Subject(s)
Mediastinal Neoplasms/genetics , Mutation , Paraganglioma, Extra-Adrenal/genetics , Succinate Dehydrogenase/genetics , Female , Genetic Predisposition to Disease , Heredity , Humans , Mediastinal Neoplasms/diagnostic imaging , Mediastinal Neoplasms/pathology , Mediastinal Neoplasms/surgery , Middle Aged , Paraganglioma, Extra-Adrenal/diagnostic imaging , Paraganglioma, Extra-Adrenal/pathology , Paraganglioma, Extra-Adrenal/surgery , Pedigree , Sternotomy , Treatment OutcomeSubject(s)
Adenocarcinoma in Situ/complications , Adenocarcinoma of Lung/complications , Cystic Adenomatoid Malformation of Lung, Congenital/complications , Lung Neoplasms/complications , Adenocarcinoma in Situ/genetics , Adenocarcinoma in Situ/pathology , Adenocarcinoma in Situ/surgery , Adenocarcinoma of Lung/genetics , Adenocarcinoma of Lung/pathology , Adenocarcinoma of Lung/surgery , Adult , Biomarkers, Tumor/genetics , Cystic Adenomatoid Malformation of Lung, Congenital/diagnosis , Humans , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Male , Mutation, Missense , Pneumonectomy , Proto-Oncogene Proteins p21(ras)/genetics , Treatment OutcomeABSTRACT
Rosai-Dorfman disease or sinus histiocytosis is a nonmalignant disease chiefly presenting as a painless cervical lymphadenopathy, although extranodal involvement is also frequent. Involvement of the tracheobronchial tree is extremely rare, and there are no clear guidelines on management. Rosai-Dorfman disease usually presents as a tracheal tumor, although it may also present with extraluminal compression. Only 12 cases have been reported in the English language literature. Histopathology is required to confirm the diagnosis. We describe what we think is India's first reported case of histologically proven tracheal Rosai-Dorfman disease in a 40-year-old otherwise healthy lady.
Subject(s)
Histiocytes/pathology , Histiocytosis, Sinus/pathology , Tracheal Diseases/pathology , Adult , Biomarkers/analysis , Biopsy , Bronchoscopy , Female , Histiocytes/chemistry , Histiocytosis, Sinus/diagnostic imaging , Histiocytosis, Sinus/surgery , Humans , Immunohistochemistry , S100 Proteins/analysis , Tracheal Diseases/diagnostic imaging , Tracheal Diseases/surgery , Treatment OutcomeABSTRACT
Pulmonary dirofilariasis, caused by Dirofilaria immitis, rarely affects humans and is usually asymptomatic, but may present as chest pain, cough, hemoptysis, wheezing, low-grade fever, and malaise. The dead and dying worms obstruct branches of the pulmonary artery, causing infarction and a granulomatous reaction. Coin lesions are apparent on radiography, raising concern of malignancy. Complete surgical excision is the treatment of choice and an anthelmintic can be administered if residual lesions are present or the patient is from an endemic area. We present two cases of pulmonary dirofilariasis presenting as coin lesions in the lung, which were clinically suggestive of malignancy.