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1.
Int J Surg Case Rep ; 122: 110103, 2024 Sep.
Article in English | MEDLINE | ID: mdl-39094321

ABSTRACT

INTRODUCTION: Spinal cord schistosomiasis is an extremely rare entity presenting with a wide range of neurological symptoms. The early diagnosis and treatment can improve neurological outcome. Histopathological examination is the gold standard for establishing the diagnosis of spinal schistosomiasis, revealing schistosoma eggs. CASE REPORT: We report a case of a 13-year-old male, from Mauritania, with a history of drinking unsafe water, presenting with an acute urinary retention and gait disturbances evolving for 1 month. His clinical examination found an incomplete conus medullary syndrome made up of urinary retention, lively patellar reflexes on the right, ataxia when walking on the same side and indifferent cutaneous planter reflex. The magnetic resonance imaging (MRI) on dorsal spine revealed an enhancing mass involving the conus medullaris in the L1-L2 region suggestive of an arteriovenous malformation or a cavernoma. The resection tissue specimens for diagnosis were fixed with 10 % buffered formalin. The slides were stained with haematoxylin-eosin staining for light microscopy. The diagnosis of schistosomiasis spinal cord was retained. The child has been treated with oral praziquantel 25 mg/kg. DISCUSSION: Diagnosis of schistosomiasis is based on a combination of clinical evaluation, imaging studies, and laboratory tests. However, definitive diagnosis typically requires histopathological examination of spinal cord lesions obtained through biopsy. Differential diagnosis is broad, including an acute vascular event and/or tumor, especially in children from endemic areas for schistosomiasis. CONCLUSION: Schistosomiasis infection should be suspected when encountering medullary lesion associated to peripheral hypereosinophilia. Surgical excision combined with praziquantel may help improve neurological deficits.

2.
Clin Biomech (Bristol, Avon) ; 115: 106260, 2024 May.
Article in English | MEDLINE | ID: mdl-38714109

ABSTRACT

BACKGROUND: The aim was to assess the direction of distal radius fractures and their relationship to the ulnar head. METHODS: We reviewed the 160 wrist radiographs. The fracture line was measured on the postero-anterior and lateral radiographs relative to the long axis of the forearm and the relationship to the ulnar head. FINDINGS: PA radiographs: the fracture line ran distal ulnar to proximal radial (ulnar to radial) in 11%, transverse in 74% and distal radial to proximal ulnar (radial to ulnar) in 16%. Lateral radiographs: the fracture line ran distal volar to proximal dorsal in 88%, transverse in two 1% and dorsal to volar in 11%. Radial shift (7.5%) only occurred with ulnar to radial or transverse fractures. The ulnar to radial fracture line started at the proximal end of the ulnar head/distal radio-ulnar joint in 88%. The radial to ulnar fracture line started ended a mean of 2.5 mm proximal to the distal radio-ulnar joint (p < 0.01). The transverse fracture line started at the base of the distal radio-ulnar joint in 53% and proximally in 47%. INTERPRETATION: There are two distinct coronal patterns: radial to ulnar ending c. 2 mm proximal to the distal radio-ulnar joint; ulnar to radial starting at the proximal distal radio-ulnar joint. There may be third pattern - transverse fractures; these may be variants of the above. Sagittally the main direction is volar to dorsal but 11% are obverse. This is the first description of distinct fracture patterns in extra-articular distal radius fractures. In addition the fracture patterns appear to correlate with different directions of force transmission which fit with our understanding of falling and the relatively uncontrolled impact of the wrist/hand with the ground. These patterns of fracture propagation help understand how the biomechanics of wrist fractures and may enable prediction of collapse.


