ABSTRACT
BACKGROUND: Patients with duodenal ulcer are not at high risk although Helicobacter pylori infection is no doubt associated with gastric cancer development. However, little is known about the risk after long-term follow-up. AIMS: We investigated the incidence for gastric cancer development in peptic ulcer patients in a long term. PATIENTS AND METHODS: Between 1965 and 2004, endoscopic follow-up of more than 1 year was conducted on 1504 peptic ulcer patients in our hospital. They consisted of 978 gastric ulcer patients, 444 duodenal ulcer patients and 82 gastric and duodenal ulcer patients. Gastric and duodenal ulcer patients were excluded from the analysis because of their limited number. RESULTS: Gastric cancers developed in 32 (3.3%) of gastric ulcer patients and 3 (0.68%) of duodenal ulcer patients. Kaplan-Meier analysis showed that the incidence of gastric cancer in duodenal ulcer patients was significantly lower than that in gastric ulcer patients (log-rank test, p=0.0059). Cox's proportional hazard model denoted the relative risk for duodenal ulcer against gastric ulcer adjusted by sex and age as 0.23 (95% CI: 0.072-0.77, p=0.016). CONCLUSION: The risk for patients with duodenal ulcer to develop gastric cancer over the long term is significantly less than in those with gastric ulcer.
Subject(s)
Duodenal Ulcer/epidemiology , Stomach Neoplasms/epidemiology , Stomach Ulcer/epidemiology , Female , Follow-Up Studies , Humans , Incidence , Japan/epidemiology , Kaplan-Meier Estimate , Male , Middle Aged , Proportional Hazards Models , Retrospective Studies , Risk AssessmentSubject(s)
Albumins/metabolism , Bilirubin/metabolism , Animals , Bilirubin/blood , Cholestasis/blood , Chromatography, Gel , Male , Protein Binding , RatsSubject(s)
Alanine Transaminase/blood , Diet, Reducing , Obesity/enzymology , Energy Intake , Humans , Male , Time FactorsSubject(s)
Body Weight , Glucose Tolerance Test , Lipids/blood , Obesity/blood , Transaminases/blood , Adult , Aged , Diet, Reducing , Humans , Hyperlipidemias/etiology , Male , Middle Aged , Obesity/enzymologyABSTRACT
New method of differential diagnosis of gastric cancer was reported. After intravenous 32P administration, lesion was counted by small catheter-type readiation detector system under gastrofiberscopic direct vision control. Optimum counting time was examined in man and it was found to be between 20 to 50 hours after intravenous administration of 32P. Under the currently available technology of miniature detector, still beta-emitting carcinopohilic agent was found to be the agent of choice to this end, since gamma-emitting carcinophilic agents can not provide data originated only from the gastric mucosa in question.
Subject(s)
Scintillation Counting/instrumentation , Stomach Neoplasms/diagnostic imaging , Catheterization , Fiber Optic Technology/instrumentation , Gallium Radioisotopes , Humans , Phosphorus Radioisotopes , Radionuclide Imaging , Scintillation Counting/methods , Semiconductors , Technetium , Time FactorsSubject(s)
Alanine Transaminase/blood , Liver Function Tests , Obesity/physiopathology , Adult , Aged , Blood Glucose/analysis , Female , Glucose Tolerance Test , Humans , Insulin/blood , Male , Middle Aged , Obesity/bloodABSTRACT
In order to find a relationship between ductal hyperplasia and carcinoma of the pancreas, histological and histochemical examinations were made on pancreatic specimens of 1,174 autopsy patients with special attention to the age incidence of the former. Ductal hyperplasia was divided into 3 types; nonpapillary, papillary, and atypical hyperplasia. All three types of hyperplasia and ductal carcinoma showed a similar tinctorial property in mucous histochemistry. In general, atypical hyperplasia was seen in the pancreas having papillary hyperplasia which was found in the pancreas associated with nonpapillary hyperplasia. All three types of hyperplasia were apparently more frequent in cancerous pancreases than in non-cancerous ones. They were also more common in the head of the pancreas than in the body and tail. Age incidence also suggests a sequential change from nonpapillary hyperplasia through papillary and atypical ones to carcinoma.
Subject(s)
Pancreatic Ducts/pathology , Pancreatic Neoplasms/pathology , Adolescent , Adult , Age Factors , Aged , Cell Transformation, Neoplastic , Child , Child, Preschool , Epithelium/pathology , Female , Humans , Hyperplasia/classification , Hyperplasia/metabolism , Hyperplasia/pathology , Infant , Infant, Newborn , Male , Middle Aged , Mucus/analysis , Pancreatic Ducts/metabolism , Pancreatic Neoplasms/analysis , Precancerous Conditions , Sex FactorsSubject(s)
Glucose Tolerance Test , Hyperlipidemias/physiopathology , Liver/metabolism , Obesity/physiopathology , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Aging , Kidney/pathology , Adult , Aged , Hawaii , Humans , Japan/ethnology , Kidney/anatomy & histology , Male , Middle Aged , Organ SizeABSTRACT
The role of period between administration of CCl4 and feeding of 2,7-bis-(acetamido)fluorene in the hepatocarcinogenesis of mice was analyzed by using 14 groups of different feeding schedules. Simultaneous treatment with CCl4 and either continuous or intermittent feeding of 2,7-bis(acetamido)fluorene increased the average number of hepatic nodules and the incidence of hepatomas, while separation of 8-week feeding of 2,7-bis(acetamido)fluorene from 8 week treatment with CCl4 did not accelerate the hepatocarcinogenesis. Alternate treatment with CCl4 and 2,7-bis(acetamido)fluorene increased the average number of hepatic nodules but failed to induce hepatomas. Allyl alcohol, which is a hepatotoxic substance as is CCl4, also failed to accelerate hepatocarcinogenesis of 2,7-bis(acetamido)fluorene. Concerning the feeding schedule of 2,7-bis(acetamido)fluorene alone, the intermittent one-week feeding of the carcinogen with 3-week intervals decreased the average number of hepatic nodules as compared with the continuous feeding of the carcinogen.
Subject(s)
2-Acetylaminofluorene/analogs & derivatives , 2-Acetylaminofluorene/toxicity , Carbon Tetrachloride/pharmacology , Carcinoma, Hepatocellular/chemically induced , Fluorenes/toxicity , Liver Neoplasms/chemically induced , 2-Acetylaminofluorene/administration & dosage , Animals , Carbon Tetrachloride/administration & dosage , Female , Hyperplasia/chemically induced , Male , Mice , Neoplasms, Experimental/chemically induced , Sex Factors , Time FactorsABSTRACT
An autopsy case of an enormous shunt between intrahepatic portal vein and hepatic vein in a 57-year-old man who showed an Inose's type of hepatocerebral disorder for 6 years is described. The shunt measuring up to more than 1 cm in diameter was located in the right-upper angle of the right liver lobe. The wall of the shunt lacked both the muscular layer and the elastic lamellae. Based upon the histopathology and the clinical history, this shunt was considered not to be a congenital malformation but a vascular disorder resulted from the parenchymal collapse of the liver.
