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1.
Induction of brain D(--)-beta-hydroxybytrate dehydrogenase activity by fasting.
Smith, A L; Satterthwaite, H S; Sokoloff, L.
Science ; 163(3862): 79-81, 1969 Jan 03.
Article in English | MEDLINE | ID: mdl-4975341

ABSTRACT

D(m)-beta-hydroxybutyrate dehydrogenase activity is very low in normal adult rat brain; but during fasting it increases severalfold in parallel with the ketosis. The increase may represent part of a mechanism by which the brain adapts to changing patterns of substrate supply during starvation.


Subject(s)
Brain/enzymology , Enzyme Induction , Fasting , Hydroxybutyrate Dehydrogenase/biosynthesis , Acetoacetates/blood , Acidosis , Animals , Body Weight , Brain/cytology , Edetic Acid , Hydroxybutyrates/blood , Male , Mitochondria/enzymology , Organ Size , Phosphatidylcholines/metabolism , Rats
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