[The effect of polikatan on the ototoxic action of kanamycin]. / Vliianie polikatana na ototoksicheskoe deistvie kanamitsina.

Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.

[Clinical and experimental rationale of policatan administration in upper respiratory tract inflammation]. / Kliniko-éksperimental'noe obosnovanie primenenie polikatana pri vospalitel'nykh zabolevaniiakh verkhikh dykhatel'nykh putei.

Experimental and clinical trials of policatan in ENT inflammation have established that maximal antiinflammatory effect of the drug manifests in experimental serotonin, histamine and corragenin edema, less pronounced--in formaline-induced edema. The drug accelerated healing of infected burn ulcer in rabbit nose by 37%. This may be explained not only antiinflammatory effect of policatan, but also by stimulation of macrophage phagocytosis and bacteriostatic potential. Policatan proved effective in acute and chronic maxillary sinusitis, chronic frontal sinusitis and rhinitis, chronic hyperplastic maxilloethmoiditis. The drug reduced contamination with pathogenic and opportunistic microflora and reestablished saprophyte microflora.