From terminal ileum to terminal diagnosis: The critical role of terminal ileum intubation in diagnosing langerhans cell histiocytosis in a patient with TAR syndrome.

The co-occurrence of Thrombocytopenia with Absent Radius (TAR) syndrome and Langerhans Cell Histiocytosis (LCH) is exceedingly rare, with scant documentation in existing medical literature. This case report aims to shed light on this unique intersection of conditions, emphasizing the diagnostic and therapeutic challenges it presents. A 27-year-old female with a history of TAR syndrome presented with microcytic anemia, hip pain, and gastrointestinal symptoms. Terminal ileum intubation during colonoscopy revealed superficial ulcerations, leading to a biopsy that confirmed LCH. Subsequent radiologic investigations, including CT and MRI, showed multiple osseous lesions in the pelvis, sacrum, and skull. A treatment plan involving IV Cytarabine was initiated due to concerns of CNS involvement, as indicated by mastoid air cell involvement and symptoms of dizziness and ear fullness. The case highlights the diagnostic value of terminal ileum intubation during colonoscopy, which was pivotal in diagnosing LCH in this patient. It also discusses the use of IV cytarabine, a chemotherapy drug that inhibits DNA synthesis, as a suitable treatment option given the suspected CNS involvement. The case adds to the limited literature on the natural history and management of adult patients with LCH, particularly in the context of TAR syndrome. This case report serves as a compelling addition to medical literature, highlighting the diagnostic complexities and treatment considerations in a patient with both TAR syndrome and LCH. It emphasizes the importance of comprehensive diagnostic approaches, including terminal ileum intubation during colonoscopy, and introduces IV cytarabine as a viable treatment option for cases with suspected CNS involvement.

A global long-term daily reanalysis of reference evapotranspiration for drought and food-security monitoring.

NOAA has developed a global reference evapotranspiration (ET0) reanalysis using the UN Food and Agriculture Organization formulation (FAO-56) of the Penman-Monteith equation forced by MERRA phase 2 (MERRA2) meteorological and radiative drivers. The NOAA ET0 reanalysis is provided daily from January 1, 1980 to the near-present at a resolution of 0.5° latitude × 0.625° longitude. The reanalysis is verified against station data across southern Africa, a region presenting both significant challenges regarding hydroclimatic variability and observational quantity and quality and significant potential benefits to food-insecure populations. These data are generated from observations from the Southern African Science Service Centre for Climate Change and Adaptive Land Management (SASSCAL) network. We further verified globally against spatially distributed ET0 derived from two reanalyses-the Global Data Assimilation System (GDAS) and Princeton Global Forcing (PGF)-and these verifications produced similar results, yet demonstrated wide regional and seasonal differences. We also present cases that verify the operational applicability of the reanalysis in long-established drought, famine, crop- and pastoral-stress metrics, and in predictability assessments of drought forecasts.

Un análisis retrospectivo del manejo de la pandemia de Covid-19 en Guayaquil y Quito, Ecuador / A retrospective cross-sectional analysis of the management of the covid-19 pandemic in Guayaquil and Quito, Ecuador / Uma análise retrospectiva do manejo da pandemia de covid-19 em Guaiaquil e Quito, Equador

Las especies virales de la familia Coronaviridae presentan transmisión zoonótica y causan infecciones respiratorias y gastrointestinales en aves y mamíferos. En esta familia existen tres especies que han podido infectar diversas poblaciones humanas: SARS-CoV-1, MERS-CoV y SARS-CoV-2. Este último virus es el agente causal de la enfermedad denominada Covid-19, declarada por la Organización Mundial de la Salud como pandemia debido a su forma de transmisión, periodo de latencia y reportes en todo el mundo. En Ecuador, el primer caso de Covid-19 fue diagnosticado el 28 de febrero de 2020 y las medidas sanitarias fueron focalizadas en la suspensión de eventos masivos de forma local. Varios días después, el aislamiento empezó con el decreto del Estado de Emergencia Sanitaria en el que el gobierno central y el municipio de Quito innovaron en medidas de contingencia y prevención. Acto seguido, la imposición de cuarentena y toque de queda nacional inició con la declaración del Estado de Excepción, pero el municipio de Guayaquil no pudo manejar la contumacia ciudadana. Producto de ello, Guayaquil reportó un crecimiento exorbitante de defunciones en hospitales, viviendas y calles de la urbe. Por otra parte, el modelo de gestión establecido en Quito minimizó el impacto de la nueva enfermedad.