Subject(s)
Radiography , Radius Fractures , Ulna , Humans , Radius Fractures/diagnostic imaging , Radius Fractures/physiopathology , Ulna/diagnostic imaging , Ulna/physiopathology , Male , Female , Middle Aged , Adult , Aged , Aged, 80 and over , Wrist Joint/diagnostic imaging , Wrist Joint/physiopathology , Wrist Injuries/diagnostic imaging , Wrist Injuries/physiopathology , Adolescent , Young Adult
6.
Dalton Trans ; 45(17): 7294-302, 2016 04 25.
Article in English | MEDLINE | ID: mdl-27010224

ABSTRACT

Tetrahedrites, a class of earth-abundant minerals, exhibit extremely low thermal conductivity values making them promising candidates for thermoelectric applications at high temperatures. Herein, we extend investigations on these materials to specimens substituted on both the Cu and Sb sites by reporting on the thermoelectric properties of polycrystalline Cu12-xCoxSb4-yTeyS13 in a wide range of temperatures (2-700 K). All prepared samples exhibit p-type heavily-doped semiconducting behavior with relatively low electrical resistivity values. These substitutions have little influence on the thermal conductivity, which remains very low in the whole temperature range (∼0.7 W m(-1) K(-1)). Although the double-substituted samples exhibit higher ZT values with respect to the parent tetrahedrite Cu12Sb4S13, the maximum ZT of 0.80 reached at 700 K for (x,y) = (0.82, 0.41) remains comparable to the values obtained in compounds solely substituted with Co or Te.

7.
J Hand Surg Eur Vol ; 41(6): 638-42, 2016 Jul.
Article in English | MEDLINE | ID: mdl-26802792

ABSTRACT

UNLABELLED: Previous research has not established a consistent difference in hand size or carpal tunnel cross-sectional area between patients with and without carpal tunnel syndrome. We tested the hypothesis that there would be no difference in relative carpal tunnel sizes between men and women. We defined relative carpal tunnel size as the cross-sectional areas at the inlet (level of the pisiform) and outlet (level of the hook of the hamate) of the carpal tunnel divided by the length of the capitate (as a measure of hand size). We made the measurements on the magnetic resonance imaging scans of 50 men and 50 women taken for symptoms unrelated to carpal tunnel syndrome. The mean relative cross-sectional area was appreciably smaller in women than men (p < 0.05). This suggests that the carpal tunnel cross-sectional area relative to the size of the hand is constitutionally smaller in women than in men. This could in theory be a significant factor in patients developing carpal tunnel syndrome. LEVEL OF EVIDENCE: V.


Subject(s)
Carpal Tunnel Syndrome/diagnostic imaging , Carpal Tunnel Syndrome/etiology , Sex Factors , Adolescent , Adult , Aged , Carpal Bones/diagnostic imaging , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Retrospective Studies , Young Adult
8.
Appl Radiat Isot ; 100: 65-9, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25557979

ABSTRACT

This study intends to measure the radiation dose to patients and staff during (i) Dynamic Hip Screw (DHS) and (ii) Dynamic Cannula Screw (DCS) and to evaluate entrance surface Air kerma (ESAK) dose and organ doses and effective doses. Calibrated Thermoluminescence dosimeters (TLD-GR200A) were used. The mean patients' doses were 0.46mGy and 0.07mGy for DHS and DCS procedures, respectively. The mean staff doses at the thyroid and chest were 4.69mGy and 1.21mGy per procedure. The mean organ and effective dose for patients and staff were higher in DHS compared to DCS. Orthopedic surgeons were exposed to unnecessary radiation doses due to the lack of protection measures. The radiation dose per hip procedure is within the safety limit and less than the previous studies.

