Cystic fibrosis: when neonatal screening is unsatisfactory for early diagnosis / Fibrose cística: quando a triagem neonatal é insatisfatória para o diagnóstico precoce

Abstract Introduction: cystic fibrosis newborn screening must enable its earlier diagnosis, which may enhance outcomes. This study was a series case of delayed-diagnosis children submitted to cystic fibrosis newborn screening. Description: fourteen children were included; eight (57.1%) were due to false-negative screening, while six (42.9%) were due to processing errors. Two samples collected after 30 days of life were incorrectly classified as negative, and four infants with a positive test could not be located due to screening processing errors. Cystic fibrosis diagnosis was confirmed at a median (IQR) age of 5.3 (4.2-7.4) months. Poor nutritional status was the most prevalent clinical sign at diagnosis, being present in 78.6% of infants. The mean (SD) weight-for-length and length-for-age Z-scores were -3.46 (0.84) and -3.99 (1.16), respectively. Half of the children had Pseudo-Bartter syndrome, and 42.9% had breathing difficulties. Twelve children (85.7%) required hospitalization, with a median (IQR) length of stay of 17.0 (11.5-26.5) days. Discussion: newborn screening had some faults, from incorrect collections to inefficient active search. Early identification of these children in which screening was unsatisfactory is essential, emphasizing the importance and efforts to not miss them. In the case of a failed test, healthcare professionals must be prepared to recognize the main symptoms and signs of the disease.

Resumo Introdução: a triagem neonatal para fibrose cística deve contribuir para diagnóstico precoce e melhor prognóstico da doença. O estudo é uma série de casos com lactentes submetidos à triagem, porém com diagnóstico tardio da doença. Descrição: quatorze crianças foram incluídas; oito (57,1%) com triagem falso-negativo e seis (42,9%) com erros processuais na triagem neonatal. Duas amostras foram coletadas tardiamente, sendo incorretamente classificadas como negativas e quatro lactentes com triagem positiva não foram localizados, por erros na busca ativa. Confirmou-se o diagnóstico da fibrose cística com idade mediana (IIQ) de 5,3 (4,2-7,4) meses. O Comprometimento nutricional precoce foi o sinal clínico mais prevalente ao diagnóstico, presente em 78,6% das crianças. Os Z escores médios (SD) do peso para altura e altura para idade foram -3,46 (0,84) e -3,99 (1,16), respectivamente. Metade das crianças teve síndrome de Pseudo-Bartter e 42,9% dificuldade respiratória. Doze crianças (85,7%) precisaram hospitalização com tempo mediano de permanência de 17 dias. Discussão: a triagem neonatal para fibrose cística apresentou falhas, desde testes falso-negativos, coletas incorretas, até problemas com a busca ativa. Entretanto, o diagnóstico ágil é essencial e os profissionais de saúde devem reconhecer os sintomas e sinais precoces da doença, mesmo quando a triagem neonatal não for satisfatória.

Sympathetic neural overdrive and diminished exercise capacity in reduced ejection fraction heart failure related to anthracycline-based chemotherapy.

Cardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related to anthracycline-based chemotherapy with or without chest radiation (HFrEFCA), 10 patients with heart failure with reduced ejection not related to cancer therapy (HFrEF), and 16 age- and body mass index (BMI)-matched healthy control subjects were studied. Left ventricular ejection fraction (LVEF, echocardiography), peak oxygen consumption (peak V̇o2, cardiopulmonary exercise test), muscle sympathetic nerve activity (MSNA, microneurography), and forearm blood flow (FBF, venous occlusion plethysmography) were measured. We found that peak oxygen consumption peak V̇o2 and LVEF were significantly reduced in patients with HFrEFCA compared with that of control subjects (P < 0.0001) but similar to those found in patients with HFrEFCA. The sympathetic nerve activity burst frequency and incidence were significantly higher in patients with HFrEFCA than that in control subjects (P < 0.0001). No differences were found between patients with HFrEF and HFrEFCA. Peak V̇o2 was inversely associated with MSNA burst frequency (r = -0.53, P = 0.002) and burst incidence (r = -0.38, P = 0.01) and directly associated with LVEF (r = 0.71, P < 0.0001). Taken together, we conclude that patients who develop heart failure due to anthracycline-based chemotherapy have sympathetic neural overdrive and reduced exercise capacity. In addition, these physiological changes are similar to those observed in patients with HFrEF.NEW & NOTEWORTHY Patients with heart failure with reduced ejection fraction related to anthracycline-based chemotherapy have increased sympathetic nerve activity and decreased exercise capacity. These alterations in autonomic control and physical capacity are similar to those observed in patients with heart failure due to other etiologies. These findings highlight the importance of special care of oncological patients treated with chemotherapy.

