterus). CONCLUSIONS: NALF is a rare and potentially fatal condition necessitating prompt recognition and disease-specific treatment approaches. Toxic accumulation of bilirubin in the lungs can lead to hypoxia and precipitate further ischemic injury to the liver.

Neonatal acute liver failure with pulmonary yellow hyaline membrane and kernicterus

Background Neonatal acute liver failure (NALF) is a rare and life-threatening condition. It causes bilirubin to accumulate to a dangerous level in the body, causing permanent damage to vital organs such as the brain and lungs. In many cases, the etiology of NALF remains unknown. Case presentation We described a case of an 8-day-old baby girl who presented with poor oral intake, lethargy, and jaundice. Her clinical condition rapidly deteriorated with progression to multi-organ failure, and despite intensive resuscitation efforts, she expired. At autopsy, the most significant findings were liver necrosis, yellow hyaline membrane deposition in the lungs, and bilirubin deposition in the brain (kernicterus). Conclusions NALF is a rare and potentially fatal condition necessitating prompt recognition and disease-specific treatment approaches. Toxic accumulation of bilirubin in the lungs can lead to hypoxia and precipitate further ischemic injury to the liver.

Clinical, histopathologic, and immunoarchitectural features of dermatopathic lymphadenopathy: an update.

Dermatopathic lymphadenopathy is a distinctive form of paracortical lymph node hyperplasia that usually occurs in the setting of chronic dermatologic disorders. The aim of this study is to update our understanding of the clinicopathologic and immunophenotypic features of dermatopathic lymphadenopathy. The study cohort was 50 lymph node samples from 42 patients diagnosed with dermatopathic lymphadenopathy. The patients included 29 women and 13 men with a median age of 49 years (range, 12-79). Twenty-two (52%) patients had a dermatologic disorder, including mycosis fungoides (n = 6), chronic inflammatory dermatoses (n = 13), melanoma (n = 1), squamous cell carcinoma (n = 1), and Kaposi sarcoma in the context of human immunodeficiency virus infection (n = 1). Twenty (48%) patients did not have dermatologic manifestations. Lymph node biopsy specimens were axillary (n = 22), inguinal (n = 21), cervical (n = 4), and intramammary (n = 3). All lymph nodes showed paracortical areas expanded by lymphocytes; dendritic cells, including interdigitating dendritic cells and Langerhans cells; and macrophages. Melanophages were detected in 48 (98%) lymph nodes. Immunohistochemical analysis provided results that are somewhat different from those previously reported in the literature. In the paracortical areas of lymph node, S100 protein was expressed in virtually all dendritic cells, and CD1a was expressed in a significantly greater percentage of cells than langerin (80 vs. 35%, p < 0.0001). These results suggest that the paracortical regions of dermatopathic lymphadenopathy harbor at least three immunophenotypic subsets of dendritic cells: Langerhans cells (S100+, CD1a+(high), langerin+), interdigitating dendritic cells (S100+, CD1a+(low), langerin-), and a third (S100+, CD1a-, langerin-) minor population of dendritic cells. Furthermore, in more than 60% of dermatopathic lymph nodes, langerin highlighted trabecular and medullary sinuses and cords, showing a linear and reticular staining pattern, which could be a pitfall in the differential diagnosis with Langerhans cell histiocytosis involving lymph nodes.

Pontocerebellar Hypoplasia Maps to Chromosome 7q11.23: An Autopsy Case Report of a Novel Genetic Variant.