10.
Bull Soc Pathol Exot ; 105(4): 259-61, 2012 Oct.
Article in French | MEDLINE | ID: mdl-23086495

ABSTRACT

The aim of this study is to consider the parietal complications of the hydatid cyst of the liver: the subcutaneous rupture of the cyst and spontaneous cutaneous fistula of liver hydatid cyst. 1(st) case: A 24-year-old woman, who underwent surgery 10 years ago for hydatid cyst of the liver, was admitted for a right hypochondrium mass and a fistula draining clear liquid containing cystic elements. Computed tomography (CT) showed a large cystic lesion in the subcutaneous tissue communicating with another cystic mass in the liver. The diagnosis of a cyst-cutaneous fistula due to a peritoneal hydatid cyst was established. The patient underwent surgical treatment and recovered uneventfully. 2(nd) case: A 40-year-old woman presented with a mass in her right hypochondrium. The diagnosis of subcutaneous rupture of a hydatid cyst of liver was established by ultrasonography and CT-scan. The patient underwent surgical treatment and recovered uneventfully. Parietal complications of hydatid cyst of the liver are extremely rare, clinical presentation can be derailing. The diagnosis is usually established by ultrasonography and CT-scan.


Subject(s)
Cutaneous Fistula/etiology , Echinococcosis, Hepatic/complications , Fistula/etiology , Liver Diseases/etiology , Abdominal Wall/parasitology , Adult , Albendazole/therapeutic use , Animals , Anthelmintics/therapeutic use , Combined Modality Therapy , Cutaneous Fistula/diagnostic imaging , Echinococcosis, Hepatic/diagnostic imaging , Echinococcosis, Hepatic/drug therapy , Echinococcosis, Hepatic/surgery , Female , Fistula/diagnostic imaging , Fistula/surgery , Humans , Liver Diseases/diagnostic imaging , Liver Diseases/surgery , Radiography , Rupture, Spontaneous , Subcutaneous Tissue/parasitology , Tunisia , Ultrasonography , Young Adult
11.
Neurol Sci ; 32(4): 727-9, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21681367

ABSTRACT

Although peripheral neuropathy is a common complication of microscopic angiitis, manifestations involving the muscle and the central nervous system have been rarely reported. We describe a 48-year-old man who rapidly developed a clinical picture of mononeuritis multiplex. A month after the appearance of the primary symptoms, he became comatose and had left hemiplegia in relation with a massive cerebral haematoma. Laboratory data revealed signs of inflammation, glomerular dysfunction with microhaematuria, and positive myeloperoxidase-antineutrophil cytoplasmic antibodies. The neuromuscular biopsy disclosed a small-vessel vasculitis, consisting with microscopic angiitis, associated with myositis and extensive axonal loss. The patient had surgical evacuation of the haematoma and received immunosuppressive therapy with good outcome. Thus, microscopic angiitis should be considered as a differential diagnosis in cases of myositis and intracerebral haemorrhage.


Subject(s)
Central Nervous System/pathology , Microscopic Polyangiitis/pathology , Peripheral Nervous System/pathology , Action Potentials/physiology , Anti-Inflammatory Agents/therapeutic use , Biopsy , Cyclophosphamide/therapeutic use , Electromyography , Humans , Immunosuppressive Agents/therapeutic use , Intracranial Hemorrhages/complications , Intracranial Hemorrhages/pathology , Male , Microscopic Polyangiitis/complications , Middle Aged , Mononeuropathies/complications , Mononeuropathies/pathology , Muscle, Skeletal/innervation , Muscle, Skeletal/pathology , Myositis/complications , Myositis/pathology , Peroneal Nerve/pathology , Prednisone/therapeutic use , Recovery of Function , Tomography, X-Ray Computed , Vasculitis, Central Nervous System/complications , Vasculitis, Central Nervous System/pathology
12.
Eur J Phys Rehabil Med ; 46(4): 563-80, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21224789

