Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives.

In this work, 13 thiosemicarbazones (1a - m) and 16 thiazoles (2a - p) were obtained, which were properly characterized by spectroscopic and spectrometric techniques. The pharmacokinetic properties obtained in silico revealed that the derivatives are in accordance with the parameters established by lipinski and veber, showing that such compounds have good bioavailability or permeability when administered orally. In assays of antioxidant activity, thiosemicarbazones showed moderate to high antioxidant potential when compared to thiazoles. In addition, they were able to interact with albumin and DNA. Screening assays to assess the toxicity of compounds to mammalian cells revealed that thiosemicarbazones were less toxic when compared to thiazoles. In relation to in vitro antiparasitic activity, thiosemicarbazones and thiazoles showed cytotoxic potential against the parasites Leishmania amazonensis and Trypanosoma cruzi. Among the compounds, 1b, 1j and 2l stood out, showing inhibition potential for the amastigote forms of the two parasites. As for the in vitro antimalarial activity, thiosemicarbazones did not inhibit Plasmodium falciparum growth. In contrast, thiazoles promoted growth inhibition. This study shows in a preliminary way that the synthesized compounds have antiparasitic potential in vitro.

Thermoplastic starch nanocomposites: sources, production and applications - a review.

The development of materials based on thermoplastic starch (TPS) is an excellent alternative to replace or reduce the use of petroleum-derived polymers. The abundance, renewable origin, biodegradability, biocompatibility, and low cost of starch are among the advantages related to the application of TPS compared to other thermoplastic biopolymers. However, through the literature review, it was possible to observe the need to improve some properties, to allow TPS to replace commonly used polyolefins. The studies reviewed achieved these modifications were achieved by using plasticizers, adjusting processing conditions, and incorporating fillers. In this sense, the addition of nanofillers proved to be the main modification strategy due to the large number of available nanofillers and the low charge concentration required for such improvement. The improvement can be seen in thermal, mechanical, electrical, optical, magnetic, antimicrobial, barrier, biocompatibility, cytotoxicity, solubility, and swelling properties. These modification strategies, the reviewed studies described the development of a wide range of materials. These are products with great potential for targeting different applications. Thus, this review addresses a wide range of essential aspects in developing of this type of nanocomposite. Covering from starch sources, processing routes, characterization methods, the properties of the obtained nanocomposites, to the various applications. Therefore, this review will provide an overview for everyone interested in working with TPS nanocomposites. Through a comprehensive review of the subject, which in most studies is done in a way directed to a specific area of study.

Validation and description of two new north-western Australian Rainbow skinks with multispecies coalescent methods and morphology.

While methods for genetic species delimitation have noticeably improved in the last decade, this remains a work in progress. Ideally, model based approaches should be applied and considered jointly with other lines of evidence, primarily morphology and geography, in an integrative taxonomy framework. Deep phylogeographic divergences have been reported for several species of Carlia skinks, but only for some eastern taxa have species boundaries been formally tested. The present study does this and revises the taxonomy for two species from northern Australia, Carlia johnstonei and C. triacantha. We introduce an approach that is based on the recently published method StarBEAST2, which uses multilocus data to explore the support for alternative species delimitation hypotheses using Bayes Factors (BFD). We apply this method, jointly with two other multispecies coalescent methods, using an extensive (from 2,163 exons) data set along with measures of 11 morphological characters. We use this integrated approach to evaluate two new candidate species previously revealed in phylogeographic analyses of rainbow skinks (genus Carlia) in Western Australia. The results based on BFD StarBEAST2, BFD* SNAPP and BPP genetic delimitation, together with morphology, support each of the four recently identified Carlia lineages as separate species. The BFD StarBEAST2 approach yielded results highly congruent with those from BFD* SNAPP and BPP. This supports use of the robust multilocus multispecies coalescent StarBEAST2 method for species delimitation, which does not require a priori resolved species or gene trees. Compared to the situation in C. triacantha, morphological divergence was greater between the two lineages within Kimberley endemic C. johnstonei, which also had deeper divergent histories. This congruence supports recognition of two species within C. johnstonei. Nevertheless, the combined evidence also supports recognition of two taxa within the more widespread C. triacantha. With this work, we describe two new species, Carlia insularis sp. nov and Carlia isostriacantha sp. nov. in the northwest of Australia. This contributes to increasing recognition that this region of tropical Australia has a rich and unique fauna.