Viral species of the Coronaviridae family present zoonotic transmission and cause respiratory and gastrointestinal infections in birds and mammals. Three species of this family managed to infect several human populations: SARS-CoV-1, MERS-CoV and SARS-CoV-2. This last virus is the causative agent of the disease called covid-19, declared by the World Health Organization as a pandemic due to its mode of transmission, latency period and reports around the world. In Ecuador, the first case of covid-19 was diagnosed on February 28, 2020 and health measures have focused on suspending massive events locally. Several days later, isolation began with the decree of a State of Health Emergency in which the central government and the Municipality of Quito innovated in contingency and prevention measures. Immediately af terwards, the imposition of the quarantine and the national curfew began with the declaration of the State of Exception, but the municipality of Guayaquil was not able to face the citizen's contumacy. As a result, Guayaquil saw an exorbitant increase in deaths in hospitals, homes and city streets. On the other hand, the management model established in Quito minimized the impact of the new disease.

Espécies virais da família Coronaviridae apresentam transmissão zoonótica e causam infecções respiratórias e gastrointestinais em aves e mamíferos. Três espécies dessa família conseguiram infectar várias populações humanas: SARS-CoV-1, MERS-CoV e SARS-CoV-2. Este último vírus é o agente causador da doença chamada covid-19, declarada pela Organização Mundial da Saúde como uma pandemia devido ao seu modo de transmissão, período de latência e relatos em todo o mundo. No Equador, o primeiro caso de covid-19 foi diagnosticado em 28 de fevereiro de 2020 e as medidas sanitárias concentraram-se na suspensão de eventos massivos localmente. Vários dias depois, o isolamento começou com o decreto de Estado de Emergência Sanitária no qual o governo central e o Município de Quito inovaram em medidas de contingência e prevenção. Imediatamente depois, começou a imposição da quarentena e do toque de recolher nacional com a declaração do Estado de Exceção, mas o município de Guayaquil não foi capaz de enfrentar a contumácia do cidadão. Como resultado disso, Guayaquil registrou um crescimento exorbitante de mortes em hospitais, residências e ruas da cidade. Por outro lado, o modelo de gestão estabelecido em Quito minimizou o impacto da nova doença.

Microscopic and molecular evaluation of Strongyloides venezuelensis in an experimental life cycle using Wistar rats. / Evaluación microscópica y molecular de Strongyloides venezuelensis en un ciclo de vida experimental utilizando ratas Wistar

INTRODUCTION: Strongyloides venezuelensis is a nematode whose natural host is rats. It is used as a model for the investigation of human strongyloidiasis caused by S. stercoralis. The latter is a neglected tropical disease in Ecuador where there are no specific plans to mitigate this parasitic illness. OBJECTIVE: To evaluate the stages of S. venezuelensis in an experimental life cycle using Wistar rats. MATERIALS AND METHODS: Male Wistar rats were used to replicate the natural biological cycle of S. venezuelensis and describe its morphometric characteristics, as well as its parasitic development. Furthermore, the production of eggs per gram of feces was quantified using two diagnostic techniques and assessment of parasite load: Kato-Katz and qPCR. RESULTS: Viable larval stages (L1, L2, L3) could be obtained up to 96 hours through fecal culture. Parthenogenetic females were established in the duodenum on the fifth day postinfection. Fertile eggs were observed in the intestinal tissue and fresh feces where the production peak occurred on the 8th. day post-infection. Unlike Kato-Katz, qPCR detected parasitic DNA on days not typically reported. CONCLUSIONS: The larval migration of S. venezuelensis within the murine host in an experimental environment was equivalent to that described in its natural biological cycle. The Kato-Katz quantitative technique showed to be quick and low-cost, but the qPCR had greater diagnostic precision. This experimental life cycle can be used as a tool for the study of strongyloidiasis or other similar nematodiasis.