Pontocerebellar hypoplasias are a group of autosomal recessive neurodevelopmetal disorders with varied phenotypic presentations and extensive genetic mutational landscape that are currently classified into ten subtypes. This classification is based predominantly on the genetic iterations as the phenotypic presentations are often broad and overlapping. Pontocerebellar hypoplasia type-3 (PCH3) is an autosomal recessive disorder characterized by a small cerebellar vermis, hyperreflexia, and seizures, described in Middle Eastern families in association with a homozygous truncating mutation of the PCLO gene in locus 7q11-21. This is a case of PCH, with previously unreported novel genetic alterations. The patient is a 1-week-old girl, born at term to a 26-year-old G4P0A3 woman in a nonconsanguinous relation. At birth, the baby was depressed and hypertonic with abnormal tonic-clonic movements of extremities. MRI revealed cerebellar and brainstem hypoplasia. Postmortem examination revealed a palmar simian crease. The cerebellum measured 2.5 cm from side to side and 1 cm from rostral to caudal. The vermis was rudimentary. Sectioning revealed a flattened linear fourth ventricle, scant abortive cerebellar foliae, and a markedly small cerebellum when compared with the cerebrum and with age-matched size. H&E-stained sections of cerebellum revealed scant rudimentary foliae. A rudimentary unilateral embolliform nucleus was identified. The remaining cerebellar nuclei were absent. Chromosomal microarray showed an interstitial duplication of 841 kB on chromosome 7q11.23. Locus 7q11.23 contains FGL2 and GSAP genes and is 5 MB upstream of the 7q11-21 region, suggesting a possible linkage. This novel genomic finding possibly represents a new familial variant of PCH closely associated with PCH-3 and further strengthens its association with the 7q11 locus.

Spontaneous perforation of small intestine followed by rupture of the cystic artery: the natural history of Vascular Ehlers-Danlos Syndrome.

Vascular Ehlers-Danlos Syndrome (VEDS) is a rare autosomal dominant disorder caused by mutations in the COL3A1 or COL1A1 genes. Its mortality is secondary to sudden and spontaneous rupture of arteries or hollow organs. The genotype influences the distribution of arterial pathology with aneurysms of intra-abdominal visceral arteries being relatively uncommon. We describe the case of a young man with probable VEDS who died of a spontaneous rupture and dissection of the cystic artery. The patient initially presented with abdominal pain due to an unrecognized spontaneous perforation of the small intestine complicated by sepsis. We postulate that inflammatory mediators may have triggered the arterial rupture due to remodeling and weakening of vessel walls. The phenotype of the patient's vascular damage included bilateral spontaneous carotid-cavernous sinus fistulae and dissection with pseudoaneurysm formation of large- and medium-sized arteries, predominantly the abdominal aorta and its branches. The autopsy uncovered a long history of vascular events that may have been asymptomatic. These findings along with a positive family history supported the VEDS diagnosis. Loeys-Dietz, Marfan, and familial thoracic aortic aneurysm and dissection syndromes were ruled out based on the absence of arterial tortuosity, eye abnormalities, bone overgrowth, and the distribution of vascular damage among other features. Interestingly, microscopic examination of the hippocampus revealed a focus of neuronal heterotopia, commonly associated with epilepsy; however, the patient had no history of seizures. The natural course of VEDS involves the rupture and dissection of arteries that, if unrecognized, can lead to a rapid death after bleeding into free spaces.

Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry.

Leptomeningeal dissemination in children is typical of high-grade, and occasionally low-grade, neoplasms. Rare cases of widely disseminated oligodendroglia-like leptomeningeal tumors, sometimes with associated spinal cord lesions, have been described that respond to treatment and follow an indolent course. Whether these lesions represent an established tumor category or are a unique entity remains to be established. We present 9 pediatric cases of such diffuse leptomeningeal neuroepithelial tumors (DLNT), 8 with assessment of 2 common genetic alterations seen in oligodendrogliomas, 1p and 19q chromosomal deletions and isocitrate dehydrogenase-1 (IDH1) R132H mutations. Four patients were male and 5 female, with a mean age at presentation of 4 years (range, 2 to 7 y). All presented with signs of increased intracranial pressure and diffuse contrast enhancement of the leptomeninges by magnetic resonance imaging. Three had a cervical or upper thoracic spinal cord tumor, and another had a small cerebellar lesion. Leptomeningeal biopsies showed a thickened and fibrotic arachnoid infiltrated by monotonous cells with round nuclei and prominent perinuclear clearing. All cases were strongly immunoreactive for S100 protein, and most showed faint granular synaptophysin reactivity. Six of 8 cases showed deletions of chromosome arm 1p by fluorescence in situ hybridization, 2 of which also had loss of 19q. None of the lesions reacted with IDH1-R132H antibodies. Although the clinicopathologic features show overlap of these DLNT lesions with oligodendroglioma and extraventricular neurocytoma, they do not exactly match either one, suggesting that DLNTs are a distinct tumor entity.

Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature.

PURPOSE: Desmoplastic infantile gangliogliomas (DIGs) are rare tumors of infancy. Herein, we describe an unusual case of DIG diagnosed by prenatal ultrasound. METHODS: This 5-day-old newborn was delivered after a prenatal ultrasound revealed a large cystic mass in the left cerebral hemisphere along with an echogenic solid component. RESULTS: The tumor revealed a glial and neuronal proliferation in a background of desmoplasia more typical of DIG and a minor component with a more primitive, immature appearance to the glioneuronal elements. A significant component of the tumor was composed of pleomorphic eosinophilic spindle cells in whorls and interlacing fascicles that showed a strong, sharp, and diffuse positivity for desmin, thus mimicking rhabdomyosarcoma. However, the tumor cells were GFAP (+), INI-1 (+), and myogenin (-). Mitoses were seen both in the more spindle cell astroglial areas as well as the more primitive neuroepithelial cells. The MIB-1 proliferation index was brisk, exceeding 15 %, and in areas it was estimated to be as high as 30 %. Such high proliferation index has been described and accepted in the more primitive neuroepithelial areas, but not in the terminally differentiated, spindle cell astroglial areas as in our case. Our patient was incidentally diagnosed prenatally. To our knowledge, this case is the first documented congenital DIG diagnosed prenatally. CONCLUSIONS: This case highlights the pitfalls in diagnosing DIG, which can mimic a rhabdomyosarcoma. Furthermore, it underscores the importance of re-evaluating the grading of these tumors or at least segregating the variants where the prognosis may be more guarded.

Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with neurotoxoplasmosis coinfection in a patient with advanced HIV infection.

We describe a patient with advanced HIV infection and Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with Toxoplasma gondii coinfection. A multidisciplinary effort and state-of-the-art diagnostic techniques were required for diagnosis. Our patient is the first reported case of an HIV-infected person with dual Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with neurotoxoplasmosis coinfection.

Urgencias estomatológicas en pacientes con VIH/SIDA de la Clínica Estomatológica Docente Yuri Gómez Reinoso / Stomatology urgencies in HIV/AIDS patients in Yuri Gómez Reinoso Stomatology Teaching Clinic

Se realizó un estudio observacional descriptivo transversal con el objetivo de identificar la edad, el sexo y la frecuencia de urgencias estomatológicas y su relación con el tiempo de infección por el virus de inmunodeficiencia humana y el consumo de antirretrovirales. El universo lo constituyeron 32 pacientes mayores de edad, con infección por el virus de inmunodeficiencia humana/síndrome de inmunodeficiencia adquirida, que se presentaron con urgencias estomatológicas en la clínica Yuri Gómez Reinoso, en La Habana, Cuba, entre el mes de enero de 2008 e igual mes de 2010. Resultó que el 68,75 por ciento correspondieron al sexo masculino, el 31,25 por ciento con edades de 31 a 40 años, el 25 por ciento presentaron estomatitis aftosa recurrente, el 21,8 por ciento absceso dentoalveolar agudo, el 15,62 por ciento pulpitis irreversible aguda y candidiasis eritematosa y el 37,5 por ciento xerostomía. El 46,87 por ciento de los pacientes con infección por el virus de 6 a 10 años de diagnóstico presentaron urgencias. El 46,9 por ciento de los pacientes, no consumían medicamentos antirretrovirales y el 53,1 por ciento sí lo consumían. Estas diferencias no fueron estadísticamente significativas (p= 0,8026). Se concluyó que en los pacientes estudiados, predominó el sexo masculino y los mayores de 31 años. Los tipos de urgencias mayormente tratadas fueron: estomatitis aftosa recurrente, absceso dentoalveolar agudo, pulpitis irreversible y candidiasis eritematosa. En la investigación no se constaron diferencias entre la presencia de urgencias y el consumo de antirretrovirales(AU)