[Duration of remote work and a positive diagnosis of COVID-19: an analysis of PNAD COVID19 data]. / Duração do trabalho remoto e diagnóstico positivo de COVID-19: análises dos dados da PNAD COVID19.

The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Duração do trabalho remoto e diagnóstico positivo de COVID-19: análises dos dados da PNAD COVID19 / Duration of remote work and a positive diagnosis of COVID-19: an analysis of PNAD COVID19 data

Resumo Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Abstract The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Complicações transfusionais em pacientes idosos hospitalizados: revisão integrativa da literatura / Complicaciones transfusionales en ancianos hospitalizados: revisión integrativa de la literatura / Transfusion complications in hospitalized elderly patients: integrative literature review

Objetivo: identificar as principais complicações ocasionadas pela transfusão sanguínea à saúde do idoso hospitalizado através da análise das evidências científicas. Método: revisão integrativa realizada com estudos em inglês provenientes de bases de dados nacionais e internacionais publicados no período de 2017 a 2021. Os principais descritores foram "Blood Transfusion", "Transfusion Reaction", "Aged" e "Hospitalization", combinados por meio dos operadores booleanos "AND" e "OR". Resultados: foram incluídos 23 estudos que retratavam as principais complicações da transfusão sanguínea para a pessoa idosa hospitalizada. As doze diferentes complicações foram alocadas em duas categorias: relacionadas a cirurgias ou complicações não-cirúrgicas. Maior tempo de permanência hospitalar, mortalidade, reações transfusionais, lesão renal aguda pós-operatória e delirium pós-operatório fizeram parte dos principais achados. Conclusão: os mecanismos pelos quais as complicações se desenvolvem ainda não estão totalmente esclarecidos, evidenciando a importância do estímulo à realização de novas pesquisas que envolvam esta temática.

Objective: to identify the main complications caused by blood transfusion to the health of the hospitalized elderly through the analysis of scientific evidence. Method: integrative review conducted with studies in English from national and international databases published in the period from 2017 to 2021. The main descriptors were "BloodTransfusion", "Transfusion Reaction", "Aged" and "Hospitalization", combined by means of the Boolean operators "AND" and "OR". Results: 23 studies were included that depicted the main complications of blood transfusion for the hospitalized elderly person. The twelve different complications were allocated into two categories: surgery-related or non-surgical complications. Longer hospital stay, mortality, transfusion reactions, postoperative acute kidney injury and postoperative delirium were among the mainachievements. Conclusion: the mechanisms by which complications develop are not yet fully understood, highlighting the importance of encouraging further research on this topic.

Objetivo: identificar las principales complicaciones ocasionadas por la transfusión sanguínea a la salud del idoso hospitalizado a través del análisis de las evidencias científicas. Método: revisión integradora realizada con estudios en inglés de bases de datos nacionales e internacionales publicados en el período 2017 a 2021. Los descriptores principales fueron "BloodTransfusion", "Transfusion Reaction", "Aged" y "Hospitalization", combinados mediante los operadores booleanos "AND" y "OR". Resultados:se incluyeron 23 estudios que retrataban las principales complicaciones de la transfusión sanguínea en el anciano hospitalizado. Las doce complicaciones diferentes se asignaron a dos categorías: complicaciones relacionadas con la cirugía o complicaciones no relacionadas con la cirugía. La prolongación de la estancia hospitalaria, la mortalidad, las reacciones transfusionales, la lesión renal aguda postoperatoria y el delirio postoperatorio formaron parte de las principales. Conclusión: los mecanismos por los que se desarrollan las complicaciones aún no se comprenden del todo, lo que pone de relieve la importancia de fomentar la investigación sobre este tema.