Introducción. Strongyloides venezuelensis es un nematodo cuyo huésped natural son las ratas. Se utiliza como modelo para la investigación de la estrongiloidiasis humana producida por S. stercoralis. Esta última es una enfermedad tropical desatendida que afecta al Ecuador, donde no existen planes específicos para mitigar esta parasitosis. Objetivo. Evaluar experimentalmente los estadios del ciclo de vida de S. venezuelensis utilizando ratas Wistar. Materiales y métodos. Se emplearon ratas Wistar macho para replicar el ciclo biológico natural de S. venezuelensis y describir sus características morfométricas y su desarrollo parasitario. Además, se cuantificó la producción de huevos por gramo de heces mediante dos técnicas de diagnóstico y valoración de carga parasitaria: Kato-Katz y qPCR. Resultados. Se obtuvieron estadios larvarios viables (L1, L2, L3) hasta las 96 horas del cultivo fecal. En el duodeno se establecieron hembras partenogenéticas a partir del quinto día de la infección. Se observaron huevos fértiles en el tejido intestinal inspeccionado y en las heces frescas, en las que el pico de producción ocurrió al octavo día de la infección. A diferencia del método Kato-Katz, la qPCR detectó ADN parasitario en días que usualmente no se reportan. Conclusiones. La migración larvaria de S. venezuelensis dentro del ratón en un ambiente experimental fue equivalente al descrito en un ciclo biológico natural. El método cuantitativo de Kato-Katz dio resultados inmediatos a más bajo costo, pero la qPCR tuvo mayor precisión diagnóstica. Este ciclo de vida experimental puede usarse como una herramienta para el estudio de la estrongiloidiasis u otras nematodiasis similares.

Microscopic and molecular evaluation of Strongyloides venezuelensis in an experimental life cycle using Wistar rats / Evaluación microscópica y molecular de Strongyloides venezuelensis en un ciclo de vida experimental utilizando ratas Wistar

Abstract | Introduction: Strongyloides venezuelensis is a nematode whose natural host is rats. It is used as a model for the investigation of human strongyloidiasis caused by S. stercoralis. The latter is a neglected tropical disease in Ecuador where there are no specific plans to mitigate this parasitic illness. Objective: To evaluate the stages of S. venezuelensis in an experimental life cycle using Wistar rats. Materials and methods: Male Wistar rats were used to replicate the natural biological cycle of S. venezuelensis and describe its morphometric characteristics, as well as its parasitic development. Furthermore, the production of eggs per gram of feces was quantified using two diagnostic techniques and assessment of parasite load: Kato-Katz and qPCR. Results: Viable larval stages (Lr L2, L3) could be obtained up to 96 hours through fecal culture. Parthenogenetic females were established in the duodenum on the fifth day postinfection. Fertile eggs were observed in the intestinal tissue and fresh feces where the production peak occurred on the 8th. day post-infection. Unlike Kato-Katz, qPCR detected parasitic DNA on days not typically reported. Conclusions: The larval migration of S. venezuelensis within the murine host in an experimental environment was equivalent to that described in its natural biological cycle. The Kato-Katz quantitative technique showed to be quick and low-cost, but the qPCR had greater diagnostic precision. This experimental life cycle can be used as a tool for the study of strongyloidiasis or other similar nematodiasis.

