Whose Signals Are Being Amplified? Toward a More Equitable Clinical Psychophysiology.

Research using psychophysiological methods holds great promise for refining clinical assessment, identifying risk factors, and informing treatment. Unfortunately, unique methodological features of existing approaches limit inclusive research participation and, consequently, generalizability. This brief overview and commentary provides a snapshot of the current state of representation in clinical psychophysiology, with a focus on the forms and consequences of ongoing exclusion of Black participants. We illustrate issues of inequity and exclusion that are unique to clinical psychophysiology, considering intersections among social constructions of Blackness and biased design of current technology used to measure electroencephalography, skin conductance, and other signals. We then highlight work by groups dedicated to quantifying and addressing these limitations. We discuss the need for reflection and input from a wider variety of stakeholders to develop and refine new technologies, given the risk of further widening disparities. Finally, we provide broad recommendations for clinical psychophysiology research.

Examining the Qualitative Experiences of Latinx Nurses During the First Wave of COVID-19.

Introduction: The world has been impacted by the coronavirus disease 2019 (COVID-19) pandemic since March of 2020. Latinx nurses have been some of the most underrepresented in being studied during this time and have been greatly affected by it. To the best of our knowledge, there are no published studies that focus on the qualitative experiences of Latinx nurses during the first wave of the pandemic. Methods: Data analysis included thematic analysis to identify main themes experienced by Latinx nurses. A qualitative descriptive study design was employed to conduct a parent study with 100 nurses across the United States reflecting on their experiences during the first wave of the COVID-19 pandemic, data collected from May to September 2020. Formal coding of the interview data was conducted utilizing Dedoose cloud-based software. Results: Five main themes emerged, including (1) connection to patients' personal touch and empathy, (2) connection to Latinx nurses, (3) connection to family and friends, (4) connection to food as care, and (5) coping. Within the theme of coping, subthemes of (5.1) faith, (5.2) maladaptive behaviors, and (5.3) self-care activities emerged. Conclusion: These experiences can help shape the pathway to be better prepared for any emergency or future pandemic.

Thermal Imaging to Assess the Health Status in Wildlife Animals under Human Care: Limitations and Perspectives.

Promoting animal welfare in wildlife species under human care requires the implementation of techniques for continuously monitoring their health. Infrared thermography is a non-invasive tool that uses the radiation emitted from the skin of animals to assess their thermal state. However, there are no established thermal windows in wildlife species because factors such as the thickness or color of the skin, type/length of coat, or presence of fur can influence the readings taken to obtain objective, sensitive values. Therefore, this review aims to discuss the usefulness and application of the ocular, nasal, thoracic, abdominal, and podal anatomical regions as thermal windows for evaluating zoo animals' thermal response and health status. A literature search of the Web of Science, Science Direct, and PubMed databases was performed to identify relevant studies that used IRT with wild species as a complementary diagnostic tool. Implementing IRT in zoos or conservation centers could also serve as a method for determining and monitoring optimal habitat designs to meet the needs of specific animals. In addition, we analyze the limitations of using IRT with various wildlife species under human care to understand better the differences among animals and the factors that must be considered when using infrared thermography.

Working Memory, Attention, and Inhibitory Control in Adolescents with Suicidal Behavior: A Pilot Study / La memoria de trabajo, la atención y el control inhibitorio en los adolescentes con conducta suicida: un estudio piloto

Suicide in people between the ages of 15 and 24 is one of the top three causes of death. The aim of this research is to compare and associate performance in working memory, attention, and inhibitory control with the presence of suicidal behavior in adolescents. Research design was cross-sectional and the convenience sample consisted of 65 adolescents from the city of Temuco, Chile. The instruments used for data collection were: 1) the Okasha Suicidality Scale, 2) span of direct and indirect digits, and 3) the Stroop test. The results show that 49.3% of the adolescents had suicidal ideation. In terms of the groups, an association and significant differences were found in the Stroop test; this occurred specifically in the female sex (p < .05). In the rest of the tasks that measured memory and attention, no differences were observed (p > .05). It is concluded that suicidal behavior is associated with a lower performance in inhibitory control tasks for females. (AU)

El suicidio en personas entre 15 y 24 años es una de las tres primeras causas de muerte. El objetivo de este trabajo ha sido determinar la asociación de la memoria de trabajo, la atención y el control inhibitorio con la presencia de conducta suicida en adolescentes. Se ha utilizado un diseño de investigación transversal y una muestra por conveniencia compuesta por 65 adolescentes de la ciudad de Temuco, Chile. En la recolección de datos se utilizaron :1) la Escala de Suicidalidad Okasha, 2) la amplitud de dígitos directos e indirectos y 3) el test de Stroop. En el 49.3% de los adolescentes se presentó ideación suicida, encontrando diferencias significativas en el test de Stroop, esto ocurre específicamente en el sexo femenino (p < .05). Se concluye que la conducta suicida está asociada a un desempeño más bajo en tareas de control inhibitorio para el sexo femenino. (AU)

Estrategias para la modificación conductual en niños / Strategies for behavior modification in children

Los trastornos de conducta en niños son motivo de consulta frecuente. Sus causas son variadas incluyendo desde factores biológicos hasta condiciones psicosociales particulares. La intervención psicológica debe considerar características individuales del niño y su familia, previo a suimplementación. Así se entregan orientaciones generales para el manejo conductual de niños y adolescentes, siendo la base de estas estrategias: las prácticas de buen trato, vinculación positiva con los niños, la congruencia y la constancia en el tiempo.