The trend of services provided by human milk banks between 2010 and 2019 in Brazil

Abstract Objective: To describe the trend of participation in group and individual support by human milk banks (HMBs) provided between 2010 and 2019 in Brazil. Methods: Ecological study with data from participation in group and individual support provided by the HMBs between 2010 and 2019, available in the production report of the Brazilian Network of Human Milk Banks. The number of participation in group and individual support was expressed for Brazil and for Brazilian macroregions in absolute numbers. Trend analysis was performed from the analysis of index numbers, considering the year 2010 as a reference. It was calculated the ratio of the number of participation in group and individual support by HMBs for each macroregion and year. Results: There was an increase of 42% in participation in group support (300,595 in 2010 vs 425,570 in 2019) and an increase of 69% in individual support (1,157,038 in 2010 vs 1,962,162 in 2019). The North and Northeast macroregions had the highest growth rates in the provision of these services (122 and 131%, respectively), above the national growth rate in the study period. In contrast, the Midwest region showed a downward trend throughout this period, for both types of support. However, in the Midwest, there was a higher ratio of participation in groups by HMBs between 2010 and 2016 and for individual support by HMBs between 2010 and 2012. Conclusion: Individual and group support provided by the HMB as a strategy to support breastfeeding increased considerably in Brazil during the study period, especially in the North and Northeast regions.

Atuação do Fonoaudiólogo na Gestão em Saúde Pública em um Estado do sul do Brasil

Objetivo: Documentar as atividades do fonoaudiólogo na gestão em saúde, apresentando o perfil dos profissionais e suas atribuições nos setores em que atuam. Métodos: Trata-se de um estudo transversal de investigação quantitativa e qualitativa, realizado através de um questionário virtual e autoaplicável. Resultados: Participaram do estudo 20 profissionais, todas do sexo feminino, a maioria na faixa etária entre 31 e 40 anos, com vínculo empregatício de concursada. A inserção das profissionais iniciou em 1998, concentrando-se nos anos de 2014 e 2015. A maior parte iniciou na Macrorregião Metropolitana, sem experiência prévia no âmbito da gestão em saúde pública. Quanto às atribuições das fonoaudiólogas no cargo de gestão em saúde, citaram a regulação de exames e consultas em especialidades, o trabalho interdisciplinar e intersetorial, a realização de educação em saúde para profissionais e usuários, a coordenação de políticas públicas em saúde, o planejamento e monitoramento das ações de saúde. A política pública citada com maior frequência foi a Saúde da Pessoa com Deficiência, especialmente, na área de Reabilitação Auditiva. Conclusões: Pode-se considerar que a presença deste profissional na equipe gestora é essencial para fomentar e trazer visibilidade para a Fonoaudiologia no âmbito da Saúde Pública.

The trend of services provided by human milk banks between 2010 and 2019 in Brazil.

OBJECTIVE: To describe the trend of participation in group and individual support by human milk banks (HMBs) provided between 2010 and 2019 in Brazil. METHODS: Ecological study with data from participation in group and individual support provided by the HMBs between 2010 and 2019, available in the production report of the Brazilian Network of Human Milk Banks. The number of participation in group and individual support was expressed for Brazil and for Brazilian macroregions in absolute numbers. Trend analysis was performed from the analysis of index numbers, considering the year 2010 as a reference. It was calculated the ratio of the number of participation in group and individual support by HMBs for each macroregion and year. RESULTS: There was an increase of 42% in participation in group support (300,595 in 2010 vs 425,570 in 2019) and an increase of 69% in individual support (1,157,038 in 2010 vs 1,962,162 in 2019). The North and Northeast macroregions had the highest growth rates in the provision of these services (122 and 131%, respectively), above the national growth rate in the study period. In contrast, the Midwest region showed a downward trend throughout this period, for both types of support. However, in the Midwest, there was a higher ratio of participation in groups by HMBs between 2010 and 2016 and for individual support by HMBs between 2010 and 2012. CONCLUSION: Individual and group support provided by the HMB as a strategy to support breastfeeding increased considerably in Brazil during the study period, especially in the North and Northeast regions.

Association Between Maternal Work and Exclusive Breastfeeding in Countries of Latin America and Caribbean.