Efetividade da hidroterapia e da cinesioterapia na reabilitação de idosos com histórico de quedas / Effectiveness of hydrotherapy and kinesiotherapy in elderly patients with history of falls

A fisioterapia tem um papel fundamental na reabilitação funcional de idosos com histórico de quedas. O objetivo deste estudo foi avaliar a efetividade do protocolo de hidroterapia e cinesioterapia no equilíbrio, na agilidade e na estatura em idosos que costumam cair. Foram avaliados 14 idosos por meio de estadiômetro, escala de equilíbrio de Berg e Timed Up & Go. Os idosos foram alocados em dois grupos: G1, tratados com hidroterapia, e G2, tratados com cinesioterapia. O protocolo teve duração de 2 meses, sendo duas vezes por semana e sessões de 40 minutos, totalizando 16 atendimentos. Após 16 sessões, os participantes foram reavaliados. Os dados foram analisados estatisticamente pelos testes Kruskal-Wallis e Wilcox-Mann-Whitney. Comparando-se os dois grupos, verificou-se que ambos os grupos apresentaram maior pontuação na escala de equilíbrio de Berg, menor tempo na realização do Timed Up & Go e uma tendência a significância na estatura corporal após a aplicação do protocolo No entanto, não houve diferenças estatisticamente entre os grupos. Pode-se concluir que a hidroterapia e a cinesioterapia são efetivas para a melhora do equilíbrio e agilidade dos participantes, amenizando o declínio da capacidade funcional inerente ao envelhecimento.

The functional rehabilitation of elderly fallers is an objective of physicaltherapy. The aim of this study was to evaluate the effectiveness ofhydrotherapy and kinesiotherapy protocols in balance, agility andheight in falling elder ones. We evaluated 14 elderly patients withhistory of falls. The outcome measures were the Berg Balance Scalescore, Timed up & go and height. The participants were randomlydivided in two groups: G1, treated with hydrotherapy, G2 treatedwith kinesiotherapy. The experimental intervention was a 40-minutesession per day, 2 days per week for 2 months. Data were statisticallyanalyzed by the Kruskal-Wallis and Mann-Whitney-Wilcoxtests. Comparing the two groups, it was found that both groupsincreased Berg Balance Scale and decreased Timed Up & Goand there is a significance in stature after the implementation of theprotocol. However, there were no statistical differences between thetwo groups. In conclusion, this study suggests hydrotherapy andkinesiotherapy are effective for improving balance and agility in thesample of participants, reducing the decline in functional capacityinherent to the aging.

Efetividade da hidroterapia e da cinesioterapia na reabilitação de idosos com histórico de quedas / Effectiveness of hydrotherapy and kinesiotherapy in elderly patients with history of falls

A fisioterapia tem um papel fundamental na reabilitação funcional de idosos com histórico de quedas. O objetivo deste estudo foi avaliar a efetividade do protocolo de hidroterapia e cinesioterapia no equilíbrio, na agilidade e na estatura em idosos que costumam cair. Foram avaliados 14 idosos por meio de estadiômetro, escala de equilíbrio de Berg e Timed Up & Go. Os idosos foram alocados em dois grupos: G1, tratados com hidroterapia, e G2, tratados com cinesioterapia. O protocolo teve duração de 2 meses, sendo duas vezes por semana e sessões de 40 minutos, totalizando 16 atendimentos. Após 16 sessões, os participantes foram reavaliados. Os dados foram analisados estatisticamente pelos testes Kruskal-Wallis e Wilcox-Mann-Whitney. Comparando-se os dois grupos, verificou-se que ambos os grupos apresentaram maior pontuação na escala de equilíbrio de Berg, menor tempo na realização do Timed Up & Go e uma tendência a significância na estatura corporal após a aplicação do protocolo No entanto, não houve diferenças estatisticamente entre os grupos. Pode-se concluir que a hidroterapia e a cinesioterapia são efetivas para a melhora do equilíbrio e agilidade dos participantes, amenizando o declínio da capacidade funcional inerente ao envelhecimento. (AU)