ABSTRACT

Scoliosis is an important cause of disability in childhood, due to its incidence and limitation on ability. In neurodevelopmental disabilities, scoliosis worsens the already limited functional capacities of the child and can thwart abilities partially recovered through rehabilitation. In celebral palsied children (CP), scoliosis is considered a consequence of damage to the central nervous system or a complication of a peripheral impairment, in particular, through obliquity of pelvis, of the unilateral dislocation of hip. In order to explain the scoliosis of central origin, primitive and pathological reflexes, reactions or automatisms must be taken into account, especially the asymmetrical ones. This contradicts the absence of scoliosis in hemiplegia. On the contrary, symmetrical patterns should act as protective factors. However, the greater incidence of scoliosis in tetraplegia than in dipegia does not confirm this idea. Scoliosis is secondary when it is linked to an unilateral hip dislocation for side of convexity, proximity, measure and timing sequence. In childhood neuromuscular diseases (NMD), scoliosis is the unavoidable consequence of muscle weakness. The only protective factor may be muscle stiffness in case of fibrotic degeneration. The main curve is reducible for longer periods, while the less reducible secondary one at cervical level can limit the correction possibilities, due to the need to keep the head aliened. In spina bifida (SB) children, lesional and supralesional scoliosis can be present. In the former, the malformative ones directly derive from the vertebrae involved in the myelomeningocele and the secondary ones develop from the unilateral hip dislocation similar to CP, or from muscular imbalance (a typical feature of SB, especially for lower lumbar levels) or from primitive skeletal malformations of pelvic girdle or lower limbs. The acquired ones are caused by muscle weakness as in NMD. In the supralesional scoliosis, the curve is the consequence of an impairment in neurological structures especially of ponto-cerebellar carrefour or of an acquired tethered cord and may affect any segment of spinal column, also above the primitive lesion level. The scoliosis in neurodevelopmental disabilities can be treated conservatively with corsets and postural systems, with limited results. or through a surgical approach, often made difficult due to the multiple impairments present in the same patient.


Subject(s)
Developmental Disabilities/complications , Developmental Disabilities/rehabilitation , Neuromuscular Diseases/complications , Neuromuscular Diseases/rehabilitation , Scoliosis/complications , Scoliosis/rehabilitation , Cerebral Palsy/complications , Cerebral Palsy/rehabilitation , Child , Humans , Muscular Dystrophy, Duchenne/complications , Muscular Dystrophy, Duchenne/rehabilitation , Spinal Dysraphism/complications , Spinal Dysraphism/rehabilitation
13.
Pathologica ; 101(2): 93-6, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19886556

ABSTRACT

Endometrial stromal sarcoma (ESS) is rarely localized in extrauterine sites if metastasis or local extension of the primary uterine tumour are excluded, and diagnosis can be delayed because of the unusual site. We report a case of abdominal ESS in a 45-year-old woman who presented with an abdominal complaint. Ultrasound of the abdomen showed a large multiloculated cystic mass. The complete excision of the tumour revealed ESS arising in endometriosis. The tumour expressed hormonal receptors and the patient was administered hormonal therapy. ESS has a better prognosis than the sarcoma that is part of differential diagnosis, and is associated with endometriosis in about one-half of cases.


Subject(s)
Abdominal Neoplasms/pathology , Endometriosis/pathology , Sarcoma, Endometrial Stromal/pathology , Abdominal Neoplasms/metabolism , Abdominal Neoplasms/surgery , Cysts/pathology , Diagnosis, Differential , Female , Gastrointestinal Stromal Tumors/pathology , Humans , Immunohistochemistry , Middle Aged , Nerve Sheath Neoplasms/pathology , Sarcoma/pathology , Sarcoma, Endometrial Stromal/metabolism , Sarcoma, Endometrial Stromal/surgery , Sarcoma, Synovial/pathology
14.
Pathologica ; 101(2): 97-100, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19886557

ABSTRACT

Anaplastic large cell lymphoma (ALCL) represents approximately 10 to 30% of all childhood non-Hodgkin lymphomas. It frequently involves both lymph nodes and extranodal sites whereas primary or secondary muscular involvements are quite uncommon. We describe a case of an 8-year-old boy presented with one month progressively swelling right buttock mass without association of lymphadenopathy or skin extension. Biopsy of the lesion showed large anaplastic cells with voluminous and abundant cytoplasm as well as folded nuclei. The tumour cells were positive for CD30, CD3, EMA and ALK-1. Chemotherapy resulted in durable remission status. This case emphasizes the occurrence of anaplastic large cell lymphoma in the soft tissue and the favourable outcome of ALK-positive anaplastic large cell lymphoma.


