Tumor de células granulares da mama: relato de um caso / Granular cells tumor of the breast: report of a case

Relatamos um raro caso de tumor de células granulares da mama, que pode simular um carcinoma tanto clinicamente quanto radiologicamente. Trata-se de uma paciente de 57 anos de idade, sem antecedentes familiares, apresentando nódulo palpável no quadrante inferior externo da mama direita, de consistência endurecida e contorno espiculado, de tamanho mamográfico de 14mm, BI-RADS V. Realizou-se biópsia excisional que diagnosticou tumor de células granulares. Microscopicamente, evidenciaram-se típicas células de citoplasma granular positivas para proteína S-100. Tal tumor é freqüentemente localizado na língua, podendo ocorrer em diversos órgãos. Na mama, aparece sobretudo em mulheres de idade mediana, pré-menopáusicas, localizando-se preferencialmente no quadrante superior interno. Geralmente apresenta bordas mal definidas com características infiltrativas

Tumor de Franz: relato de um caso / Frantz's tumor: report of a case

O tumor de Frantz é uma neoplasia rara do pâncreas. Ocorre principalmente em pacientes jovens e apresenta umbom prognóstico. Pouco mais de 300 casos foram relatados na literatura mundial. Os autores apresentam um casode Tumor de Frantz, em uma paciente do sexo feminino cuja apresentação clínica foi de massa abdominal palpável.A tomografia computadorizada (TC) associada à ultrassonografia (US) evidenciaram presença de massa sólidocística.Dois terços destes tumores ocorrem no corpo e cauda do pâncreas, e apesar do crescimento excessivopara fora dos limites pancreáticos, raramente invadem estruturas vasculares ou órgãos adjacentes, o que correspondeuaos achados intraoperatórios do caso. A paciente foi submetida a pancreatectomia corpo-caudal com preservaçãodo baço. À microscopia foram evidenciadas cavidades císticas com ocasionais estruturas papilíferas. A pacienteencontra-se sem evidência da doença 24 meses após a operação. Enfatiza-se a necessidade de se considerar otumor de Frantz no diagnóstico diferencial de massa abdominal em pacientes jovens.

Frantz´s tumor is a rare neoplasia of the pancreas that occur mainly in teenage patients with a good prognosis. Alittle over 300 cases have been reported in the literature worldwide. The autors present a case of Frantz's tumor ona female patient, whose presentation was palpable abdominal mass. CT scans and ultrasound imaging showed asolid cystic mass. Two thirds of these tumors occur at the body or tail of the pancreas, and in spite of the excessivegrowth around the pancreas, it rarely invades vascular structures or adjacent organs, what could have been seenintraoperatively in this case. The patient was submitted to a partial pancreatectomy of body and tail with preservation of the spleen. Microscopic examination displayed evident cystic cavities with occasional papillary structures. The patient is disease-free 24 months after the operation. We emphasize the need to consider tumor of Frantz as a differential diagnosis for abdominal masses in youngsters.

Meigs' syndrome with elevated CA 125: case report

CONTEXT: Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs' syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs' syndrome with elevated CA 125 level. OBJECTIVE: This is a case report of Meigs' syndrome with elevated CA 125 level. CASE REPORT: A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation