An Unusual Cause of Mediastinal Mass and Chylothorax.

Mediastinal masses are commonly encountered in clinical practice. The commonly encountered anterior mediastinal masses include those of thymic or thyroid origin, teratomas, and lymphoma. Establishing the diagnosis by histopathology is essential considering the wide range of differential diagnosis and to exclude malignancies. Here, we present an unusual case of large mediastinal mass with chylothorax in a young immunocompetent female.

Thymoma-associated immunodeficiency: a diagnostic challenge for the clinician.

Good's syndrome or thymoma-associated immunodeficiency is a rare clinical entity that is often presumed to be common variable immunodeficiency, due to lack of awareness and recognition of this syndrome. This syndrome more often goes unrecognized if a thymoma is not detected. An appropriate immunological work-up that aids timely diagnosis and adequate therapy with antimicrobials and intravenous immunoglobulins are mandatory to prevent the long-term complications and mortality associated with this syndrome. We present the clinical and immunological profile of a young man with Good's syndrome that was initially presumed to be common variable immunodeficiency.