Resumen | Introducción. Strongyloides venezuelensis es un nematodo cuyo huésped natural son las ratas. Se utiliza como modelo para la investigación de la estrongiloidiasis humana producida por S. stercoralis. Esta última es una enfermedad tropical desatendida que afecta al Ecuador, donde no existen planes específicos para mitigar esta parasitosis. Objetivo. Evaluar experimentalmente los estadios del ciclo de vida de S. venezuelensis utilizando ratas Wistar. Materiales y métodos. Se emplearon ratas Wistar macho para replicar el ciclo biológico natural de S. venezuelensis y describir sus características morfométricas y su desarrollo parasitario. Además, se cuantificó la producción de huevos por gramo de heces mediante dos técnicas de diagnóstico y valoración de carga parasitaria: Kato-Katz y qPCR. Resultados. Se obtuvieron estadios larvarios viables (L1, L2, L3) hasta las 96 horas del cultivo fecal. En el duodeno se establecieron hembras partenogenéticas a partir del quinto día de la infección. Se observaron huevos fértiles en el tejido intestinal inspeccionado y en las heces frescas, en las que el pico de producción ocurrió al octavo día de la infección. A diferencia del método Kato-Katz, la qPCR detectó ADN parasitario en días que usualmente no se reportan. Conclusiones. La migración larvaria de S. venezuelensis dentro del ratón en un ambiente experimental fue equivalente al descrito en un ciclo biológico natural. El método cuantitativo de Kato-Katz dio resultados inmediatos a más bajo costo, pero la qPCR tuvo mayor precisión diagnóstica. Este ciclo de vida experimental puede usarse como una herramienta para el estudio de la estrongiloidiasis u otras nematodiasis similares.

Caregiver burden in caregivers of hospitalized older adults and its associated factors / Sobrecarga do cuidador em cuidadores de idosos hospitalizados e seus fatores associados

AIM: Acute care has some complications in the older adult, a frequently overlooked complication is caregiver burden. Scarce information is available on this matter. Therefore, the objective is to describe the factors associated with caregiver burden at the moment of discharge of a hospitalized older adult, in the Mexican healthcare context. METHOD: This is a secondary analysis of a hospital. Bivariate and multivariate analyses were performed with caregiving burden (measured with the Zarit scale) as the dependent variable. Other variables were tested in order to assess their association with caregiver burden: sociodemographic, health-related, depression, functionality, social support and hospital length of stay, caregiver expenses, quality of life and satisfaction with received care. RESULTS: A total of 111 older adults with their respective caregivers were assessed. From this sample, the mean age for older adults was 73 years (± standard deviation 7.9 years) and 65.7% (n = 73) were women. Caregiver burden was present in 39.6% (n = 44) of the individuals. Regarding the multivariate analyses, the only variable independently associated with caregiver burden was depression in the older adult, odds ratio 1.12 (95% confidence interval 1­1.25, p = 0.045). CONCLUSIONS: In concordance with previous work on this matter, according to our results depression in the older adult was a trigger of caregiver burden at discharge of acute care.

OBJETIVO: Os cuidados intensivos têm algumas complicações em idosos, e uma frequentemente negligenciada é a sobrecarga do cuidador, sobre a qual pouca informação está disponível. Desse modo, o objetivo deste trabalho é descrever os fatores associados com a sobrecarga do cuidador na alta hospitalar de um paciente idoso no contexto médico mexicano. METODOLOGIA: Esta é uma análise secundária de um hospital. Foram realizadas análises bivariadas e multivariadas tendo a sobrecarga do cuidador (medida com a escala de Zarit) como variável dependente. Outras variáveis foram testadas com o propósito de avaliar a sua associação com a sobrecarga do cuidador: sociodemográficas, de saúde, depressão, funcionalidade, apoio social e duração da estadia hospitalar, despesas do cuidador, qualidade de vida e satisfação com o cuidado recebido. RESULTADOS: Ao todo, 111 idosos com seus cuidadores foram avaliados. Dessa amostra, a idade média dos idosos foi de 73 anos (± desvio-padrão de 7,9 anos) e 65,7% (n=73) eram mulheres. A sobrecarga do cuidador estava presente em 39,6% (n=44) dos indivíduos. Com relação às análises multivariadas, a única variável independentemente associada com a sobrecarga do cuidador foi a depressão nos idosos, com razão de probabilidade de 1,12 (95% intervalo de confiança 1­1.25, p = 0.045). CONCLUSÕES: Em conformidade com trabalhos anteriores realizados sobre este assunto, de acordo com os nossos resultados a depressão nos idosos foi um gatilho para a sobrecarga do cuidador na alta dos cuidados intensivos.