A cross-sectional, descriptive and observational study was conducted to identify age, sex and frequency of Stomatology urgencies and its relation to time of infection from HIV and of antiretroviral consumption drugs. Universe included 32 HIV/AIDS adult patients came with Stomatology urgencies in the Yuri Gómez Reinoso Teaching Clinic between January, 2008 and January, 2010. The 68,75 percent corresponded to male sex, the 31,25 percent aged from 31 to 40, the 125 percent had recurrent aphthous stomatitis, the 21,8 percent had acute dentoalveolar abscess and the 15,62 percent had acute irreversible pulpitis and erythematous candidiasis, the 37,5 percent had Xerostomia. The 46,87 percent of patients with HIV from 6 to 10 years of diagnosed had urgencies. The 46,9 percent had no of antiretroviral drugs consumption but the 53,1 percent yes; these differences were not statistically significant (p= 0.8026). We conclude that in study patients there was predominance of male sex and age over 31 years; the urgency types: recurrent aphthous stomatitis, acute dentoalveolar abscess, irreversible pulpitis and erythematous candidiasis in decreasing order without differences between the urgency presence and antiretroviral drugs consumptio(AU)

Urgencias estomatológicas en pacientes con VIH/SIDA de la Clínica Estomatológica Docente Yuri Gómez Reinoso / Stomatology urgencies in HIV/AIDS patients in Yuri Gómez Reinoso Stomatology Teaching Clinic

Se realizó un estudio observacional descriptivo transversal con el objetivo de identificar la edad, el sexo y la frecuencia de urgencias estomatológicas y su relación con el tiempo de infección por el virus de inmunodeficiencia humana y el consumo de antirretrovirales. El universo lo constituyeron 32 pacientes mayores de edad, con infección por el virus de inmunodeficiencia humana/síndrome de inmunodeficiencia adquirida, que se presentaron con urgencias estomatológicas en la clínica Yuri Gómez Reinoso, en La Habana, Cuba, entre el mes de enero de 2008 e igual mes de 2010. Resultó que el 68,75 por ciento correspondieron al sexo masculino, el 31,25 por ciento con edades de 31 a 40 años, el 25 por ciento presentaron estomatitis aftosa recurrente, el 21,8 por ciento absceso dentoalveolar agudo, el 15,62 por ciento pulpitis irreversible aguda y candidiasis eritematosa y el 37,5 por ciento xerostomía. El 46,87 por ciento de los pacientes con infección por el virus de 6 a 10 años de diagnóstico presentaron urgencias. El 46,9 por ciento de los pacientes, no consumían medicamentos antirretrovirales y el 53,1 por ciento sí lo consumían. Estas diferencias no fueron estadísticamente significativas (p= 0,8026). Se concluyó que en los pacientes estudiados, predominó el sexo masculino y los mayores de 31 años. Los tipos de urgencias mayormente tratadas fueron: estomatitis aftosa recurrente, absceso dentoalveolar agudo, pulpitis irreversible y candidiasis eritematosa. En la investigación no se constaron diferencias entre la presencia de urgencias y el consumo de antirretrovirales(AU)

A cross-sectional, descriptive and observational study was conducted to identify age, sex and frequency of Stomatology urgencies and its relation to time of infection from HIV and of antiretroviral consumption drugs. Universe included 32 HIV/AIDS adult patients came with Stomatology urgencies in the Yuri Gómez Reinoso Teaching Clinic between January, 2008 and January, 2010. The 68,75 percent corresponded to male sex, the 31,25 percent aged from 31 to 40, the 125 percent had recurrent aphthous stomatitis, the 21,8 percent had acute dentoalveolar abscess and the 15,62 percent had acute irreversible pulpitis and erythematous candidiasis, the 37,5 percent had Xerostomia. The 46,87 percent of patients with HIV from 6 to 10 years of diagnosed had urgencies. The 46,9 percent had no of antiretroviral drugs consumption but the 53,1 percent yes; these differences were not statistically significant (p= 0.8026). We conclude that in study patients there was predominance of male sex and age over 31 years; the urgency types: recurrent aphthous stomatitis, acute dentoalveolar abscess, irreversible pulpitis and erythematous candidiasis in decreasing order without differences between the urgency presence and antiretroviral drugs consumptio(AU)

Medically intractable epilepsy in Sturge-Weber syndrome is associated with cortical malformation: implications for surgical therapy.