Effectiveness of hydrotherapy and kinesiotherapy in elderly patients with history of falls The functional rehabilitation of elderly fallers is an objective of physical therapy. The aim of this study was to evaluate the effectiveness of hydrotherapy and kinesiotherapy protocols in balance, agility and height in falling elder ones. We evaluated 14 elderly patients with history of falls. The outcome measures were the Berg Balance Scale score, Timed up & go and height. The participants were randomly divided in two groups: G1, treated with hydrotherapy, G2 treated with kinesiotherapy. The experimental intervention was a 40-minute session per day, 2 days per week for 2 months. Data were statistically analyzed by the Kruskal-Wallis and Mann-Whitney-Wilcox tests. Comparing the two groups, it was found that both groups increased Berg Balance Scale and decreased Timed Up & Go and there is a significance in stature after the implementation of the protocol. However, there were no statistical differences between the two groups. In conclusion, this study suggests hydrotherapy and kinesiotherapy are effective for improving balance and agility in the sample of participants, reducing the decline in functional capacity inherent to the aging.(AU)

Interconsulta psicológica: demanda e assistência em hospital geral / Consultation-liaison psychology: demand and assistance in general hospital / Interconsulta psicológica: demanda y asistencia en hospital general

A interconsulta psicológica no hospital geral representa uma modalidade de atendimento clínico e um instrumento metodológico utilizado pelo psicólogo na assistência ao paciente internado, mediante solicitação de outros profissionais da saúde. O estudo objetivou caracterizar a demanda da interconsulta psicológica em um hospital geral, a partir da análise dos registros de solicitação de atendimento. Cento e sete pacientes foram atendidos entre janeiro e junho de 2010, dos quais 53 por cento eram do sexo masculino e 57 por cento eram adultos acima de 45 anos. A maioria das solicitações foi realizada por médicos (44 por cento) e enfermeiros (38 por cento), formalmente (59 por cento), e mediante contato prévio entre interconsultor e solicitante (85 por cento). Os principais motivos alegados para a solicitação da interconsulta foram sintomas psicológicos relacionados ao adoecimento (43 por cento) e identificação de comprometimento na adaptação do paciente à hospitalização (41 por cento). O modelo de interconsulta psicológica adotado no contexto estudado foi adequado, havendo engajamento da equipe multiprofissional na efetivação da prática.(AU)

The consultation-liaison psychology in general hospitals represents a modality of clinical and a methodological tool used by psychologists in inpatient care, upon the request of other health professionals. The study aimed to characterize the psychological demands of the liaison in a general hospital, from the analysis of attendance records request. One hundred and seven patients were treated between January and June 2010, in which 53 percent of the participants were male and 57 percent of adults over 45 years. Most requests were performed by physicians (44 percent) and nurses (38 percent), formally (59 percent), and previous contact between interconsultor and the applicant (85 percent). The main reasons given for the request liaison were: psychological symptoms related to illness (43 percent) and identification of impairment in the patient's adaptation to hospitalization (41 percent). The psychological liaison model adopted was appropriate to the studied context, with engagement of the multidisciplinary team in the effectiveness of practice.(AU)