Subject(s)
Activin Receptors, Type II/biosynthesis , Ki-1 Antigen/biosynthesis , Lymphoma, Large-Cell, Anaplastic/pathology , Muscle Neoplasms/pathology , Muscle, Skeletal/pathology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biomarkers, Tumor/analysis , Child , Combined Modality Therapy , Humans , Lymphoma, Large-Cell, Anaplastic/metabolism , Lymphoma, Large-Cell, Anaplastic/therapy , Male , Muscle Neoplasms/metabolism , Muscle Neoplasms/therapy
15.
Pathologica ; 101(1): 18-20, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19771768

ABSTRACT

According to the WHO-EORTC classification of cutaneous lymphomas, primary cutaneous marginal zone B-cell lymphoma are now well characterized. We report here a case of primary cutaneous marginal zone B-cell lymphoma in a 51 year-old man in which the diagnosis was made using both histology and immunopathology. The patient had no remarkable medical history, no history of either acute inflammation or insect bite, and presented with a 5 cm solitary asymptomatic erythematous firm, multinodular and infiltrated plaque on the back for 12 months. Histological examination and immunohistochemical study of a cutaneous biopsy provided a differential diagnosis between B cell lymphoma and lymphocytoma cutis. Full body work up revealed no signs of extracutaneous dissemination. The patient underwent surgical excision of the nodule. Histological examination showed a histological and immunophenotyping profile typical of primary cutaneous marginal zone B-cell lymphoma. The lesion was completely excised with clear margins and no recurrence occurred after a 12 month-follow-up period. Primary cutaneous marginal zone B-cell lymphoma are low-grade lymphomas that have an indolent course and a high tendency to recur. They should be differentiated from lymphocytoma cutis and from the other types of cutaneous B cell lymphomas that have a different course and prognosis.


Subject(s)
Lymphoma, B-Cell, Marginal Zone/diagnosis , Lymphoma, B-Cell, Marginal Zone/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Cell Differentiation , Diagnosis, Differential , Humans , Lymphoma, B-Cell, Marginal Zone/classification , Male , Middle Aged , Prognosis , Pseudolymphoma/pathology , Skin Neoplasms/classification , World Health Organization
16.
Am J Med Genet A ; 149A(3): 417-26, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19215041

ABSTRACT

Mowat-Wilson syndrome (MWS; OMIM #235730) is a genetic condition caused by heterozygous mutations or deletions of the ZEB2 gene, and characterized by typical face, moderate-to-severe mental retardation, epilepsy, Hirschsprung disease, and multiple congenital anomalies, including genital anomalies (particularly hypospadias in males), congenital heart defects, agenesis of the corpus callosum, and eye defects. Since the first delineation by Mowat et al. [Mowat et al. (1998); J Med Genet 35:617-623], approximately 179 patients with ZEB2 mutations, deletions or cytogenetic abnormalities have been reported primarily from Europe, Australia and the United States. Genetic defects include chromosome 2q21-q23 microdeletions (or different chromosome rearrangements) in few patients, and ZEB2 mutations in most. We report on clinical and genetic data from 19 Italian patients, diagnosed within the last 5 years, including six previously published, and compare them with patients already reported. The main purpose of this review is to underline a highly consistent phenotype and to highlight the phenotypic evolution occurring with age, particularly of the facial characteristics. The prevalence of MWS is likely to be underestimated. Knowledge of the phenotypic spectrum of MWS and of its changing phenotype with age can improve the detection rate of this condition.


