Association between chronic lymphocytic thyroiditis and papillary thyroid carcinoma: a retrospective study in surgical specimens / Asociación entre tiroiditis linfocítica crónica y cáncer papilar de tiroides: estudio retrospectivo de especímenes quirúrgicos

INTRODUCTION: The hypothesis of an association between papillary thyroid carcinoma (PTC) and chronic lymphocytic thyroiditis (CLT) continues to generate debate. Retrospective studies suggest that there is a greater probability of diagnosing a PTC in surgical specimens with CLT; however, prospective studies suggest that there is no true increase in risk. METHODS: An analytical, cross-section measurement and retrospective study was carried out considering gender, age and diagnosis of CLT and PTC in surgical specimens. A binary logistic regression model was proposed to predict the probability of carrying out the diagnosis of PTC based on the diagnosis of CLT, gender and age. RESULTS: The study population consisted of 1136 patients, 1047 (92.2%) women and 89 (7.8%) men, with an average age of 47.5±14.3 years. The prevalence of CLT and PTC was 14.9% and 16.1% respectively. Coexistence between PTC and CLT was found in 44 patients, corresponding to 3.9% of the population. Our logistic regression model suggests that the probability of diagnosing PTC in surgical specimens of male patients under 40 years old and with CLT is 53.8%. CONCLUSIONS: We suggest that there is a greater probability of diagnosing PTC in surgical specimens with confirmatory histological data for CLT; in addition, in males under 40 years old this probability increases

INTRODUCCIÓN: La hipótesis que sugiere una asociación entre el cáncer papilar de tiroides (PTC, por sus siglas en inglés) y la tiroiditis linfocítica crónica (CLT, por sus siglas en inglés) sigue generando debate. Los estudios retrospectivos sugieren que existe una mayor probabilidad de realizar un diagnóstico de PTC en las muestras quirúrgicas de CLT. Los estudios prospectivos sugieren que no existe un incremento real del riesgo. MÉTODOS: Se realizó un estudio analítico de medición transversal y temporalidad retrospectiva en cuanto a sexo, edad, diagnóstico de CLT y espécimen quirúrgico de PTC. Se propuso un modelo de regresión logística binaria para predecir la probabilidad de realizarse un diagnóstico de PTC basado en el diagnóstico de CLT, sexo y edad. RESULTADOS: La población de estudio consistió en 1.136 pacientes, 1.047 mujeres (92,2%) y 89 varones (7,8%), con una edad media de 47,5 ± 14,3 años. La prevalencia de CLT y PTC fue del 14,9% y 16,1%, respectivamente. La coexistencia de PTC y CLT fue encontrada en 44 pacientes, correspondiente al 3,9% de la población. Nuestro modelo de regresión logística sugiere que la probabilidad de realizar el diagnóstico de PTC en muestras quirúrgicas de pacientes varones con edades inferiores a 40 años y con CLT es del 53,8%. CONCLUSIONES: Sugerimos que existe una mayor probabilidad de diagnosticar PTC en muestras quirúrgicas con datos histológicos confirmatorios de CLT; además, esta probabilidad puede modificarse sobre la base de sexo masculino y edad superior a 40 años

Association between chronic lymphocytic thyroiditis and papillary thyroid carcinoma: A retrospective study in surgical specimens.

INTRODUCTION: The hypothesis of an association between papillary thyroid carcinoma (PTC) and chronic lymphocytic thyroiditis (CLT) continues to generate debate. Retrospective studies suggest that there is a greater probability of diagnosing a PTC in surgical specimens with CLT; however, prospective studies suggest that there is no true increase in risk. METHODS: An analytical, cross-section measurement and retrospective study was carried out considering gender, age and diagnosis of CLT and PTC in surgical specimens. A binary logistic regression model was proposed to predict the probability of carrying out the diagnosis of PTC based on the diagnosis of CLT, gender and age. RESULTS: The study population consisted of 1136 patients, 1047 (92.2%) women and 89 (7.8%) men, with an average age of 47.5±14.3 years. The prevalence of CLT and PTC was 14.9% and 16.1% respectively. Coexistence between PTC and CLT was found in 44 patients, corresponding to 3.9% of the population. Our logistic regression model suggests that the probability of diagnosing PTC in surgical specimens of male patients under 40 years old and with CLT is 53.8%. CONCLUSIONS: We suggest that there is a greater probability of diagnosing PTC in surgical specimens with confirmatory histological data for CLT; in addition, in males under 40 years old this probability increases.