OBJECTIVE: The aim of this study was to estimate the association between individual and contextual characteristics related to maternal work and exclusive breastfeeding (EBF) in Latin America and the Caribbean. METHODS: A cross-sectional study, conducted with data from the Demographic and Health Survey of Bolivia (2008), Brazil (2006), Colombia (2010), the Dominican Republic (2007), Guatemala (2015), Haiti (2017), Honduras (2011) and Peru (2011). The sample included infants who were under 6 months of age and their mothers. The outcome was EBF (yes/no), individual predictors were maternal employment status (employed/not employed), type of occupation, and type of employment (formal/informal), and contextual predictors were gross domestic product, maternity leave, and percentage of women in the labor force. The association between maternal employment status and EBF was performed using multilevel Poisson analysis adjusted for maternal education level, presence of partner, place of residence, maternal age, type of childbirth, primiparity, wealth index and breastfeeding in the first hour of life. RESULTS: The prevalence of EBF was 58.0% in Bolivia, 41.1% in Brazil, 39.2% in Colombia, 7.6% in the Dominican Republic, 50.8% in Guatemala, 39.7% in Haiti, 31.1% in Honduras, and 68.1% in Peru. The percentage of employed women ranged from 19.1% in the Dominican Republic to 46.1% in Bolivia. Maternal employment was negatively associated with EBF (Prevalence Ratio [PR] = 0.77; 95% CI 0.73, 0.82), while the highest percentage of women in the labor force of the country was positively associated with EBF (PR = 1.03; 95% CI 1.01, 1.06), with an increase in the PR value after the inclusion of gross domestic product in the model. CONCLUSIONS: The prevalence of EBF was lower in infants whose mothers were employed. However, the prevalence of EBF was higher in countries with a larger percentage of women in the labor force.

18F-FDG PET/CT in Late Acquisition Identifies Sites of Active Disease in Treated Takayasu Arteritis.

OBJECTIVE: Few studies have taken advantage of 18F-fluorodeoxyglucose positron emission tomography associated with computed tomography (18F-FDG PET/CT) to personalize patient evaluation and identify sites of more active disease in Takayasu arteritis (TA)-treated patients. This study aimed to evaluate the utility of 18F-FDG PET/CT in late acquisition in identifying sites of active disease in patients under full treatment for TA. METHODS: In this cross-sectional study, patients under full treatment underwent whole-body 18F-FDG PET/CT. Sites of increased 18F-FDG uptake were classified by a score of 3 on the visual scale using the liver uptake as reference. A quantitative analysis was also performed by measuring the maximum standardized uptake value (SUV) of the vascular wall of affected arteries. Disease activity using the National Institutes of Health criteria was also evaluated. RESULTS: Of the 20 patients, there were 18 female and 2 male patients, with a mean age of 43.6 (±11.58) years and a disease duration of 8.3 (±6.25) years. Thirteen participants (65%) were in inflammatory activity according to the criteria proposed by the National Institutes of Health. All patients received immunosuppressive agents, and one of them received immunobiological treatment. The highest SUV value was 6.2 in the aortic arch, and the lowest was 1.0 in the subclavian artery. The mean maximum SUV did not differ between clinically active and inactive patients. In the visual analysis, all participants had at least 1 vascular site with inflammatory activity, with an uptake ≥2 in relation to the liver. The aortic arch was the most frequently involved site. CONCLUSIONS: This study showed that 18F-FDG PET/CT in late acquisition is an effective imaging method to assess TA activity even in fully treated patients.

Horta comunitária e Psicologia Social: um relato de experiência / Community garden and social psychology: an experience report

A experiência profissional aqui relatada se refere à prática de estágio supervisionado em Psicologia Social e Comunitária, desenvolvida no ano de 2017, junto a um grupo intergeracional de horta comunitária. O trabalho foi realizado em uma instituição de assistência social de um município do interior do estado de São Paulo. Tendo por objetivo promover o desenvolvimento humano e fomentar a formação grupal entre seus participantes, as atividades práticas desenvolvidas na horta foram entendidas e organizadas como atividades-meio para a promoção do desenvolvimento e constituição grupal. O grupo intergeracional realizou ao longo do ano mais de trinta encontros semanais nos quais, além das atividades práticas na horta, também ocorreram rodas de conversa, discussão de curtas metragens, dinâmicas grupais, dentre outras. Destacamos como principais resultados desta intervenção entre os participantes do grupo: a aprendizagem de variadas técnicas de cultivo; o fortalecimento das relações interpessoais entre si; o desenvolvimento da autonomia e auto-organização do coletivo; e a constituição deste como importante rede de apoio para seus integrantes.(AU)