Subject(s)
Abnormalities, Multiple/genetics , Aging/physiology , Craniofacial Abnormalities/genetics , Homeodomain Proteins/genetics , Phenotype , Repressor Proteins/genetics , Abnormalities, Multiple/diagnosis , Adolescent , Child , Child, Preschool , Chromosomes, Artificial, Bacterial , Dextrans/metabolism , Female , Fluorescent Dyes/metabolism , Heterozygote , Hirschsprung Disease/genetics , Humans , In Situ Hybridization, Fluorescence , Indoles/metabolism , Infant , Intellectual Disability/genetics , Italy , Male , Mutation , Nucleic Acid Hybridization , Oligonucleotide Array Sequence Analysis , Polymerase Chain Reaction , Syndrome , Young Adult , Zinc Finger E-box Binding Homeobox 2
18.
Rev Med Interne ; 30(4): 369-71, 2009 Apr.
Article in French | MEDLINE | ID: mdl-18722037

ABSTRACT

Squamous cell carcinoma arising in mature cystic teratoma of the ovary is an uncommon complication occurring usually in elderly woman. We present an unusual case of a post-menopausal woman with a synchronous mediastinum teratoma. While ovary tumor was symptomatic, mediastinal teratoma was an incidental finding. To the best of our knowledge, this association is the first to be reported in literature.


Subject(s)
Mediastinal Neoplasms/pathology , Ovarian Neoplasms/pathology , Teratoma/pathology , Aged , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Female , Humans , Mediastinal Neoplasms/diagnostic imaging , Mediastinal Neoplasms/surgery , Ovarian Neoplasms/diagnostic imaging , Ovarian Neoplasms/surgery , Teratoma/diagnostic imaging , Teratoma/surgery , Tomography, X-Ray Computed
19.
Pathologica ; 100(3): 181-4, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18841824

ABSTRACT

Desmoplastic spitz nevus (DSN) is an uncommon melanocytic lesion. The histologic features of this benign tumour may mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) or malignant (metastatic carcinoma and malignant melanoma) neoplasms. We report the case of a male with a DSN, and also review the clinical characteristics, histologic features and differential diagnosis of this extremely rare lesion. The lesion is identified as an asymptomatic reddish-brown dome-shaped papule on the forearm. Microscopic examination showed a symmetric lesion in the dermis. The neoplastic cells were large and epithelioid-shaped, and were either isolated as individual cells or arranged in small nests in a paucicellular hyalinized stroma. Nuclei were large and vesicular with small nucleoli and no mitoses. Diffuse expression of S100 and the absence of staining with antibodies to melan-A and HMB45 was observed. A diagnosis of DSN with free margins was made. The histologic presentation of this benign lesion mimics both benign and malignant neoplasms. The immunohistochemical profile (S100 positive, HMB-45 negative and cytokeratin negative) may be helpful to differentiate it from other lesions.


Subject(s)
Nevus, Epithelioid and Spindle Cell/pathology , Skin Neoplasms/pathology , Adult , Forearm , Humans , Male
20.
Pathologica ; 100(3): 199-201, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18841829

ABSTRACT

Malignant neoplasms arising in the epithelial component of breast fibroadenomas are rare. The most frequent types are lobular and ductal intra-epithelial carcinomas, with a minority of infiltrating carcinoma. We report a case of 36-year-old patient with invasive mucinous carcinoma (30 x 30 mm) arising in a complex breast fibroadenoma (130 x 60 x 30 mm). The patient underwent mastectomy with dissection of the axillary lymph nodes, which were free of tumour. The patient is alive without disease five years later. To the best of our knowledge, this is the first report of an invasive mucinous carcinoma arising within breast fibroadenoma. Our case provides information about the clinicopathologic characteristic of this unusual tumour.


Subject(s)
Adenocarcinoma, Mucinous/pathology , Breast Neoplasms/pathology , Fibroadenoma/pathology , Neoplasms, Multiple Primary/pathology , Adult , Female , Humans , Neoplasm Invasiveness
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