La interconsulta psicológica en los hospitals generales representan una modalidad de clínica y una herramienta metodológica utilizada por los psicólogos en la atención hospitalaria del paciente, a petición de los profesionales de la salud. El objetivo del estudio fue caracterizar la demanda psicológica para referirlo a un hospital general, desde el análisis del servicio de solicitud de registros. Ciento siete pacientes fueron tratados entre enero y junio de 2010, siendo 53 por ciento hombres y 57 por ciento de los adultos mayores de 45 años. La mayoría de las solicitudes fueron realizadas por los médicos (44 por ciento) y enfermeras (38 por ciento), de manera formal (59 por ciento) y el contacto previo entre interconsultor y su interés (85 por ciento). Las razones principales de la solicitud de remisión fueron: síntomas psicológicos relacionados con la enfermedad (43 por ciento) y la identificación de la deficiencia en la adaptación del paciente a la hospitalización (41 por ciento). El modelo adoptado referencia psicológica era apropiado en el contexto estudiado, con la participación del equipo multidisciplinario en la efectividad de la práctica.(AU)

Interconsulta psicológica: demanda e assistência em hospital geral / Consultation-liaison psychology: demand and assistance in general hospital / Interconsulta psicológica: demanda y asistencia en hospital general

A interconsulta psicológica no hospital geral representa uma modalidade de atendimento clínico e um instrumento metodológico utilizado pelo psicólogo na assistência ao paciente internado, mediante solicitação de outros profissionais da saúde. O estudo objetivou caracterizar a demanda da interconsulta psicológica em um hospital geral, a partir da análise dos registros de solicitação de atendimento. Cento e sete pacientes foram atendidos entre janeiro e junho de 2010, dos quais 53 por cento eram do sexo masculino e 57 por cento eram adultos acima de 45 anos. A maioria das solicitações foi realizada por médicos (44 por cento) e enfermeiros (38 por cento), formalmente (59 por cento), e mediante contato prévio entre interconsultor e solicitante (85 por cento). Os principais motivos alegados para a solicitação da interconsulta foram sintomas psicológicos relacionados ao adoecimento (43 por cento) e identificação de comprometimento na adaptação do paciente à hospitalização (41 por cento). O modelo de interconsulta psicológica adotado no contexto estudado foi adequado, havendo engajamento da equipe multiprofissional na efetivação da prática.

The consultation-liaison psychology in general hospitals represents a modality of clinical and a methodological tool used by psychologists in inpatient care, upon the request of other health professionals. The study aimed to characterize the psychological demands of the liaison in a general hospital, from the analysis of attendance records request. One hundred and seven patients were treated between January and June 2010, in which 53 percent of the participants were male and 57 percent of adults over 45 years. Most requests were performed by physicians (44 percent) and nurses (38 percent), formally (59 percent), and previous contact between interconsultor and the applicant (85 percent). The main reasons given for the request liaison were: psychological symptoms related to illness (43 percent) and identification of impairment in the patient's adaptation to hospitalization (41 percent). The psychological liaison model adopted was appropriate to the studied context, with engagement of the multidisciplinary team in the effectiveness of practice.

La interconsulta psicológica en los hospitals generales representan una modalidad de clínica y una herramienta metodológica utilizada por los psicólogos en la atención hospitalaria del paciente, a petición de los profesionales de la salud. El objetivo del estudio fue caracterizar la demanda psicológica para referirlo a un hospital general, desde el análisis del servicio de solicitud de registros. Ciento siete pacientes fueron tratados entre enero y junio de 2010, siendo 53 por ciento hombres y 57 por ciento de los adultos mayores de 45 años. La mayoría de las solicitudes fueron realizadas por los médicos (44 por ciento) y enfermeras (38 por ciento), de manera formal (59 por ciento) y el contacto previo entre interconsultor y su interés (85 por ciento). Las razones principales de la solicitud de remisión fueron: síntomas psicológicos relacionados con la enfermedad (43 por ciento) y la identificación de la deficiencia en la adaptación del paciente a la hospitalización (41 por ciento). El modelo adoptado referencia psicológica era apropiado en el contexto estudiado, con la participación del equipo multidisciplinario en la efectividad de la práctica.