The professional experience reported refers to the practice of supervised internship in Social and Community Psychology, developed in 2017, with an intergenerational community garden group. The work was carried out in a social assistance institution in a municipality in the interior of the state of São Paulo. With the objective of promoting human development and fostering group formation among its participants, the practical activities developed in the garden were understood and organized as means-activities to promote group development and constitution. Over the course of the year, the intergenerational group held more than thirty weekly meetings in which, in addition to practical activities in the garden, there were also conversation circles, discussion of short films, group dynamics, among others. We highlight as main results of this intervention observed among the group members: the learning of various cultivation techniques; the strengthening of interpersonal relationships; the development of group autonomy and self-organization; and its constitution as an important support network for its members.(AU)

La experiencia profesional aquí relatada se refiere a la práctica de pasantía supervisada en Psicología Social y Comunitaria, desarrollada en 2017, con un grupo intergeneracional de huerta comunitaria. El trabajo fue realizado en una institución de asistencia social de un municipio del interior del estado de São Paulo. Con el objetivo de promover el desarrollo humano y promover la formación de grupos entre sus participantes, las actividades prácticas desarrolladas en el jardín fueron entendidas y organizadas como medios-actividades para la promoción del desarrollo y constitución de grupos. A lo largo del año, el grupo intergeneracional realizó más de treinta encuentros semanales en los que, además de actividades prácticas en el jardín, también hubo ruedas de conversación, discusión de cortometrajes, dinámicas de grupo, entre otros. Destacamos como principales resultados de esta intervención entre los participantes del grupo: el aprendizaje de diferentes técnicas de cultivo; el fortalecimiento de las relaciones interpersonales entre ellos; el desarrollo de la autonomía colectiva y la autoorganización; y su constitución como una importante red de apoyo para sus miembros.(AU)

Perfil epidemiológico dos casos notificados de sífilis materna e congênita em uma maternidade referência em Belo Horizonte / Epidemiological profile of the reported cases of maternal and congenital syphilis in a reference maternity hospital from Belo Horizonte

Introdução: A sífilis é uma doença infectocontagiosa causada pela bactéria Treponema pallidum, com transmissão predominantemente sexual. Nas gestantes não tratadas ou tratadas de forma inadequada, a infecção ocorre por via transplacentária. Objetivos: Traçar o perfil epidemiológico dos casos de sífilis materna e congênita. Métodos: Estudo transversal, descritivo e quantitativo realizado através do acesso aos casos notificados de sífilis no período de janeiro a junho de 2020, em uma maternidade referência em assistência materno-infantil em Belo Horizonte, Minas Gerais. Resultados: Foram identificados 232 casos notificados de sífilis congênita neste período e a prevalência da doença foi de 4,3%. Entre as gestantes, 69% possuem 20 a 34 anos, 14,65% ensino fundamental completo e 43,1% são de raça parda. Quanto aos casos de transmissão vertical, 87,5% realizaram pré-natal, 23,3% obtiveram diagnóstico de sífilis no momento do parto e em 15,1% houve tratamento concomitante do parceiro. Conclusão: Na maternidade estudada é elevada a prevalência da sífilis congênita. Os resultados demonstram a necessidade de melhoria no controle da sífilis na gestação.