Factores asociados al estado nutricional en pacientes adultos mayores hospitalizados / Factors associated with nutritional status in hospitalized elderly patients

Resumen Introducción: la desnutrición es una condición frecuente en las personas mayores de 65 años. El mal estado nutricional se ha relacionado con mayores estancias hospitalarias, complicaciones, aumento en comorbilidades y mortalidad. Este estudio busca describir la relación entre el estado nutricional de adultos mayores hospitalizados y factores como red de apoyo, funcionalidad y presencia de demencia. Material y métodos: se llevó a cabo un estudio descriptivo de corte transversal analítico basado en la revisión de historias de los pacientes hospitalizados por el Servicio de Geriatría del Hospital Universitario San Ignacio de Bogotá D.C. La variable dependiente fue el estado nutricional medido con el instrumento Mini-Nutritional Assessment y se usaron como variables independientes factores sociodemográficos, el estado funcional, el diagnóstico previo de demencia, la red de apoyo, delirium, tiempo de estancia hospitalaria, comorbilidades. Resultados: se incluyeron 887 pacientes con edad promedio de 85.43 años, de los cuales 43.07% eran hombres. En el modelo de regresión logística la presencia de delirium OR 2.27 (IC 1.48-3.48), el diagnóstico previo de demencia OR 2.48 (IC 1.63-3.77) y el mayor tiempo de estancia hospitalaria OR 1.05 (IC 1.0-1.10) tuvieron una asociación de aumento de riesgo con desnutrición. Conclusión: se encontró una asociación significativa entre mal estado nutricional con menor funcionalidad, mayor estancia hospitalaria, tener diagnóstico de demencia, presentar delirium, tener un mayor número de comorbilidad y mayor mortalidad. Se requieren más estudios que aborden este tema. (Acta Med Colomb 2018; 43: 69-73).

Abstract Introduction: malnutrition is a prevalent condition in people older than 65 years. Poor nutritional status has been associated to longer hospital stays, complications, increased comorbidities and mortality. This study aims to describe the relationship between the nutritional status of hospitalized older adults and factors such as support network, functionality and the presence of dementia. Materials and methods: a descriptive cross-sectional analytical study was carried out based on the revision of medical records of patients hospitalized by the Geriatrics Unit at San Ignacio University Hospital in Bogota, Colombia. Nutritional status measured through theMini-Nutritional Assessment was considered to be the dependent variable. Sociodemographic factors, functional status, previous diagnosis of dementia, support network, delirium, length of hospital stay and presence of comorbidities were used as independent variables. Results: 887 patients with an average age of 85.43 were included. 43.07% were men. The logistic regression model revealed that the presence of delirium OR 2.27 (CI 1.48-3.48), the diagnosis of dementia OR 2.48 (CI 1.63-3.77) and the longer hospital stay OR 1.05 (CI 1.0-1.10) had an association of increased risk with malnutrition. Conclusion: a significant association was found between poor nutritional status with decreased functionality, longer hospital stays, having a diagnosis of dementia, presenting delirium, having a greater number of comorbidity and higher mortality. Future studies addressing this issue are required. (Acta Med Colomb 2018; 43: 69-73).