Conduct disorder in children are frequent consultation. Its causes are varied including from biological factors to specific psychosocial conditions. Psychological intervention should consider individual characteristics of the child and his / her family, prior to implementation. So general guidelines for behavior management of children and adolescents are given, being the basis of these strategies: good treatment practices, positive relationship with children, consistency and constancy in time.

Process and outcome constructs for evaluating community-based participatory research projects: a matrix of existing measures.

Community-based participatory research (CBPR) has been widely used in public health research in the last decade as an approach to develop culturally centered interventions and collaborative research processes in which communities are directly involved in the construction and implementation of these interventions and in other application of findings. Little is known, however, about CBPR pathways of change and how these academic-community collaborations may contribute to successful outcomes. A new health CBPR conceptual model (Wallerstein N, Oetzel JG, Duran B et al. CBPR: What predicts outcomes? In: Minkler M, Wallerstein N (eds). Communication Based Participatory Research, 2nd edn. San Francisco, CA: John Wiley & Co., 2008) suggests that relationships between four components: context, group dynamics, the extent of community-centeredness in intervention and/or research design and the impact of these participatory processes on CBPR system change and health outcomes. This article seeks to identify instruments and measures in a comprehensive literature review that relates to these distinct components of the CBPR model and to present them in an organized and indexed format for researcher use. Specifically, 258 articles were identified in a review of CBPR (and related) literature from 2002 to 2008. Based on this review and from recommendations of a national advisory board, 46 CBPR instruments were identified and each was reviewed and coded using the CBPR logic model. The 46 instruments yielded 224 individual measures of characteristics in the CBPR model. While this study does not investigate the quality of the instruments, it does provide information about reliability and validity for specific measures. Group dynamics proved to have the largest number of identified measures, while context and CBPR system and health outcomes had the least. Consistent with other summaries of instruments, such as Granner and Sharpe's inventory (Granner ML, Sharpe PA. Evaluating community coalition characteristics and functioning: a summary of measurement tools. Health Educ Res 2004; 19: 514-32), validity and reliability information were often lacking, and one or both were only available for 65 of the 224 measures. This summary of measures provides a place to start for new and continuing partnerships seeking to evaluate their progress.

Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.

Endothelin is a potent vasoconstrictor often up-regulated in hypertension. Endothelin vasoconstriction is mediated via the G-protein coupled endothelin A (ETA) receptor present on vascular smooth muscle. Endothelin receptor antagonists (ERAs) have been shown to antagonize ET-induced vasoconstriction. We describe the primary pharmacology of darusentan, a propanoic acid based ERA currently in phase 3 clinical trials for resistant hypertension. Darusentan was tested in membrane-, cell-, and tissue-based assays to determine its biochemical and functional potency. Rat aortic vascular smooth muscle cells (RAVSMs) were characterized using flow cytometry. RAVSM membrane fractions tested in saturation experiments exhibited moderate endothelin receptor density. Receptor counting revealed that >95% of the endothelin receptors in these fractions were the ETA subtype. (S)-Darusentan competed for radiolabeled endothelin binding in RAVSM membranes with single-site kinetics, exhibiting a Ki = 13 nmol/L. (R)-Darusentan exhibited no binding activity. In cultured RAVSMs, endothelin induced increases in inositol phosphate and Ca2+ signaling, both of which were attenuated by (S)-darusentan in a concentration-dependent manner. In isolated endothelium-denuded rat aortic rings, (S)-darusentan inhibited endothelin-induced vascular contractility with a pA2 = 8.1 +/- 0.14 (n = 4 animals; mean +/- SD). (R)-Darusentan had no effect. The vasorelaxant potency of (S)-darusentan did not change when determined in isolated denuded rat mesenteric arterioles, suggesting a similar mode of action in both conductance and resistance arteries. In vascular smooth muscle, (S)-darusentan is an ERA with high affinity for the ET receptor, which in this preparation is predominantly ETA receptors. (S)-Darusentan inhibits endothelin-induced signaling related to pro-contractile activity and is a potent inhibitor of vasoconstriction in large and small arteries.

Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats.

Hepatic and circulating endothelin-1 (ET-1) are increased in patients with cirrhosis and in cirrhotic animals. However, the distinct roles of ET receptor subtypes ETA and ETB in cirrhosis and portal hypertension (PHT) have not been clearly elucidated. Thus, we studied the effects of selective ET-1 antagonists (ETA-ant or ETB-ant) and nonselective ET-1 antagonist (ETA/B-ant) on hepatic hemodynamics in cirrhotic rats. Liver fibrosis and PHT were induced by complete bile duct ligation (BDL) in rats. Two weeks after BDL or sham surgery, hemodynamic responses were measured during intraportal infusion of incremental doses of the following ET-ants: (i) BQ-123, (ii) BQ-788, and (iii) bosentan. After equilibration with vehicle, doses of ET-ants were infused for 30 min periods, and steady-state systemic and hepatic hemodynamics, portal venous pressure (PVP), and hepatic blood flow (HBF) were measured. BDL induced significant PHT and elevated concentrations of plasma ET-1 compared with sham. ETA-ant decreased PVP of cirrhotic rats but had no effect on sham, whereas ETB-ant increased PVP in sham but had no effect in BDL. Nonselective ETA/B-ant decreased PVP of BDL similarly to ETA-ant. Both ETA-ant and ETB-ant decreased local HBF, whereas a nonselective antagonist did not change HBF in sham; however no significant changes were observed in HBF of BDL rats with any of the antagonists. These findings suggest ETA activation contributes to PHT in cirrhotic rats, whereas ETB-mediated portal depressor effects are attenuated in cirrhotic rats compared with noncirrhotic rats.