Introduction: Syphilis is an infectious contagious disease caused by bacterium Treponema pallidum, with predominantly sexual transmission. In untreated or inadequately treated pregnant women, the infection occurs transplacentally. Purpose: To trace the epidemiological profile of the maternal and congenital syphilis cases. Methods: A cross-sectional, descriptive and quantitative study conducted through access to the syphilis cases reported from January to June 2020, in a maternity hospital that is a reference in maternal and childcare in Belo Horizonte, Minas Gerais. Results: A total of 232 reported cases of congenital syphilis were identified in this period and the prevalence of the disease was 4.3%. Among the pregnant women, 69% are aged between 20 and 34 years old, 14.65% have complete elementary school, and 43.1% are brown-skinned. As for the cases of vertical transmission, 87.5% attended prenatal care, 23.3% were diagnosed with syphilis at the time of delivery and, in 15.1% there was concomitant treatment of the partners. Conclusion: In the maternity hospital under study, the prevalence of congenital syphilis is high. The results show the need for improvement in the control of syphilis during pregnancy

Processo de passagem de plantão: o olhar de enfermeiras nas unidades de terapia intensiva / Procedimiento de paso de guardia: la mirada de las enfermeras en las unidades de cuidados intensivos / Procedure for the handover: nurses' perspective in intensive care units

Objetivo: compreender o processo de passagem de plantão das enfermeiras nas Unidades de Terapia Intensiva Adulto. Método: estudo com abordagem qualitativa, cuja coleta de dados foi realizada entre outubro e dezembro de 2020, por meio de observação não participativa e entrevista semiestruturada realizada em cinco unidades intensivas de hospital público do estado da Bahia, Brasil. Resultados: emergiram duas categorias principais: Práxis da passagem de plantão para melhoria do cuidado e Barreiras que prejudicam a comunicação durante a passagem de plantão. Foi possível compreender o processo de passagem de plantão, com base nos olhares das enfermeiras intensivistas, as quais dispõem de elementos estruturais para comunicação efetiva que reverberam na continuidade da assistência. Considerações finais: no processo de passagem de plantão das enfermeiras, condições estruturais e ambientais, tais como conversas paralelas, dispersão, falta de atenção, interrupções, saídas antecipadas e ruídos foram caracterizadas como barreiras que causavam falhas e interferiam no processo de comunicação.

Objetivo: comprender el proceso de paso de guardia de las enfermeras en las Unidades de Terapia Intensiva Adulto. Método: estudio con enfoque cualitativo, cuya recopilación de datos fue realizada entre octubre y diciembre de 2020, por medio de observación no participativa y entrevista semiestructurada realizada en cinco unidades intensivas de hospital público del estado de Bahía, Brasil. Resultados: surgieron dos categorías principales: Praxis del paso de guardia para mejora del cuidado y Barreras que perjudican la comunicación durante el paso de guardia. Fue posible comprender el proceso de paso de guardia, con base en las miradas de las enfermeras intensivistas, las cuales disponen de elementos estructurales para comunicación efectiva que reverberan en la continuidad de la asistencia. Consideraciones finales: en el proceso de paso de guardia de las enfermeras, condiciones estructurales y ambientales, tales como conversaciones paralelas, dispersión, falta de atención, Las interrupciones, salidas anticipadas y ruidos fueron caracterizadas como barreras que causaban fallas e interferían en el proceso de comunicación.

Objective: to understand the process of handover of nurses in Adult Intensive Care Units. Method: study with a qualitative approach, whose data collection was performed between October and December 2020, through non-participant observation and semi-structured interview conducted in five intensive care units of a public hospital in the state of Bahia, Brazil. Results: two main categories emerged: Praxis of the handover to improve care and barriers that impair communication during the handover. It was possible to understand the process of shift, based on the looks of intensive nurses, which have structural elements for effective communication that reverberate in the continuity of care. Final considerations: in the process of handover of nurses, structural and environmental conditions, such as parallel conversations, dispersion, lack of attention, interruptions, anticipated egress and noise were characterized as barriers that caused failures and interfered in the communication process.