The Indianapolis Flux Experiment (INFLUX): A test-bed for developing urban greenhouse gas emission measurements.

The objective of the Indianapolis Flux Experiment (INFLUX) is to develop, evaluate and improve methods for measuring greenhouse gas (GHG) emissions from cities. INFLUX's scientific objectives are to quantify CO2 and CH4 emission rates at 1 km resolution with a 10% or better accuracy and precision, to determine whole-city emissions with similar skill, and to achieve high (weekly or finer) temporal resolution at both spatial resolutions. The experiment employs atmospheric GHG measurements from both towers and aircraft, atmospheric transport observations and models, and activity-based inventory products to quantify urban GHG emissions. Multiple, independent methods for estimating urban emissions are a central facet of our experimental design. INFLUX was initiated in 2010 and measurements and analyses are ongoing. To date we have quantified urban atmospheric GHG enhancements using aircraft and towers with measurements collected over multiple years, and have estimated whole-city CO2 and CH4 emissions using aircraft and tower GHG measurements, and inventory methods. Significant differences exist across methods; these differences have not yet been resolved; research to reduce uncertainties and reconcile these differences is underway. Sectorally- and spatially-resolved flux estimates, and detection of changes of fluxes over time, are also active research topics. Major challenges include developing methods for distinguishing anthropogenic from biogenic CO2 fluxes, improving our ability to interpret atmospheric GHG measurements close to urban GHG sources and across a broader range of atmospheric stability conditions, and quantifying uncertainties in inventory data products. INFLUX data and tools are intended to serve as an open resource and test bed for future investigations. Well-documented, public archival of data and methods is under development in support of this objective.

High-resolution atmospheric inversion of urban CO2 emissions during the dormant season of the Indianapolis Flux Experiment (INFLUX).

Based on a uniquely dense network of surface towers measuring continuously the atmospheric concentrations of greenhouse gases (GHGs), we developed the first comprehensive monitoring systems of CO2 emissions at high resolution over the city of Indianapolis. The urban inversion evaluated over the 2012-2013 dormant season showed a statistically significant increase of about 20% (from 4.5 to 5.7 MtC ± 0.23 MtC) compared to the Hestia CO2 emission estimate, a state-of-the-art building-level emission product. Spatial structures in prior emission errors, mostly undetermined, appeared to affect the spatial pattern in the inverse solution and the total carbon budget over the entire area by up to 15%, while the inverse solution remains fairly insensitive to the CO2 boundary inflow and to the different prior emissions (i.e., ODIAC). Preceding the surface emission optimization, we improved the atmospheric simulations using a meteorological data assimilation system also informing our Bayesian inversion system through updated observations error variances. Finally, we estimated the uncertainties associated with undetermined parameters using an ensemble of inversions. The total CO2 emissions based on the ensemble mean and quartiles (5.26-5.91 MtC) were statistically different compared to the prior total emissions (4.1 to 4.5 MtC). Considering the relatively small sensitivity to the different parameters, we conclude that atmospheric inversions are potentially able to constrain the carbon budget of the city, assuming sufficient data to measure the inflow of GHG over the city, but additional information on prior emission error structures are required to determine the spatial structures of urban emissions at high resolution.

Epithelioid inflammatory myofibroblastic sarcoma: a case report.

Inflammatory myofibroblastic tumor (IMT) of the lung is a rare malignancy with few cases reported in the literature. Histologically, it is composed by spindle cells and an infiltrate of inflammatory cells. Children and young, non-smoking adults constitute the majority of cases, the clinical behavior ranges from a benign entity to a malignant process with rapid recurrence and metastatic progression. We present a case of epithelioid inflammatory myofibroblastic sarcoma (EIMS) of the pleura, a malignant variant of IMT, which was initially treated with debulking surgical resection followed by systemic chemotherapy. The tumor was found to have an anaplastic lymphoma kinase (ALK) gene rearrangement. An ALK directed tyrosine kinase inhibitor was used with an impressive response, the patient remains in remission nearly 1 year after presentation. The pathogenesis, pathologic findings, clinical behavior and imaging of pulmonary EIMS are discussed.