PURPOSE: Anecdotal reports have described cortical malformations in epileptic patients with Sturge-Weber syndrome (SWS). No data are available regarding the prevalence and significance of this association. METHODS: We reviewed retrospectively the clinical profile, preoperative magnetic resonance imaging (MRI) studies, and pathology reports of all patients with SWS and medically intractable epilepsy evaluated in our epilepsy surgery program between 1979 and 2006. RESULTS: Twelve patients (male/female = 7/5) were identified. Mean age at seizure onset was 11.1 +/- 16.7 months. Seizures occurred daily in seven patients and weekly in five patients. A facial port-wine stain was noted in 10 cases. Eleven patients evidenced developmental delay and eight were hemiparetic. Eight patients underwent excisional surgery for epilepsy (mean age 10.3 +/- 6.5 year), including hemispherectomy (n = 4) and focal cortical resection (n = 4). Tissue was available for neuropathology in six operated cases and revealed polymicrogyria (n = 3) and cortical dysplasia (n = 4). Polymicrogyria was associated with cortical dysplasia in one child. Brain MRIs were reviewed in 10 of 12 patients and were consistent with cortical malformations in all cases. CONCLUSIONS: We conclude that cortical malformations are frequent in patients with medically intractable epilepsy and Sturge-Weber-syndrome and may be the primary cause of epilepsy.

Caries dental y factores de riesgo en adultos jóvenes: Distrito Capital, Venezuela / Dental caries and risk factors present in young adults

Se realizó un estudio epidemiológico transversal o de prevalencia con el objetivo de describir la morbilidad por caries dental y factores de riesgo seleccionados en adultos jóvenes en el periodo de enero de 2006 a diciembre de 2006, en el municipio Libertador del Distrito Capital. El universo de estudio estuvo conformado 245 trabajadores sociales venezolanos luchadores sociales, que laboraron en la Misión Energía. Se confeccionó un formulario en el cual se recogió toda la información necesaria, se utilizó para ellos los métodos empíricos de la observación e interrogatorio al paciente, se determinó la morbilidad de la caries dental así como la asociación entre estas y factores de riesgos modificables y se calcularon los indicadores de riesgo e impacto potencial. El 90,6 por ciento de los examinados presentaron caries dental, la edad màs afectada fue la de 30 años y màs con un 94,4 por ciento y el sexo masculino con un 91,2 por ciento, aunque no se determinaron diferencias significativas en cuanto a ellas (p> 0,05). Se determinó asociación significativa en orden de importancia entre las caries y la experiencia anterior de la enfermedad (razón de prevalencia (RP)= 2,63; fracción etiológica en los expuestos (EEe)= 62,0 y fracción etiológica en la población (FEp)= 55,1); ingestión de dieta cariogénica (RP= 2,33; FEe= 57,1 y FEp= 49,9); higiene bucal no adecuada (RP= 1,63, FEe= 38,6 y FEp= 31,55); nivel de conocimiento no adecuado sobre salud bucal (RP= 1,30, FEe= 23,1 y FEp= 16,4) y la no visita sistemßtica a la consulta estomatológica (RP= 1,27; FEe= 21,3 y FEp= 15,5). Se recomienda diseñar y aplicar estrategias de intervención educativas con participación comunitaria, con el objetivo de modificar los conocimientos, actitudes y pràcticas para la prevención de la Caries dental(AU)