Recommendations for the management of cardiovascular risk in patients with chronic myeloid leukemia on tyrosine kinase inhibitors: risk assessment, stratification, treatment and monitoring

ABSTRACT This manuscript summarizes the results of the consensus meeting composed of hematologists and cardiologists to establish recommendations for the prevention and follow-up of cardiovascular (CV) risk in patients with chronic myeloid leukemia (CML) treated with BCR-ABL tyrosine kinase inhibitors (TKIs) from the point of view of clinical practice and from the perspective of hematology consultation.In the first medical appointment, the CV risk factors should be identified to perform the baseline risk stratification, based on the Brazilian Guideline of Dyslipidemia and Atherosclerosis Prevention Update (risk levels: very high, high, intermediate and low).Once stratified, the treatment of the CV risk factors should be administered. If the patient presents risk factors, such as hypertension, diabetes, renal disease, smoking and hypercholesterolemia, the evaluation and initial treatment may be done by the hematologist, being an option the request for evaluation by a specialist. If the patient has a history of previous CV disease, we recommend referral to a specialist. As the CV risk score is dynamic and the control of risk factors can reduce the patient risk, this expert consensus recommends that the re-evaluation of the CV risk after the baseline should be performed at 3 months, 6 months and 12 months. After this period, it should be done annually and, for specific patients, at the clinician's discretion.The evaluation of the baseline CV risk and the safe administration of a TKI allow the patient to benefit from the maximum treatment, avoiding unwanted effects.

Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides.

N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides are converted into natural product inspired scaffolds via iridium photocatalyzed intramolecular [2+2] photocycloaddition. The protocol has a broad substrate scope, whilst operating under mild reaction conditions. Tethering four components forming a trisubstituted cyclobutane core builds rapidly high molecular complexity. Our approach allows the design and synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones, in yields ranging between 20-99 %, and with excellent regio- and diastereoselectivity. Moreover, it was demonstrated that the intramolecular [2+2]-cycloaddition of 1,7-enynes-after fragmentation of the cyclobutane ring-leads to enyne-metathesis-like products.

Recommendations for the management of cardiovascular risk in patients with chronic myeloid leukemia on tyrosine kinase inhibitors: risk assessment, stratification, treatment and monitoring.

This manuscript summarizes the results of the consensus meeting composed of hematologists and cardiologists to establish recommendations for the prevention and follow-up of cardiovascular (CV) risk in patients with chronic myeloid leukemia (CML) treated with BCR-ABL tyrosine kinase inhibitors (TKIs) from the point of view of clinical practice and from the perspective of hematology consultation. In the first medical appointment, the CV risk factors should be identified to perform the baseline risk stratification, based on the Brazilian Guideline of Dyslipidemia and Atherosclerosis Prevention Update (risk levels: very high, high, intermediate and low). Once stratified, the treatment of the CV risk factors should be administered. If the patient presents risk factors, such as hypertension, diabetes, renal disease, smoking and hypercholesterolemia, the evaluation and initial treatment may be done by the hematologist, being an option the request for evaluation by a specialist. If the patient has a history of previous CV disease, we recommend referral to a specialist. As the CV risk score is dynamic and the control of risk factors can reduce the patient risk, this expert consensus recommends that the re-evaluation of the CV risk after the baseline should be performed at 3 months, 6 months and 12 months. After this period, it should be done annually and, for specific patients, at the clinician's discretion. The evaluation of the baseline CV risk and the safe administration of a TKI allow the patient to benefit from the maximum treatment, avoiding unwanted effects.

Green Approach for Visible-Light-Induced Direct Functionalization of 2-Methylquinolines.

A transition metal- and oxidant-free visible light-photoinduced protocol for direct functionalization of 2-methylquinolines has been developed. This protocol enabled the C-H functionalization of substituted 2-methylquinolines with diacetyl or ethyl pyruvate, under environmentally friendly conditions. A mechanistic investigation based on density functional theory (DFT) calculations provided details about the origins of reactivity and selectivity.

Photoredox Catalysis toward 2-Sulfenylindole Synthesis through a Radical Cascade Process.

A radical cascade process initiated through visible-light induced thiyl radical coupling with ortho-substituted arylisocianides followed by an intramolecular cyclization and subsequent aromatization to access 2-sulfenylindoles is described. The key thiyl radicals are promptly generated via a hydrogen atom transfer event. The redox-neutral protocol features broad substrate scope, excellent functional group tolerance, and mild reaction conditions. Furthermore, the implementation of a continuous flow variant allows smooth scalability with a short residence time through process intensification.