Incidencia de trombosis de stents coronarios en el ®mundo real¼ / Incidence of coronary stent thrombosis in the ®real world¼

ANTECEDENTES: la evidencia disponible de stents liberadores de medicamento proviene de estudios controlados con estrictos criterios de inclusión, limitando sus conclusiones y haciendo difícil la aplicación de sus resultados en el mundo real. OBJETIVO: determinar la incidencia de trombosis de stents liberadores y no liberadores de medicamento en pacientes del ®mundo real¼. METODOLOGÍA: estudio de incidencia para determinar el número de casos de trombosis de stents implantados, mediante información obtenida a partir de historias clínicas, bases de datos y seguimiento clínico, y con base en características demográficas, factores de riesgo, consumo de clopidogrel y casos de trombosis del stent con un seguimiento de cero días a un año. RESULTADOS: 640 stents implantados (69,2% no medicados, 30,8% medicados de los cuales 18,9% eran medicados con placlitaxel y 11,9% medicados con sirolimus). Se identificaron doce eventos de trombosis (siete stents medicados y cinco no medicados). La incidencia de trombosis con cualquier tipo de stent fue de 1,88% (IC 95% 0,97-3,28). La incidencia de trombosis con stent medicado fue 3,55% (IC 95% 1,43-7,32), y con stent no medicado 1,13% (IC 95% 0,37-2,64) p=0,000. El riesgo relativo de trombosis con stent medicado es de 3,14 (IC 95% 1,01-9,78) p=0,037. El riesgo relativo de presentar trombosis con stent medicado en infarto agudo del miocardio es 8,11 (IC 95% 2,32-28,31) p=0,001. CONCLUSIONES: la incidencia de trombosis del stent aumenta en el mundo real, y existe mayor riesgo de trombosis de stents medicados especialmente cuando son implantados en el contexto de un infarto agudo del miocardio. Es necesario realizar estudios futuros que involucren una población de pacientes más amplia y con seguimiento a largo plazo.

BACKGROUND: The existing evidence of drug-eluting stents comes from controlled studies done with strict inclusion criteria, limiting their conclusions and making difficult to apply their findings in the real world.Objectives: determine the incidence of thrombosis between bare metal stents versus drug-eluting stents in patients in the ®real world¼. METHODS: incidence study to determine the number of cases of thrombosis in implanted stents through information gathered from clinical records, data bases and clinical follow-up, based on demographic characteristics, risk factors, clopidogrel treatment and events of stent thrombosis with a 0 days to 1 year follow-up. RESULTS: 640 stents were implanted. 69.2% were bare metal stents and 30.8% drug-eluting stents, from which 18.9% were with placlitaxel and 11.9% with sirolimus. 12 thrombosis events were identified (7 with drug-eluting stents and 5 with bare metal stents). The incidence of thrombosis with any kind of stent was 1.88 %( CI 95% 0.97-3.28). The incidence of thrombosis with drug-eluting stents was 3.55% (CI 95%1.43-7.32), and with bare metal stents 1.13% (CI 95% 0.37-2.64) p=0.000. The relative risk of thrombosis with drug eluting stents is 3.14 (CI 95%1.01-9.78) p=0.037. The relative risk of thrombosis with drug eluting stents and acute myocardial infarction is 8.11 (CI 95%2.32-28.31) p=0,001. CONCLUSIONS: there is an increased incidence of thrombosis of coronary stents in the real world and a greater risk of thrombosis with drug eluting stents, especially when implanted in the context of an acute myocardial infarction. It is necessary to conduct further studies that may involve a higher sample of patients population and long-term follow-up.