A cross-sectional epidemiologic or of prevalence study was conducted to describe the morbidity by dental caries and risk factors selected in young adults from January, 2006 to December, 2006 in Libertador municipality, Distrito Capital. Universe included 245 Venezuelan social workers social fighters, located in Energy Mission. A form was designed in which was recorded all information need using empirical methods of observation and questioning to patients, determining the morbidity of dental caries as well as the association each other, and risk factors modifiable , estimating also the potential risk and social impact indicators. The 90,6 percent of person polled had dental caries the more affected were those aged 30 and more with 94,4 percent and male sex with a 91,2 percent although there were not significant differences related to it (p> 0.05). In significance order there was a significant difference among the cries and the prior experience of disease (odds ratio (OR)= 2.63). Etiological fraction in those exposed (EEe)= 62,0 and etiological fraction in population (FEp)= 55,1), ingestion of cariogenic diet (RP= 2.33, Fee= 57,1 and FEp= 49.9), inappropriate oral hygiene (RP= 1,63, Fee= 38.6 and FEp= 31.55), non-suitable knowledge level on oral health (RP= 1.30, Fee= 23.1 and FEp= 16.4), and the non systematic visit to Stomatology consultation (RP= 1.27, Fee= 21,3 and FEp= 15.5). It is advisable to design and to apply educational interventional strategies with community involvement to modify the knowledges, attitudes and practices to prevent dental caries(AU)

Caries dental y factores de riesgo en adultos jóvenes: Distrito Capital, Venezuela / Dental caries and risk factors present in young adults

Se realizó un estudio epidemiológico transversal o de prevalencia con el objetivo de describir la morbilidad por caries dental y factores de riesgo seleccionados en adultos jóvenes en el periodo de enero de 2006 a diciembre de 2006, en el municipio Libertador del Distrito Capital. El universo de estudio estuvo conformado 245 trabajadores sociales venezolanos luchadores sociales, que laboraron en la Misión Energía. Se confeccionó un formulario en el cual se recogió toda la información necesaria, se utilizó para ellos los métodos empíricos de la observación e interrogatorio al paciente, se determinó la morbilidad de la caries dental así como la asociación entre estas y factores de riesgos modificables y se calcularon los indicadores de riesgo e impacto potencial. El 90,6 por ciento de los examinados presentaron caries dental, la edad màs afectada fue la de 30 años y màs con un 94,4 por ciento y el sexo masculino con un 91,2 por ciento, aunque no se determinaron diferencias significativas en cuanto a ellas (p> 0,05). Se determinó asociación significativa en orden de importancia entre las caries y la experiencia anterior de la enfermedad (razón de prevalencia (RP)= 2,63; fracción etiológica en los expuestos (EEe)= 62,0 y fracción etiológica en la población (FEp)= 55,1); ingestión de dieta cariogénica (RP= 2,33; FEe= 57,1 y FEp= 49,9); higiene bucal no adecuada (RP= 1,63, FEe= 38,6 y FEp= 31,55); nivel de conocimiento no adecuado sobre salud bucal (RP= 1,30, FEe= 23,1 y FEp= 16,4) y la no visita sistemática a la consulta estomatológica (RP= 1,27; FEe= 21,3 y FEp= 15,5). Se recomienda diseñar y aplicar estrategias de intervención educativas con participación comunitaria, con el objetivo de modificar los conocimientos, actitudes y pràcticas para la prevención de la Caries dental(AU)

A cross-sectional epidemiologic or of prevalence study was conducted to describe the morbidity by dental caries and risk factors selected in young adults from January, 2006 to December, 2006 in Libertador municipality, Distrito Capital. Universe included 245 Venezuelan social workers social fighters, located in Energy Mission. A form was designed in which was recorded all information need using empirical methods of observation and questioning to patients, determining the morbidity of dental caries as well as the association each other, and risk factors modifiable , estimating also the potential risk and social impact indicators. The 90,6 percent of person polled had dental caries the more affected were those aged 30 and more with 94,4 percent and male sex with a 91,2 percent although there were not significant differences related to it (p> 0.05). In significance order there was a significant difference among the cries and the prior experience of disease (odds ratio (OR)= 2.63). Etiological fraction in those exposed (EEe)= 62,0 and etiological fraction in population (FEp)= 55,1), ingestion of cariogenic diet (RP= 2.33, Fee= 57,1 and FEp= 49.9), inappropriate oral hygiene (RP= 1,63, Fee= 38.6 and FEp= 31.55), non-suitable knowledge level on oral health (RP= 1.30, Fee= 23.1 and FEp= 16.4), and the non systematic visit to Stomatology consultation (RP= 1.27, Fee= 21,3 and FEp= 15.5). It is advisable to design and to apply educational interventional strategies with community involvement to modify the knowledges, attitudes and practices to prevent dental caries(AU)