Comportamentos dos profissionais de enfermagem na efetivação da humanização hospitalar / Behavior of nursing professionals on the effectiveness of hospital humanization / Comportamientos de los profesionales de enfermería en la efectividad de la humanización hospitalaria

Objetivo: identificar os comportamentos dos profissionais de enfermagem que favorecem a efetivação da humanização hospitalar. Método: trata-se de uma revisão integrativa da literatura realizada através das bases de dados SciELO, LILACS, IBECS, MEDLINE e Biblioteca Cochrane. A busca foi realizada em outubro de 2018, possuindo como amostra final 20 artigos. Resultados: observou-se, após leitura na íntegra, a delimitação de 3 eixos temáticos quanto ao empoderamento profissional; acolhimento em âmbito hospitalar; e Comunicação e inter-relação no ambiente hospitalar, sendo indicadas significativamente nos estudos que norteiam o assunto. Conclusão: revelou-se que o enfermeiro desenvolve funções de gerenciamento, assistência direta ao paciente e manipulação da tecnologia utilizada em ambientes especializados. Tais atribuições propiciam a sobrecarga do profissional além do distanciamento da assistência humanizada

Objective: identify the behaviors of nursing professionals that favor the implementation of hospital humanization. Method: this is an integrative review of the literature using the SciELO, LILACS, IBECS, MEDLINE and Cochrane Library databases. The search was performed in October 2018, having as final sample 20 articles. Results: it was observed, after reading in full, the delimitation of 3 thematic axes regarding professional empowerment; hospital reception; and Communication and interrelationship in the hospital environment, being indicated significantly in the studies that guide the subject. Conclusion: it was revealed that nurses develop management functions, direct patient care and manipulation of technology used in specialized environments. Such attributions allow the professional overload and the distancing of humanized assistance

Objetivo: identificar los comportamientos de los profesionales de enfermería que favorecen la implementación de la humanización hospitalaria. Método: se trata de una revisión integrativa de la literatura realizada a través de las bases de datos SciELO, LILACS, IBECS, MEDLINE y Biblioteca Cochrane. La búsqueda fue realizada en octubre de 2018, teniendo como muestra final 20 artículos. Resultados: si se observa, después de leer en su totalidad, la delimitación de 3 partes temáticas relativas al empoderamiento profesional; recepción hospitalaria; y Comunicación e interrelación en el entorno hospitalario, indicándose de manera significativa en los estudios que orientan el tema. Conclusión: se reveló que las enfermeras desarrollan funciones de gestión, atención directa al paciente y manipulación de la tecnología utilizada en entornos especializados. Tales atribuciones permiten la sobrecarga profesional y el distanciamiento de la asistencia humanizada

Accuracy and Psychometric Properties of the Brazilian Version of the Montreal Cognitive Assessment as a Brief Screening Tool for Mild Cognitive Impairment and Alzheimer's Disease in the Initial Stages in the Elderly.

OBJECTIVE: To evaluate the applicability and the psychometric properties of Montreal Cognitive Assessment Brazilian Version (MoCA-BR) in the elderly, as well as comparing its accuracy as a tracking test for mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) with the accuracy of Mini-Mental State Examination (MMSE). METHOD: A transversal study was performed in 4 reference medical centers that care for the elderly. In all, 229 elderly participated in the study. To select the sample, the clinical history of the elderly, Pfeffer Functional Activities Questionnaire, and neuropsychological battery, apart from MMSE and MoCA-BR cognitive tests, were selected. The elderly were classified into control, MCI, and mild AD groups. RESULTS: There was a significant statistical difference between the MoCA-BR scores of the elderly and the control group, MCI, and mild AD (p < 0.001). The Cronbach alpha for MoCA-BR was 0.77, indicating a good internal consistency. The test-retest reliability was elevated, with intraclass correlation coefficient (ICC) 0.91. The inter-examiner reliability was excellent (ICC 0.96). The area under curve of the receiver operating characteristics curve was 0.95, when evaluating the ability of MoCA-BR to discriminate between the elderly with cognitive impairment and cognitively healthy elderly. CONCLUSIONS: The results of the study show that the Brazilian version of MoCA is a reliable cognitive tracking tool and is accurate for the detection of MCI and early stage AD, with good applicability on the elderly with education equal to or more than 4 years and adequate to discriminate between cognitively healthy elderly, and those with MCI and mild, proving to be superior to MMSE in tracking MCI and similar to this test when tracking mild AD.